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641
The Safety of Novel Therapies in Chronic Lymphocytic Leukemia in the Era of Intermittent Fasting: A Pharmacology-Based Review
منشور في 2024"…Unfortunately, it is unclear whether the associated risks of tumor lysis syndrome (TLS) and gastrointestinal bleeding (GIB) are increased in IF practitioners receiving NAs. This review explored the literature available on the permissibility of IF in CLL patients undergoing treatment with first-line NAs (FLNAs). …"
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642
<i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
منشور في 2022"…In the present study, we investigated the effects of a methanol crude extract called “T1” of <i>H. pulvialis</i> on cell growth and migration/invasion of the BC cell line MDA-MB-231 in comparison to the fibroblast control cells. …"
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643
National Culture and Leadership in the United Arab Emirates (UAE)
منشور في 2012"…And finally, the study recommends that organisations should hold all the senior executives and line managers accountable for the development of individual managers by owning and executing succession plans.…"
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644
The Effectiveness of Mobile Phone Messaging–Based Interventions to Promote Physical Activity in Type 2 Diabetes Mellitus: Systematic Review and Meta-analysis
منشور في 2022"…<h3>Background</h3><p dir="ltr">The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. Physical activity (PA) is an important aspect of self-care and first line management for T2DM. …"
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645
Reply to Comments by Kakkar and Dahiya
منشور في 2014"…TO THE EDITOR: Chahine, Karaoui, and Mansour1 reviewed the efficacy and safety of bedaquiline in the treatment of adults with pulmonary multidrug-resistant tuberculosis (MDR-TB) and generally agree with the comments made by Kakkar and Dahiya.2 Bedaquiline was approved by the Food and Drug Administration based largely on results from phase 2 studies using sputum conversion as a surrogate marker for efficacy rather than long-term mortality data.2 Bedaquiline was shown to be associated with an unfavorable side effect profile, including an unexplained increased risk of mortality, QT prolongation, and elevated liver function tests.2 However, it is important to acknowledge that bedaquiline is the first novel drug to be approved for the treatment of TB in more than 4 decades and the communities devastated by MDR-TB are in desperate need for more options to manage their patients. …"
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646
In Vitro and In Vivo Effects of Lebanese Cannabis Oil Against Acute Myeloid Leukemia (AML)
منشور في 2023"…WEHI-3 cells were treated with increasing concentrations of COE to determine the IC50 after 24, 48 and 72-hours post treatment. …"
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masterThesis -
647
Towards electric digital twin grid: Technology and framework review
منشور في 2023"…Thus, the power grid transmission loss and location of the overheated line and power connection missing can be detected in addition decision-making and self-healing can possible. …"
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648
Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism
منشور في 2023"…<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. …"
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649
Simulating blood vessel scaffolds
منشور في 2015"…According to their simulations, the amount of shear stress is highest at the endoluminal strut surface, where the stent comes into contact with the inner lining of the vessels, but very low at the areas where blood flows in and out of the device. …"
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650
Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review
منشور في 2022"…Nonetheless, tuberculosis (TB) reactivation during their use is increasingly recognized and reported. Herein, we present a 58-year-old lady with advanced non-small cell lung cancer (NSCLC) ALK-negative, EGFR wild, and PD-L1 immune histochemistry (IHC) strongly positive in 95% of tumor cells, on ongoing treatment with Pembrolizumab as a first-line monotherapy. …"
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651
Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
منشور في 2021"…To date, immune check-point inhibitors have been approved as first or second line therapy options in a broadening range of metastatic cancer and increasingly explored in the treatment of early stage tumors. …"
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652
PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer
منشور في 2019"…In this study, we investigated the molecular mechanisms by which the human TNBC cell line MDA-MB-231, expressing PD-L1, responds to atezolizumab, using RNA-Seq. …"
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653
Prevalence and global trends of polypharmacy in patients with chronic kidney disease: A systematic review and meta-analysis
منشور في 2023"…<h3>Background and objectives</h3><p dir="ltr"> Polypharmacy and chronic kidney disease (CKD) are becoming increasingly common due to an ageing population and the rise of multimorbidity. …"
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654
A possible culprit for refractory angina
منشور في 2015"…</p><p>This may implicate lipoprotein(a) as having a causal role in refractory angina, but the findings still need to be confirmed by testing a control group of patients who have coronary heart disease but not refractory angina.</p><p>An increased lipoprotein(a) level is known to be highly heritable, and is believed to promote hardening of the arteries by trapping cholesterol in the inner linings of blood vessels, promoting clot formation, recruiting inflammatory cells, or binding pro-inflammatory phospholipids.…"
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655
Need for Affect, Problematic Social Media Use and the Mediating Role of Fear of Missing Out in European and Arab Samples
منشور في 2023"…<h3>Purpose </h3><p dir="ltr">The growing awareness and concern about the excessive use of social media have led to an increasing number of studies investigating the underlying factors contributing to this behavior. …"
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656
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657
The impact of cultural diversity on project management communication
منشور في 2022"…The results of the study are in line with some previous research, who said that when examined in terms of age, gender, and ethnicity, having a diverse workforce has a positive impact on the organization's performance. …"
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658
Trace element composition of size-fractionated suspended particulate matter samples from the Qatari Exclusive Economic Zone of the Arabian Gulf: the role of atmospheric dust
منشور في 2020"…For several other elements (Cd, Cu, Mo, Zn, and Ca) the excess concentrations present after lithogenic correction are most likely of biogenic/anthropogenic origin. The excess concentrations, relative to average dust, for most elements (except Cd) decreased with distance from the shore, which may be due to differences in biology, currents, proximity to the coast, or interannual processes.…"
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659
Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study
منشور في 2020"…Females were 1.18 times more likely to have polypharmacy compared to males (95% CI: 1.03–1.34). …"
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660
Correction: Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study
منشور في 2020"…Females were 1.18 times more likely to have polypharmacy compared to males (95% CI: 1.03–1.34). …"