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501
Inhibition of cytochrome P450 epoxygenase promotes endothelium-to-mesenchymal transition and exacerbates doxorubicin-induced cardiovascular toxicity
منشور في 2024"…Thus, identifying the pathway involved in this toxicity may help minimize chemotherapy risk and improve cancer patients’ quality of life. Recent studies suggest that Endothelial-to-Mesenchymal transition (EndMT) and endothelial toxicity contribute to the pathogenesis of DOX-induced cardiovascular toxicity. …"
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502
The Prevalence and Genetic Spectrum of Familial Hypercholesterolemia in Qatar Based on Whole Genome Sequencing of 14,000 Subjects
منشور في 2022"…<p dir="ltr">Familial hypercholesterolemia (FH) is an inherited disease characterized by reduced efficiency of low-density lipoprotein-cholesterol (LDL-C) removal from the blood and, consequently, an increased risk of life-threatening early cardiovascular complications. …"
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503
Challenges and opportunities in biogas conversion to microbial protein: A pathway for sustainable resource recovery from organic waste
منشور في 2024"…Concurrently, urban expansion significantly increases organic waste, undermining both economic and environmental sustainability. …"
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504
Extent and Mitigation of Financial Toxicity of Immune Checkpoint Inhibitors for the Treatment of Advanced Hepatocellular Carcinoma
منشور في 2025"…We also aim to explore potential solutions to improve access to life-saving therapies such as ICIs. We conducted an exploratory targeted review of the current literature focusing on therapeutic advancements, their accessibility, and innovative strategies to overcome FT. …"
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505
Building thermal resilience framework (BTRF): A novel framework to address the challenge of extreme thermal events, arising from climate change
منشور في 2022"…Moreover, recently, the rate and the impacts of these extremes have increased, despite all the mitigation efforts, necessitating a resilience-based approach to address these challenges stemming from the accelerated global warming and the advent of climate change. …"
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506
Developing a Framework for Evaluating Accessibility Density and Coverage
منشور في 2015احصل على النص الكامل
doctoralThesis -
507
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508
The Integration of Agile Methodology in the Development of Software Project
منشور في 2024"…Agile proponents have produced a number of assertions regarding the advantages of agile approaches, such as increased group productivity and effectiveness, improved software reliability, and business effectiveness. …"
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509
Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis...
منشور في 2021"…</p><p><br></p><h3>Interpretation</h3><p dir="ltr">In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. …"
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510
Phase 1 and 2 Studies Demonstrate the Safety and Efficacy of Intraprostatic Injection of PRX302 for the Targeted Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prost...
منشور في 2011"…Phase 1 subjects received increasing concentrations of PRX302 at a fixed volume; phase 2 subjects received increasing volumes per deposit at a fixed concentration. …"
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article -
511
Prostate cancer burden in South Asia: A systematic analysis of global burden of disease data (1990–2021)
منشور في 2024"…<h3>Objectives</h3><p dir="ltr">The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability‐adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. …"
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512
Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis
منشور في 2024"…<h3>Background</h3><p dir="ltr">An increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. …"
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513
Ervilia castanea (Mollusca, Bivalvia) populations adversely affected at CO2 seeps in the North Atlantic
منشور في 2021"…This raises concerns about the effects of ocean acidification on the brood stock of this species and other bivalve molluscs with similar life history traits.…"
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article -
514
Public motives and willingness to participate in first-in-human clinical trials in Saudi Arabia: A new era in the making
منشور في 2019"…This study aims to investigate the Saudi public’s attitude toward FIH clinical trials, identify their willingness to take part in it, and their preferences for participating in these kinds of trials, given the fact that the Saudi FDA has never approved such studies in Saudi Arabia. …"
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article -
515
Chronic reduction of store operated Ca<sup>2+</sup> entry is viable therapeutically but is associated with cardiovascular complications
منشور في 2022"…<p>Loss of function mutations in store-operated Ca<sup>2+</sup> entry (SOCE) are associated with severe paediatric disorders in humans, including combined immunodeficiency, anaemia, thrombocytopenia, anhidrosis and muscle hypotonia. Given its central role in immune cell activation, SOCE has been a therapeutic target for autoimmune and inflammatory diseases. …"
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516
An Investigation into the factors influencing Arabic speaking students’ proficiency in the Arabic language in Dubai British School
منشور في 2022"…This is despite the fact that both groups of students are native Arabic speakers, and that both groups of students attend Arabic classes that use the same curriculum and textbooks. Given the high number of British as well as other non-Arabic schools in Dubai, this is a significant issue as many Arabic-speaking students are failing to achieve proficiency in their native language. …"
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517
Progress of liquid chromatography-mass spectrometry in measurement of vitamin D metabolites and analogues
منشور في 2011"…Liquid chromatography-mass spectrometry (LC-MS) has been increasingly utilized in these applications. In this work, our objective was to critically review the progress of LC-MS application in measuring vitamin D metabolites and analogues in biological fluids. …"
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article -
518
Enhanced oil recovery using hyperbranched polyglycerol polymer-coated silica nanoparticles
منشور في 2021"…Surface modification of Fe–Si-MNPs enhanced the oil adsorption, increased the adsorption capacity, and extended the service life resulting in a better cost and process feasibility.…"
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519
Nurse-Led System-wide Unit-based Hospital Acquired Pressure Injury (HAPI) Reduction Project
منشور في 2024"…HAPI is a significant patient safety issue in hospitalized patients and can lead to increased healthcare costs and a decreased quality of life for patients . …"
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520
Bridging Qatar's food demand and self-sufficiency: A system dynamics simulation of the energy–water–food nexus
منشور في 2024"…This heightened demand for energy and water translates into increased costs and escalates environmental impacts. …"