The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) حسب Varghese P. Inchakalody (14557382)

"…We also observed the differential expression of protein Complement C3 (3.3-fold), Destrin (−5.1-fold), Vimentin (−1.7-fold), Peroxiredoxin 4 (−1.6-fold), Fascin (−1.8-fold), Heme oxygenase-2 (−0.67-fold**p < 0.0055), Hsp27 (−0.57-fold**p < 0.004), and Hsp70 (−0.39-fold **p < 0.001), indicating reduced cell growth, cell migration, and metastasis. …"

Acute pain management and assessment حسب Zeitoun, Abeer A.

"…Methods  A Lebanese multi-centre, prospective, chart review study was conducted over a period of 3 months. Data on demographics, pain medication, dose, route, duration and adjunct pain management were collected. …"
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Experimental and Analytical Investigations of the Use of Groove-Epoxy Anchorage System for Shear Strengthening of RC Beams Using CFRP Laminates حسب Mohamed, Khalid Mustafa Elradi

"…Generally, the contributions of groove-epoxy on shear-strength decreased with the increase of groove width. Moreover, shear strength prediction models, based on modifications of the ACI440.2R-17 shear model, were developed by incorporating groove factors as a modifier to the FRP shear-strength contribution. …"
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P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis حسب Milane, Aline

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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation حسب Mai S., El-Shoukrofy

"…Compound 2a activated PPARγ with an EC50 value of 3.4 μM in a Gal4-hybrid reporter gene assay, indicating partial agonistic action. …"
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PSA-activated proaerolysin as a prostate specific cancer therapy حسب Abi-Habib, Ralph

"…Activity toward proaerolysin was decreased 10-100 fold for each of the proteases tested except PSA, which showed a 4-fold increase in activity against the modified protein. …"
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Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro حسب Najem, Sonia A.

"…Results: Our results showed that SAHA and DAC, separately, significantly decreased cell proliferation, induced apoptosis and cell cycle arrest of Caco-2 cell line. …"
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Solar Technology and District Cooling System in a Hot Climate Regions: Optimal Configuration and Technology Selection حسب Rabah Ismaen (18387189)

"…The PV-DCS configuration is economically competitive among the solar assisted cooling systems, and it can contribute to reducing the environmental impact by 58.3%. The PVT-DCS configuration has the lowest operation cost and the highest environmental performance by decreasing the global warming potential by 89.5%. …"

Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity حسب Mohammed R. Shaker (10316180)

"…Our data reveal that upregulation of <i>KLOTHO</i> significantly reduced β-amyloid-induced neuronal degeneration and apoptosis, as evidenced by decreased cleaved caspase-3 expression and preservation of axonal integrity. …"

Applications of bioconvection for tiny particles due to two concentric cylinders when role of Lorentz force is significant حسب Lei Zhang (38117)

"…The graphical simulations are performed for flow parameters with specific range like 1≤Re≤5, 1≤Ha≤5, 0.5≤Nt≤2.5, 1≤Nb≤3, 0.2≤Sc≤1.8, 0.2≤Pe≤1.0 and 0.2≤Ω≤1.0. It is observed that the flow velocity decreases with the increase in the Hartmann number that signifies the magnetic field. …"

Wind shear coefficient, turbulence intensity and wind power potential assessment for Dhulom, Saudi Arabia حسب Rehman, Shafiqur

"…Furthermore, lower values were obtained during November to March and higher during rest of the year. Finally, a decreasing pattern was observed in the values of TIs with increasing height.…"
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In-Vehicle Performance Validation of the Semi-Active Hybrid Energy Storage System حسب Rehman, Habib-ur

"…The UCs supply the dynamic component of the load current which decreases the battery size, limits the battery peak current, and extends its life. …"
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Composite hydrogels from carrageenan-cl-carboxymethyl chitosan–PVA incorporated ZiF-8 as dressing material for wound healing applications حسب Tooba Yasin (19131382)

"…It was found that increasing ZiF-8 decreases the swelling in different media and increases degradation in PBS media. …"

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss حسب Meritxell Espino Guarch (18810097)

"…The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. …"

The Trace Element Composition of Size Fractionated Suspended Particulate Matter Samples from the Qatari EEZ of the Arabian Gulf: The Role of Atmospheric Dust حسب Oguz Yigiterhan (14151006)

"…Because surface seawater is supersaturated with respect to CaCO3 and acid soluble Ca is abundant in the particulate matter, we only used unleached dust for the lithogenic correction. …"

Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells حسب Mohamed Qasim Al-Fahdawi (17844209)

"…Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. …"

Evaluation of Lycopus uniflorus water extract for anti-inflammatory, anti-ulcerogenic and antioxidant activities حسب Saade, S.

"…No studies were conducted on Lycopus uniflorus, but other species were reported to possess anti-allergic [1], anti-inflammatory [2], antihyperthyroidism [3], Yarnell and Abascal, 2006 E. Yarnell and K. …"
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Drug Resistance Induction and Phenotypic and Genotypic Characterization of a Candida albicans Drug Sensitive Isolate حسب El Hachem, Setrida Charbel

"…Furthermore, whole genome sequencing data revealed mutations in genes involved in resistance and pathogenicity attributes such as ERG11, CHS3, GSC2, CDR2, CRZ2, and MSH2. Some of these mutations were previously documented and many are novel undocumented mutations in key genes. …"
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Nebulized fentanyl for respiratory symptoms in patients with COVID-19 (ventanyl trial) حسب Nissar Shaikh (11659441)

"…The proposed theory behind that was that fentanyl decreased the rate of spontaneous respiratory rate, diminished the brain stem chemoreceptor response to hypoxia and hypercarbia, in addition to exhibiting a modulating effect on the brain stem. …"

Road safety and traffic medicine in Iran: Achievements and challenges حسب A. Motevalian (19807242)

"…The number of annual fatalities, which had been on the rise for several decades, reached to the maximum number of over 27500 deaths in 2005. The number decreased to 23000 in 2010 and less than 18000 in 2013. …"