Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro by Najem, Sonia A.

“…Objective: In this study, we evaluated the effect of Suberoylanilide Hydroxamic Acid (SAHA), a panhistone deacetylase inhibitor, and Decitabine (DAC), a DNA methyltransferase inhibitor, either alone or in combination, on Caco-2 human colon cancer cell line in vitro. Results: Our results showed that SAHA and DAC, separately, significantly decreased cell proliferation, induced apoptosis and cell cycle arrest of Caco-2 cell line. …”
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Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050 by Yingzhao, Jin

“…The disease burden of gout, LBP, and OA attributable to high BMI and gout attributable to kidney dysfunction increased, while the contribution of smoking to LBP and RA and occupational ergonomic factors to LBP decreased. Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs but decreased for LBP and RA. …”
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Impact of abiraterone on patient-related outcomes in metastatic castration-resistant prostate cancer by El-Amm, Joelle

“…Abiraterone acetate has established a major role in the treatment paradigm of metastatic castration-resistant prostate cancer ever since pivotal trials, COU-AA-301 and COU-AA-302, have shown benefit in both the second-line and first-line (post- and pre-chemotherapy) setting, respectively, with improvement in overall survival as well as secondary end points such as prostate-specific antigen (PSA) and radiographic response rates, time to PSA progression, and progression-free survival. …”
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Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 by Natalia V, Bhattacharjee

“…Additionally, the distribution of livebirths across the globe is shifting, with a greater proportion occurring in the lowest-income countries. …”
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Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report by Maysaloun Merhi (4246147)

“…His NY-ESO-1 antibody was found to be lower after the third (****p < 0.0001) and the fifth (****p < 0.0001) cycles of treatment compared to base line, and this was in line with the stability of the disease. …”

Implementation of trust region methods in optimization. (c1998) by Hajj, Mohammed Omar

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The changing landscape in the treatment of metastatic castration-resistant prostate cancer by El Amm, Joelle

“…The past few years have brought increasing advances in the therapeutic management of metastatic castration-resistant prostate cancer with the approval of several agents, including vaccine therapy with sipuleucel-T, second-line chemotherapy with cabazitaxel, the bone-targeted pharmaceutical denosumab, and the novel antiandrogen therapy abiraterone acetate. …”
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Emerging therapies in multiple myeloma by El-Amm, Joelle

“…However, despite the increased effectiveness of the first-line agents, the majority of patients will eventually relapse and become drug resistant. …”
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Ultrasonically Triggered Release of Folic Acid-Conjugated Liposomes for Breast Cancer Therapy Within Microfluidic Devices by AlHazaimeh, Taima Khair Alla

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Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors by Naila Rabbani (291722)

“…In the National Cancer Institute human tumor cell line screen, BBGD was most active against the glioblastoma SNB-19 cell line. …”

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer by Ghaneya Al-Khadairi (14153274)

“…Gene ontology analyses revealed enrichment of genes that are dysregulated in ovarian and esophageal cancer and are involved in transcription and apoptosis. In line with this, interrogation of TCGA and GTEx data demonstrated an increased PRAME expression in ovarian and esophageal tumor tissues in addition to breast tumors where it is associated with worse survival. …”

Modeling and Performance Analysis of mmWave and WiFi-Based Vehicle Communications by Mohamed Rjab (21393908)

“…This study explores a comparative analysis of mmWave and WiFi transmission technologies, with a specific focus on line-of-sight (LoS) and non-line-of-sight (NLoS) scenarios in both 2D and 3D modeling environments. …”

3D FEM Model on the Parameters’ Influence of EPB-TBM on Settlements of Single and Twin Metro Tunnels During Construction by Masoud Forsat (14158980)

“…<p>The present research exposes the investigation on three-dimensional modeling of the single and twin metro tunnels for the case of the Tehran metro line. At first, simulation implemented on the comparison of the ground movements in the single and twin tunnels. …”

Lyapunov-Function-Based Controller for Single-Phase NPC Quasi-Z-Source Inverter with 2<em>ω</em> Frequency Ripple Suppression by Sertac Bayhan (16388511)

“…Furthermore, the modified simple boost control technique is proposed to eliminate the double-line frequency ripples in the quasi-impedance source inductor currents and minimize the double-line frequency ripples in the quasi-impedance source capacitor voltages. …”

The history and development of newspaper electronic pagination systems in the United States, 1975-1987 by Beyrouti, Nouri

“…This was perhaps, due to the unevenness with which the total pagination process has developed, and the continuing problems involved in merging line-art and graphics with text. Increased computer storage space and other advances may solve this problem soon, and satellite transmission of graphic art for national advertisements, to specific newspapers is a new development being planned for the near future.…”
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Marketing communications by Beyrouti, Nouri

“…Sponsorship has become increasingly popular - within companies that operate in consumer markets. …”
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The burden of prostate cancer in North Africa and Middle East, 1990–2019: Findings from the global burden of disease study by Mohsen Abbasi-Kangevari (9714440)

“…This study presents estimates of PCa prevalence, incidence, death, years-of-life-lost (YLLs), years-lived-with-disability (YLDs), disability-adjusted-life-years (DALYs), and the burden attributable to smoking during 1990-2019 in North Africa and Middle East using data of Global Burden of Diseases (GBD) Study 2019.…”

Analysing the State of Inclusive Education in China: Challenges and Perspectives by Zainab Merchant

“…Key recommendations include ongoing monitoring, clear policy directives, increased family involvement, and enhanced teacher training. …”
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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Gaussian accelerated molecular dynamics (GaMD) simulations of the predicted alpha-helical synthetic Mpro cleavage sequences revealed a dynamic nature of the cleavage sequences, which is critical for their efficient cleavage, and a relatively short end-to-end distances, which is required for high BRET. Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …”
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Students at risk of academic failure: Could differentiated instruction be a catalyst for school reform? by WILSON-GULSTON, DANIELLE

“…One of the main motivations and intent for undertaking this line of research is due to the sustained concern around the continuously increasing rates of attrition among students in the Caribbean. …”
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