Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells by Al Sayyed, Fatima

“…In this study, we investigate the efficacy of two small molecules Ruxolitinib, a JAK/STAT inhibitor, and CHIR-99021, a GSK-3 inhibitor, in targeting pediatric neuroblastoma stem cells by testing them on human MYC-N amplified, IMR-32, and non-MYC-N amplified, SK-N-SH, cell lines. Treating neuroblastoma cells with Ruxolitinib and CHIR-99021 resulted in significant reduction in cellular proliferation, viability, apoptosis and tumorsphere formation capacity in both IMR-32 and SK-N-SH cell lines. …”
Get full text
Get full text
Get full text

A control algorithm to increase the efficient operation of wind energy conversion systems under extreme wind conditions by Nyam Jargalsaikhan (17380429)

“…<p dir="ltr">This paper aims to increase the power production of gearless permanent magnet synchronous generator (PMSG) based wind energy conversion systems (WECS) in strong (greater than 25 m/s) wind speed regions. In general, most wind turbines cut off when wind speed is over the cut-out rate; as a result, the power generation of the wind farm decreases. …”

Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon by Mokhbat, Jacques M.

“…Introduction: Antiretroviral therapy (ART) has been successful at decreasing the morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. …”
Get full text
Get full text
Get full text
Get full text

Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells by Castellino, R.C.

“…However, sunitinib did not induce apoptosis in either cell line at any time point, indicating that the anti-migratory effects of sunitinib were not due to impeding cell survival. …”
Get full text
Get full text
Get full text
Get full text

Macular ultrastructural features in amblyopia using high-definition optical coherence tomography by Al-Haddad, Christiane Elias

“…Enhanced high-definition single line macular scans of amblyopic eyes were obtained using SD-OCT and compared with fellow eyes. …”
Get full text
Get full text
Get full text
Get full text

In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation by Sleiman, Sama F.

“…We validated the use of a reporter containing the oxygen-dependent degradation domain of HIF-1α fused to firefly luciferase (ODD-luc) to monitor quantitatively distinct biochemical events leading to hypoxic HIF-1α expression or stabilization in a human neuroblastoma cell line (SH-SY5Y). When OGD was imposed following a 2-hr hypoxic stabilization of ODD-luc, the levels of the reporter were reduced, consistent with prior models proposing that OGD enhances HIF prolylhydroxylase (PHD) activity. …”
Get full text
Get full text
Get full text

Maternal Body Mass Index and Recommended Gestational Weight Gain in a Middle Eastern Setting by Tawa Olukade (11619453)

“…</p><h3>Results</h3><p dir="ltr">The mean maternal age was 29.7 ± 5.5 years, prepregnancy BMI was 27.5 ± 5.8 kg/m2, GWG was 9.58 kg ± 6.87 kg and gestational age at birth was 38.5 ± 1.9 weeks. In line with IOM recommendations, we found that higher BMI was correlated with decreased GWG and BMI was significantly associated with GWG even after adjusting for maternal age, parity, and infants’ gestational age at birth. …”

Research on the potential of photovoltaic technologies in reducing energy consumption in an urban mixed use residential community. A Case study for net zero energy community in Dub... by SUGATHAN, SANAL

“…Therefore, the key challenge is to reduce the consumption of fossil fuels which decreases the production of greenhouse gases such as CO2 and CH4 by using renewable energy technologies to provide clean carbon free energy that can combat future energy security challenges. …”
Get full text

Solar syngas production via methanothermal reduction of strontium oxide by Rahul R. Bhosale (6467102)

“…Application of heat recuperation considerably decreased the requirement of solar energy input, and hence the process efficiency is further amplified. …”

Potent anti-tumor promoting effects of Daucus carota oil extract in mice by Abou Zeinab, RM

“…Inraperitoneal treatment inhibited tumor yield by 43%, and decreased the tumor volume by 85% at week 20. Gavage treatment failed to inhibit the promotion of tumors but decreased tumor volume by 20%. …”
Get full text
Get full text
Get full text
Get full text

The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B... by Saeid Safiri (3713035)

“…Globally, colorectal cancer accounted for 896 000 (876 300–915 700) deaths in 2017, with an age-standardised death rate of 11·5 (11·3–11·8) per 100 000 person-years, which decreased between 1990 and 2017 (−13·5% [–18·4 to −10·0]). …”

Hearing loss prevalence and years lived with disability, 1990–2019: findings from the Global Burden of Disease Study 2019 by Lydia M Haile (9715382)

The effect of StarD13 on colorectal cancer proliferation and invasion. (c2013) by Nasrallah, Anita I.

Get full text
Get full text

ROS-Mediated Autophagic Death in Glioblastoma Cells Upon Treatment by Human Recombinant Arginase I (Co)- PEG5000 [HuArgI (Co)-PEG5000] by Abdel Khalek, Maya

“…In this study, we examine the mechanism of HuArgI (Co)-PEG5000-induced cell death in both partially and completely auxotrophic GBM cell lines. Our results first showed a significant increase in HuArgI (Co)-PEG5000 treated cells for both U251 and A172 in autophagosome formation; suggesting activation of autophagy in response to arginine deprivation. …”
Get full text
Get full text
Get full text

Deep Learning-Based Fault Diagnosis of Photovoltaic Systems: A Comprehensive Review and Enhancement Prospects by Majdi Mansouri (16869885)

“…These faults may affect the different system components such as PV modules, connection lines, converters/inverters, which can lead to a decrease in the efficiency, performance, and further system collapse. …”

Cytotoxicity of Arginine Deprivation to AML Cells is Mediated by Autophagy by Taki, Fatima

“…[HuArgI(Co)-PEG5000]-induced arginine deprivation led to significant and sustained activation of autophagy starting at 24 hours and lasting up to 120 hours following arginine deprivation in all cell lines. Inhibition of autophagy, using chloroquine, led to a significant decrease in cell cytotoxicity evident at 48 hours and up to 120 hours. …”
Get full text
Get full text
Get full text

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes by Maryam Aghadi (17128819)

“…Here, we used FOXA2−/−iPSC lines to understand the role of FOXA2 on the development and function of human hepatocytes. …”

Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment by Christos Fountoukis (4722963)

“…The model’s forecast accuracy was assessed against measurement data from five ground air quality monitoring stations in the greater metropolitan area of Doha over a one-month period. …”

The Effects of Online Formative and Summative Assessment on Test Anxiety and Performance: A Study Among First-Year Undergraduate Students at A Higher Education Institution in Abu D... by ALSUWAIDI, MUNA

“…The presented study was conducted to provide greater insight into the potential positive, neutral and/or negative effects of online formative and summative assessment on test anxiety and performance. …”
Get full text

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration by Ayat S. Hammad (9592374)

“…In contrast, Orai1-KO cells, which have similar levels of SOCE inhibition as STIM1-KO, migrate slower than the parental cell line. This shows that the enhanced migration phenotype of STIM1-KO cells is not due to the loss of Ca²⁺ entry through SOCE, rather it involves transcriptional remodeling as elucidated by RNA-seq analyses. …”