A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. …”
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D 2IA: User-defined interval analytics on distributed streams by Awad, Ahmed

“…In most of the cases, data items and events are considered instantaneous, i.e., they are single time points in a discrete temporal domain. Nevertheless, a point-based time semantics does not satisfy the requirements of a number of use-cases. …”
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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Tumor protease-activated fusion toxins by Abi-Habib, Ralph J.

“…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”

Inositol 1,4,5-Trisphosphate Receptors in Hypertension by Ali H. Eid (5461829)

“…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca²⁺ signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

“…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”

Clinical characteristics and outcome of children with acute cryptorchid testicular torsion: A single-center, retrospective case series study by Zlatan Zvizdic (9212371)

“…</p><p><br></p><h3>Conclusions</h3><p dir="ltr">Greater awareness among caregivers and primary care physicians about acute cryptorchid TT is required to improve their timely diagnosis and treatment. …”

Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon by Hage-Sleiman, Rouba

“…Increasing the dose to 500 mg/kg body weight caused a significant decrease in stool water content. No adverse effect on liver enzymes was observed. …”
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Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition by Bouclaous, Carmel

“…All groups showed a decrease in relative intestinal absorption with time. …”
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Modeling circadian clock–cell cycle interaction effects on cell population growth rates by El Khatib, N.

“…Particularly, we show that Cry 1, Cry 2 mutations decrease the growth rate of cells, Per 2 mutation enhances it and Bmal 1 knockout increases it for autonomous periods of the cell cycle less than 21 h and decreases it elsewhere. …”
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Successful Use of Intravenous B-blocker Therapy in Cardiogenic Shock Supported With Venoarterial Extracorporeal Membrane Oxygenation: A Case Series by Alaa Rahhal (14150403)

“…<p dir="ltr">Tachycardia in cardiogenic shock (CS) might reduce the cardiac output (CO) by decreasing the ventricular filling time. Nevertheless, heart rate (HR) control with agents that possess negative inotropy might decrease the CO. …”

A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems by Raka Jovanovic (17947838)

“…The problem is modelled using a mixed integer program (MIP) in which the charging time of an EB is pertinent to the battery’s state-of-charge level. …”

Fabrication of titanium dioxide nanomaterial for implantable highly flexible composite bioelectrode for biosensing applications by Omnia Mohamed (15862753)

“…The fabricated electrodes appeared to have a smooth surface, as seen in the scanning electron microscope micrographs, compared with electrodes in the literature. Long-time stability tests revealed an overall decrease in impedance and an increase in the charge capacity up to 475% of the initial value within three weeks.…”

Stress granules counteract senescence by sequestration of PAI‐1 by Amr Omer (18629374)

“…However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. …”

Formation of Trihalomethanes during Seawater Chlorination by Ahmed Abdel-Wahab (1748986)

“…Rapid decrease of UV absorbance at 254 nm was also observed during seawater chlorination which is indicative of natural organic matter degradation into small organic molecules including THMs and other by-products. …”

Combining Saliency with Prediction for Endoscopic Diagnosis by Rezk, Mahmoud

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Ultrasound‑triggered herceptin liposomes for breast cancer therapy by Elamir, Amal

“…Exposing the liposomes to low-frequency ultrasound (LFUS) triggered drug release which increased with the increase in power density. Trastuzumab conjugation resulted in enhancing the sensitivity of the liposomes to LFUS. …”
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Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment by Christos Fountoukis (4722963)

“…The model’s forecast accuracy was assessed against measurement data from five ground air quality monitoring stations in the greater metropolitan area of Doha over a one-month period. …”