-
41
Novel proteins implicated in lipid metabolism disorders
Published 2016“…</p><p>ANGPTL3 is a protein secreted by the liver, belonging to the angiopoietin-like family of eight proteins. …”
-
42
-
43
Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet
Published 2011“…Non-alcoholic fatty liver disease (NAFLD) is one of the commonest liver diseases in Western countries. …”
Get full text
Get full text
Get full text
Get full text
article -
44
Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: Results of a multicenter study
Published 2004“…Of these, 53 (43%) died of recurrence, 30 (24%) of post-operative complications, and 40 (33%) of liver failure/hemorrhage. On multivariateanalysis, tumor size greater than 5 cm (P < 0.02; odds ratio, 3.0), multiple tumors(P < 0.01; odds ratio, 3.3), and greater than 5 mitoses per 10 high-power fields(P < 0.03; odds ratio, 3) were associated with increased risk of early death due torecurrence.Conclusions: These findings enable identification of patients with HCC who are athigh risk for early death due to recurrence following potentially curative resection whomight be candidates for adjuvant therapy trials.…”
Get full text
Get full text
Get full text
article -
45
Bevacizumab Improves Pathologic Response and Protects Against Hepatic Injury in Patients Treated With Oxaliplatin-Based Chemotherapy for Colorectal Liver Metastases
Published 2007“…The current study evaluated the effect of bevacizumab added to fluoropyrimidine-plus-oxaliplatin (5FU/OX) chemotherapy for colorectal liver metastases (CLM) on the pathologic response and nontumorous liver histology. …”
Get full text
Get full text
Get full text
article -
46
-
47
-
48
Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepat...
Published 2010“…Rubbia-Brandt L, Lauwers G Y, Wang H, Majno P E, Tanabe K, Zhu A X, Brezault C, Soubrane O, Abdalla E K, Vauthey J-N, Mentha G & Terris B (2010) Histopathology56, 430–439 Sinusoidal obstruction syndrome and nodular regenerative hyperplasia are frequent oxaliplatin-associated liver lesions and partially prevented by bevacizumab in patients with hepatic colorectal metastasis Aims: Because of its efficacy, oxaliplatin (OX) is increasingly used as a chemotherapeutic agent in the treatment of colorectal liver metastases (CRLM). …”
Get full text
Get full text
Get full text
article -
49
Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic...
Published 2021“…MG activated the intrinsic pathway of apoptosis, with decrease of mitochondrial and spliceosomal proteins. …”
-
50
An investigation into links between UAE STI Policy and the Federal Universities STEM Majors’ Enrolments, Graduates and Research Development: an evidence-based exploration of the im...
Published 2020“…Zayed University-Dubai had greater STEM majors’ enrolments compared to Zayed University-Abu Dhabi. …”
Get full text
-
51
Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats
Published 2020“…Moreover, these extracts, mainly the hydroxytyrosol-rich extract, reduced the elevated liver enzymes, enhanced the antioxidant status, and attenuated the liver inflammation and apoptosis. …”
-
52
Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study
Published 2024“…Hepatic glucose output increased from 0.6 (0.5–0.7) to 1.5 (1.3–1.7) mmol/min, while arterial lactate increased from 0.8 (0.7–0.9) to 9.0 (8.1–9.9) mmol/L (<i>P</i> < 0.05) despite a rise in hepatic lactate uptake. …”
-
53
The Superiority of T2*MRI Over Serum Ferritin in the Evaluation of Secondary Iron Overload in a Chronic Kidney Disease Patient: A Case Report
Published 2021“…Currently, T2*MRI of the heart and liver is the preferred investigation for evaluating liver iron concentration (LIC) and cardiac iron concentration, which reflect the state of iron overload. …”
-
54
The Photocatalytic Degradation of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Presence of Silver–Titanium Based Catalysts
Published 2020“…Byproducts of degradation were evaluated using Gas chromatography/mass spectrometry (GC–MS), resulting in 2,3,7-trichlorodibenzo-p-dioxin, a lower chlorinated congener and less toxic, as the main degradation product. Enzyme Linked Immunosorbent Assay (ELISA) was used to evaluate the relative toxicity of the degradation byproducts were a decrease in optical density indicated that some products of degradation could be potentially more toxic than the parent TCDD. …”
Get full text
article -
55
Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31
Published 2020“…RT-qPCR assays revealed that LRRK2 transcripts were dramatically reduced in our microdeletion patient DGDP289A compared to his healthy grandfather with no deletion. The decreased expression of LRRK2 may affect protein–protein interactions between LRRK2 and its binding partners, of which eight have previously been linked to intellectual disability. …”
-
56
-
57
Downregulation of <i>CYP17A1</i> by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties
Published 2022“…Methods: Chimeric mice with humanized liver were treated with 20-hydroxyecdysone for 3 days, and hepatic steroidogenic pathway genes and plasma progesterone were measured by transcriptomics and GC–MS/MS, respectively. …”
-
58
Efficient Detection of Hepatic Steatosis in Ultrasound Images Using Convolutional Neural Networks: A Comparative Study
Published 2023“…<h3>Introduction</h3><p dir="ltr">Artificial Intelligence (AI) is widely used in medical studies to interpret imaging data and improve the efficiency of healthcare professionals. Nonalcoholic fatty liver disease (NAFLD) is a common liver abnormality associated with an increased risk of hepatic cirrhosis, hepatocellular carcinoma, and cardiovascular morbidity and mortality. …”
-
59
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
Published 2023“…<h3>Background</h3><p dir="ltr">Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD).</p><h3>Objective</h3><p dir="ltr">The study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) with dyslipidemia and increased susceptibility risks of CVD, NAFLD, and/or T2DM in dyslipidemia patients in comparison with healthy control individuals from the Qatar genome project.…”
-
60
