A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... حسب Abou-Ghazal, Mohamed

"…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of StarD13 on colorectal cancer proliferation, motility and invasion حسب Nasrallah, Anita

"…Colon cancer is a cancer of the epithelial cells lining the colon. It is mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Clinical correlates of white-matter abnormalities on head magnetic resonance imaging حسب Dimassi, Hani

"…Children with white-matter abnormalities and increased tone had a greater frequency of increased reflexes and tended to have more signal abnormalities than the other groups. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review حسب Aasir M. Suliman (14150217)

"…Nonetheless, tuberculosis (TB) reactivation during their use is increasingly recognized and reported. Herein, we present a 58-year-old lady with advanced non-small cell lung cancer (NSCLC) ALK-negative, EGFR wild, and PD-L1 immune histochemistry (IHC) strongly positive in 95% of tumor cells, on ongoing treatment with Pembrolizumab as a first-line monotherapy. …"

Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer حسب Said Dermime (79420)

"…To date, immune check-point inhibitors have been approved as first or second line therapy options in a broadening range of metastatic cancer and increasingly explored in the treatment of early stage tumors. …"

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer حسب Reem Saleh (3513056)

"…In this study, we investigated the molecular mechanisms by which the human TNBC cell line MDA-MB-231, expressing PD-L1, responds to atezolizumab, using RNA-Seq. …"

Prevalence and global trends of polypharmacy in patients with chronic kidney disease: A systematic review and meta-analysis حسب Lina Naseralallah (14146465)

"…In line with the therapeutic guidelines, managing CKD and its complications necessitates prescribing multiple medications, which predisposes patients to polypharmacy. …"

Need for Affect, Problematic Social Media Use and the Mediating Role of Fear of Missing Out in European and Arab Samples حسب Areej Babiker (17032314)

"…<h3>Purpose </h3><p dir="ltr">The growing awareness and concern about the excessive use of social media have led to an increasing number of studies investigating the underlying factors contributing to this behavior. …"

A Model of Telecommunication Sector Development and Economical Growth in GCC Countries: A Case Study of UAE حسب Amiri, Shaima Yousef

احصل على النص الكامل

The impact of cultural diversity on project management communication حسب HUSSEIN, ALAA BASSAM FUAD

"…The results of the study are in line with some previous research, who said that when examined in terms of age, gender, and ethnicity, having a diverse workforce has a positive impact on the organization's performance. …"
احصل على النص الكامل

Effects of selenium in comparison to exendin-4 on the expression of GLP-1R, IRS-1 and preproinsulin in the pancreas of diabetic rats حسب Rizk, Sandra

"…It binds and activates GLP-1R with greater potency than GLP-1 and is used in the treatment of diabetes mellitus. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Epidemiological and clinical characteristics of fall-related injuries: a retrospective study حسب Ahammed Mekkodathil (4578838)

"…Although the rate of fall-related injuries decreased over the years, the average number of patients per year remained high accounting for 32% of the hospitalized patients with moderate to severe injuries. …"

Trends in criminal convictions in Japan for vehicle collisions where one driver suffers from an epileptic seizure حسب Mineko Baba (19774386)

"…To reduce collisions to an even greater degree, this type of collision should be prevented. …"

The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports حسب Marta, Bassi

"…Our results substantiated that MDPHP and MDPV similarly affect sensorimotor and behavioural responses in mice, importantly increased locomotion and induced aggressive behaviour, and, at higher dosage, increased heart rate and blood pressure. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? حسب Abu Saleh Md Moin (6189512)

"…Vitamin D deficiency was associated with decreased CD80 and IFN-γ in PCOS and IL-12 in both groups (p<0.05). …"

Effects of COVID-19 on Autism Spectrum Disorder in Qatar حسب Fouad A. Alshaban (17281108)

"…Parents also reported decreased access to family and social support networks, as well as decreased quality of clinical and community support. …"

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death حسب Tohme, Sara

"…This is followed by an increase in lipid peroxidation which peaks at later timepoints and varies between different cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Clinical characteristics and outcome of children with acute cryptorchid testicular torsion: A single-center, retrospective case series study حسب Zlatan Zvizdic (9212371)

"…Preoperative color Doppler ultrasonography revealed absent or decreased testicular blood flow in the affected testes in 7/8 of patients. …"

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome حسب Abu Saleh Md Moin (6189512)

"…These protein panels target biological processes involved in vessel damage, platelet degranulation, the coagulation cascade and the acute phase response [1], with greater protein changes dependent on the COVID-19 severity. …"

A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country حسب Nancy Zaghloul (14147865)

"…The trend among SGLT2is suggests greater preference for empagliflozin over dapagliflozin.…"