Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal by Zehra Irshad (18614869)

“…Proteins susceptible to MG modification were enriched in protein folding, protein synthesis, serine/threonine kinase signalling, glycolysis and gluconeogenesis. MG was increased in high glucose by increased flux of MG formation linked to increased glucose metabolism mediated by proteolytic stabilisation and increase of hexokinase-2 (HK-2); later potentiated by proteolytic down regulation of glyoxalase 1 (Glo1) - the major enzyme of MG metabolism. …”

The Potential of Lettuce Seed Assay for Sustainable Applied Toxicity Testing by Ammar M. S. Abdalla (23752962)

“…<p dir="ltr">This study was conducted to establish an approach for environmental toxicity assessment by using Effect-Directed Analysis (EDA) to increase the chances of toxicant identification through links between toxicity testing and chemical analysis. …”

The Association Between Estrogen‐Containing Oral Contraceptive Pills and Hypothyroidism by Lama Alkahlout (22392196)

“…These findings highlight the need for further research to explore the mechanisms linking OCP use to thyroid dysfunction and to investigate other potential risk factors.…”

Mitigating the impact of cultural diversity on the innovation process in the private sector in Dubai by HAJI, HASSAN

“…It is true that the aim of any business is to make profit, with decreased profit in the sector many entrepreneurs have discovered other investment schemes which has resulted to more demand of the workforce. …”
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Integration of Smart Sensors in Buildings to achieve Energy Efficiency in Hot and Humid Climate by JABR, BILAL SUDQI SAEED

“…It is also estimated that this utilization would grow to above 50% by 2030 because of the fast and consistent growth in economic activity and increase in population around the world. People tend to spend the greater part of their time in indoor spaces e.g., commercial and residential buildings. …”
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The Islamist groups in Tripoli. (c2008) by Abbas, Nivine H.

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RFX3 is essential for the generation of functional human pancreatic islets from stem cells by Bushra Memon (4792767)

“…</p><h3>Data availability</h3><p dir="ltr">The RNA-seq datasets have been submitted to the Zenodo repository and can be accessed via the following links: DOI https://doi.org/10.5281/zenodo.13647651 (PPs); and DOI https://doi.org/10.5281/zenodo.13762055 (SC-islets).…”

Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 by Natalia V, Bhattacharjee

“…Additionally, the distribution of livebirths across the globe is shifting, with a greater proportion occurring in the lowest-income countries. …”
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An empirical investigation of the relation between emotional intelligence and job satisfaction in the Lebanese service industry by Dagher, Grace K.

“…The escalating popularity of the Emotional Intelligence concept along with the increase in life/work outcomes that it is supposed to affect has lead researchers to scientifically investigate its relation to several of these outcomes. …”
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Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021 by Austin, Carter

“…Additionally, we introduced two new metrics to our reporting: prevalence of unsuppressed viraemia (PUV), which represents the proportion of the population without a suppressed level of HIV (viral load <1000 copies per mL), and period lifetime probability of HIV acquisition, which quantifies the hypothetical probability of acquiring HIV for a synthetic cohort, a simulated population that is aged from birth to death through the set of age-specific incidence rates of a given time period. FindingsGlobal new HIV infections decreased by 21·9% (95% UI 13·1–28·8) between 2010 and 2021, from 2·11 million (2·02–2·25) in 2010 to 1·65 million (1·48–1·82) in 2021. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Marissa B Reitsma (8674341)

“…We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. …”

Global, regional, and national burden of household air pollution, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Fiona B, Bennitt

“…InterpretationAlthough the burden attributable to HAP has decreased considerably, HAP remains a substantial risk factor, especially in sub-Saharan Africa and south Asia. …”
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Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal... by Haidong, Wang

“…InterpretationOver the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. …”
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Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Stud... by Robert C Reiner (5147636)

“…Findings The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1–65·8), 17·4% (7·7–28·4), and 59·5% (34·2–86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. …”

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal... by Haidong Wang (47381)

“…Interpretation Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. …”

Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 by Hmwe Hmwe Kyu (8674014)

“…During the same period, LRI episodes and deaths in children younger than 15 years were estimated to have decreased, and the greatest decline was observed for LRI deaths in males younger than 5 years (–70·7% [–77·2 to –61·8]). …”

Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burd... by Katherine R Paulson (8674293)

“…</p><p><br></p><h3>Findings</h3><p dir="ltr">Global U5MR decreased from 71·2 deaths per 1000 livebirths (95% uncertainty interval [UI] 68·3–74·0) in 2000 to 37·1 (33·2–41·7) in 2019 while global NMR correspondingly declined more slowly from 28·0 deaths per 1000 live births (26·8–29·5) in 2000 to 17·9 (16·3–19·8) in 2019. …”

Performance analysis of FSO cooperative communications with rf inter-connected relays in the absence and presence of channel state information. (c2018) by Hamad, Mustapha Ismail

“…Moreover, RF links are used as backup for the FSO links of practical FSO systems which exist in the market today. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…Decreased whole body exposure to MG-derived AGEs may be linked to increased weight specific physical activity of HSA-mUCP1 mice. …”
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Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide by Pruitt, John D.

“…The polymerizations resulted in an interpenetrating network of poly(NNDEA) and P-105 that stabilized the micelles at concentrations below the critical micellar concentration of free P-105. The NNDEA was cross-linked with N,N′-bis(acryoyl)cystamine (BAC), and the degree of micellar stability was determined using dynamic light scattering and the fluorescent probe diphenylhexatriene (DPH).The increased micellar stability was not permanent and disappeared over a time period of days to weeks.…”
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