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Chemotherapy prior to Hepatic Resection for Colorectal Liver Metastases: Helpful until Harmful?
منشور في 2009"…Steatohepatitis is associated with irinotecan therapy and an increased risk for liver failure and death after hepatic resection. …"
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23
Systemic Chemotherapy and Two-Stage Hepatectomy for Extensive Bilateral Colorectal Liver Metastases
منشور في 2007"…Background Two-stage hepatectomy has been proposed for patients with bilateral colorectal liver metastases (CLM). The aim of this study was to compare the outcome of patients with CLM treated with preoperative chemotherapy followed by one- or two-stage hepatectomy. …"
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24
Effect of Anthrax Lethal Toxin on Activation of MAPK Pathway and Autophagy in AML Cell Lines
منشور في 2021"…This study aims to explain the difference in susceptibility of different AML cell lines. Flow cytometry analysis of downstream effectors of MEK showed decrease in phosphorylation of ERK and its downstream effectors only at early time points in sensitive cell lines. …"
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masterThesis -
25
Novel biomarkers for potential risk stratification of drug induced liver injury (DILI)
منشور في 2019"…<h3>Background:</h3><p dir="ltr">Drug induced liver injury (DILI) is an increasing cause of acute liver injury especially with increasing need for pharmacotherapy of widening comorbidities amongst our ever-aging population. …"
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Noncoding RNAs in Nonalcoholic Fatty Liver Disease: Potential Diagnosis and Prognosis Biomarkers
منشور في 2020"…<p>Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide in part due to the concomitant obesity pandemic and insulin resistance (IR). …"
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Deep learning-based modeling of land use/land cover changes impact on land surface temperature in Greater Amman Municipality, Jordan (1980–2030)
منشور في 2024"…This study aimed to model past, present, and future LULCC on Land Surface Temperatures in the Greater Amman Municipality (GAM) in Jordan between 1980 and 2030. …"
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29
Chemotherapy Regimen Predicts Steatohepatitis and an Increase in 90-Day Mortality After Surgery for Hepatic Colorectal Metastases
منشور في 2006"…The effect of chemotherapy and liver injury on perioperative outcome was analyzed. …"
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30
Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases
منشور في 2010"…For example, a few years ago an extrahepatic metastasis effectively eliminated surgical resection, but a combination of chemotherapeutic options and surgical techniques has expanded the indications for resection and increased the population of patients who may benefit.1,2 Neoadjuvant chemotherapy has increased the resectability rate by 11% to 37%.1 Unfortunately, greater than 80% of patients undergoing hepatic resection will have recurrences, mostly within the first 2 years.2 Nonetheless, the only hope for cure is resection, and prior surgical dogma based on the number of lesions, size of the tumor-free resection margin, and presence of resectable extrahepatic disease must be questioned.3- 5 The current standard approach to surgical planning is contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) for specific tumor characteristics or contraindications to CT.6 Several series showed that focal extrahepatic disease, an isolated pulmonary lesion, can be safely resected, with 5-year survival rates of 29% to 58%.7,8 In 1 series,7 17 of 30 patients required 3 or more resections. …"
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31
A marking technique for intraoperative localization of small liver metastases before systemic chemotherapy
منشور في 2009"…Preoperative chemotherapy is increasingly used prior to resection of colorectal liver metastases (CLM). …"
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32
Repeat hepatectomy for recurrent colorectal liver metastases is associated with a high survival rate
منشور في 2011"…Background: The outcome after a repeat hepatectomy for recurrent colorectal liver metastases (CLM) is not well defined. The present study examined the morbidity, mortality and long-term survivals after a repeat hepatectomy for recurrent CLM. …"
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33
Body surface area and body weight predict total liver volume in Western adults
منشور في 2002"…Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. …"
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34
Artificial Intelligence for Detecting and Quantifying Fatty Liver in Ultrasound Images: A Systematic Review
منشور في 2022"…Conclusion: AI-supported systems show potential performance increases in detecting and quantifying steatosis, NASH, and liver fibrosis in NAFLD patients. …"
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
منشور في 2022"…Monotherapy with CBD demonstrated a dose-dependent tumor growth inhibition at 72h, with the IC50 being 12.5 μg/ml for OVCAR-3 cell line and 12.3 μg/ml for SK-OV-3 cell line. The IC50 of cisplatin against OVCAR-3 and SK-OV-3 cell lines (1.1 and 3.3 μg/ml, respectively), and that of paclitaxel against SK-OV-3 cell line (9.9 μg/ml) were obtained as well. …"
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masterThesis -
36
Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines
منشور في 2016"…The zeta potential of linoleic had a greater negative value than that of Intralipid.Loading efficiencies for paclitaxel were 70.4–80.2% and 44.2–57.4% for Clinoleic and Intralipid formulations, respectively. …"
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37
Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model
منشور في 2019"…Although no single sign of cardiotoxicity was observed upon exposure to 200 mg/L of ChNPs, as judged by heartbeat rate, the corrected QT interval (QTc, which measures the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle), maximum cardiac arrest, and ejection fraction assays, the same dosage elicited the impairment of both liver size (decreased liver size, but without steatosis and lipid yolk retention) and neurobehavioral activity (increased movement under different light conditions). …"
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Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles
منشور في 2011"…In contrast, a decrease in methylation was observed in estrogen-treated T47-Kbluc cell lines strongly expressing estrogen receptor. …"
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Assessment of tropospheric NO<sub>2</sub> concentrations over greater Doha using Sentinel-5 TROPOspheric monitoring instrument (TROPOMI) satellite data: Temporal analysis, 2018–202...
منشور في 2024"…<p dir="ltr">This study presents a temporal evaluation of the tropospheric NO<sub>2</sub> column densities over Greater Doha using TROPOMI satellite data from May 2018 to December 2023, and an assessment of the impact of the preparations and hosting of the FIFA Football World Cup Qatar 2022, on NO<sub>2</sub> levels before, during and after the tournament over Greater Doha. …"
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Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)
منشور في 2004"…Interestingly, we have recently observed an increase in hepatocyte apoptosis with administration of TPN. …"
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