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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017)
Published 2017“…In this study, we examined the mechanisms of arginine auxotrophy in PC cell lines. Sensitivity to arginine depletion using HuArgI (Co)-PEG5000 was evident in all of the tested PC cell lines with IC50 values in the pM range at 72 hours following treatment. …”
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"Development of Authentic Annual and Seasonal Lightning Thunderstorms Day Maps for Saudi Arabia"
Published 2006“…Annual thunderstorms are most frequent over the southwestern parts of the country, and generally decrease towards the west and east. Due to its low latitude and less temporal change, the west coast of the Red Sea recorded the lowest Td/yr. …”
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"Thunderstorm distribution and frequency in Saudi Arabia"
Published 2005“…Annual thunderstorms are most frequent over the southwestern parts of the country, and generally decrease towards the west and east. Due to its low latitude and less temporal change, the west coast of the Red Sea recorded the lowest Td/yr. …”
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Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells
Published 2021“…Western blot analysis showed significant decrease in stem cell markers SOX-2 and Oct-4, and tumorigenic protein HMGA1, whereas it showed significant increase in apoptotic markers cleaved PARP and cleaved caspase-3. …”
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Effect of Construction Void Defects on Flexural and Axial Load Capacity of Reinforced Concrete Members
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doctoralThesis -
69
Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways
Published 2017“…Western blot analysis revealed a significant decrease in p-Erk, p-Akt, pro-caspase-3 and Bcl-2 and an increase in p53, p21, Bax and PARP proteins. …”
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Exercise-induced Citrate Enhances Associative Memory Formation by Modulating Histone Acetylation in a Sex-dependent manner
Published 2023“…Exercise stimulates the release of metabolites from the liver and muscles known as "exercise factors" into the circulation. …”
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masterThesis -
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Cytotoxicity of Arginine Deprivation to AML Cells is Mediated by Autophagy
Published 2020“…[HuArgI(Co)-PEG5000]-induced arginine deprivation led to significant and sustained activation of autophagy starting at 24 hours and lasting up to 120 hours following arginine deprivation in all cell lines. Inhibition of autophagy, using chloroquine, led to a significant decrease in cell cytotoxicity evident at 48 hours and up to 120 hours. …”
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masterThesis -
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer
Published 2020“…In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. Our results show a decrease in the migratory rate of the cells and their rate in wound closure. …”
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masterThesis -
73
The Antioxidant and Pro-apoptotic effects of Sternbergia clusiana Bulb Ethanolic Extract on Breast Cancer Cells in vitro
Published 2021“…MDA-MB-231 cells treated with SbBEE exhibited morphological and biochemical hallmarks of apoptosis that were detected through DNA fragmentation, the hyper-expression of phosphatidylserine on the outer leaflet of cells membrane and the upregulation of proteins able to mediate cell death through apoptosis (c-PARP, Bax/ Bcl2). The prominent decrease in ROS levels upon treatment confirmed the antioxidant property of the extract being investigated, highlighting the promising effect of SbBEE in breast cancer treatment.…”
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masterThesis -
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Parallel multi-voltage power minimization in VLSI circuits. (c2013)
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masterThesis -
75
ROS-Mediated Autophagic Death in Glioblastoma Cells Upon Treatment by Human Recombinant Arginase I (Co)- PEG5000 [HuArgI (Co)-PEG5000]
Published 2021“…Addition of N-acetyl-cysteine (NAC); being a reactive oxygen species (ROS) scavenger, led to a significant decrease in the cytotoxicity of arginine deprivation to U251 and A172 cells, indicating that ROS generation reversed the cytotoxicity of arginine deprivation to GBM cells. …”
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Metformin inhibits 2D and 3D motility in astrocytoma cancer cells. (c2014)
Published 2016“…Metformin is highly used in polycystic ovary syndrome (PCOS), premature puberty, and non-alcoholic fatty liver disease (NAFLD). A brain tumor is an intracranial solid neoplasm which is a tumor within the brain or the central spinal canal. …”
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77
Artificial neural network algorithms. (c1999)
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Visitors off the trail: Impacts on the dominant plant, bryophyte and lichen species in alpine heath vegetation in sub-arctic Sweden
Published 2021“…With a greater decrease in taller forbs and shrubs than in graminoids and prostrate plants, a greater decrease in lichen than in bryophyte species, and a change in vegetation composition. …”
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Portal vein embolization
Published 2001“…Conclusion: This treatment does not increase the risks associated with major liver resection. …”
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