Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans حسب Kirti S. Prabhu (4246144)

"…In addition to cell lines, we assessed the impact of BTZ in an in vivo setting using Caenorhabditis elegans (C. elegans). …"

An imageable retinoid acid derivative to detect human cancer xenografts and study therapeutic dosing to reduce its toxicity حسب Wang, Wei

"…Therapeutic agents labeled with reporters will interrogate tumor–drug interactions and permit analysis of biodistribution, pharmacokinetics and pharmacodynamics in real time. At the same time, we can apply the biologically effective dose for therapy, instead of the traditional maximum tolerated dose, to reduce systemic toxicity…"
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Influence of shelf-life duration on mechanical, thermal and shape recovery motion derivatives of shape memory polyurethane حسب Vasavi, Boggarapu

"…The results indicated that tensile and flexural strength decreased by 35.16 % and 29.3 % respectively, from S1 to S10. …"
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Urtica dioica extract and its impact on blood lipids, glycemia & inflammation in the rat model. (c2005) حسب Baroudy, Karmen George

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The role of objectively recorded smartphone usage and personality traits in sleep quality حسب Aftab Alam (5158601)

"…The usage data of smartphone apps were processed to calculate smartphone usage amounts and sleep variables, including sleep duration, sleep distraction, sleeping time, and wake-up time. The data were analyzed using the correlation coefficient and regression analyses.…"

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice حسب Julie Decock (44558)

"…Using quantitative real-time RT-PCR, we tracked the expression of the entire Mmp and Timp gene families, observing a significant decrease in Mmp3 expression in Mmp8-null tumors compared to wild-type and heterozygotes throughout the time course of the model, which was confirmed at the protein level. …"

Bridging the gap between KG2 and grade one activity kit. (c2010) حسب Hammoud, Maya

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Removal of nitrate from JUST wastewater effluent: a case study حسب Al-Asheh, Sameer

"…From kinetic studies, equilibrium time was as short as 10 min. It was observed that pH plays an important role in the nitrate adsorption process. …"
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Thermodynamic analysis of a novel integrated geothermal based power generation-quadruple effect absorption cooling-hydrogen liquefaction system حسب Ratlamwala, Tahir Abdul Hussain

"…Moreover, increasing the temperature of geothermal source degrades the performance of the quadruple effect absorption system (QEAS), but at the same time it affects the liquefaction production rate of hydrogen gas in a positive way. …"
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Investigating the Therapeutic Effects of Small Molecule Imipridones In Pediatric Neuroblastoma حسب El Soussi, Sarra

"…MYCN expression was significantly abrogated in the IMR-32 cell line with either drug treatment. The protein expression of Sox-2, Oct-4, FABP5 and HMGA1 was significantly reduced whereas cleaved PARP1 and caspase-3 and p-H2AX was increased 48 h after drug treatment in the MYCN-amplified IMR-32 cell line. …"
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Clinical characteristics and outcome of children with acute cryptorchid testicular torsion: A single-center, retrospective case series study حسب Zlatan Zvizdic (9212371)

"…</p><p><br></p><h3>Conclusions</h3><p dir="ltr">Greater awareness among caregivers and primary care physicians about acute cryptorchid TT is required to improve their timely diagnosis and treatment. …"

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma حسب Peter Kubatka (11008854)

"…However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. …"

Do interleukin-6 and macrophage-migration inhibitory factor play a role during sex-associated susceptibility in murine cysticercosis? حسب Kabbani, Ahmad

"…However, in wild-type strains, females have twice as many parasites as males. At the same time, there is a decrease of 80% in testosterone and dihydrotestosterone serum levels, and a 100-fold increase in the levels of estradiol in infected male mice. …"
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Wave-packet dynamics in monolayer graphene with periodic scattering potentials حسب M.M. Suleimanov (22921019)

"…<p dir="ltr">We use the Dirac <u>continuum model</u> to study the propagation of electronic wave packets in monolayer graphene in the presence of periodically arranged circular potential steps. The time propagation of the wave packets is calculated using the split-operator method for different sizes, heights, and separations of the barriers. …"

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy حسب Nassiba Taib (14557385)

"…</p><h2>Methods</h2><p dir="ltr">We compared the effect of DAC in primary 1076 Col and metastatic 1872 Col cell lines isolated and generated from patients’ tumor tissues. …"

Dissecting the signaling pathways regulating the vascular endothelial growth factor (VEGF) in brain tumor cells. (c2017) حسب Nicolas, Samer Michel

"…However, when both RhoA and RhoC were knocked down, VEGF expression decreased after EGF stimulation. Moreover, when the astrocytoma cells were subjected to hypoxia at different times, we detected a significant increase in pERK. …"
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Grid electricity demand reduction through applying passive and active strategies for a house in Baghdad, Iraq حسب Al-Badri, Nadia Rashid

"…The production time of the PV should be observed to find out if it corresponds with the demand time or needs to be stored either in a battery or connected to the main grid. …"
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Evidence-based safety education and training for traffic injury prevention حسب Abbas Motevalian (338825)

"…Stronger GDL programs achieve greater fatality reduction. A systematic review on the effects of post-license driver education, provides no evidence of its effects on preventing road traffic crashes or injuries. …"

Utilization of the internet for physical activity and diet information and its influence on pregnant women’s lifestyle habits in Qatar حسب Ayman Al-Dahshan (8962568)

"…</p><h3>Conclusion</h3><p dir="ltr">Many pregnant women use the internet to access information about PA and diet, and greater use is associated with more positive lifestyle changes. …"

Thymoquinone from Nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro حسب Khalife, Rana

"…In conclusion, thymoquinone increased the effectiveness of the chemotherapeutic reagent topotecan by inhibiting proliferation and lowering toxicity through p53- and Bax/Bcl2-independent mechanisms.…"
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