Reply to Comments by Kakkar and Dahiya by Chahine, Elias B.

“…Initial reports describing the use of bedaquiline in patients with MDR-TB and extensively drug-resistant TB are promising.3,4 Fortunately, the World Health Organization (WHO) has recently issued an interim policy guidance recommending that bedaquiline may be added to a WHO-recommended regimen in adult patients with MDR-TB when an effective regimen containing 4 second-line drugs in addition to pyrazinamide cannot be designed, and when there is documented evidence of resistance to any fluoroquinolone in addition to multidrug resistance.5 Similarly, the Centers for Disease Control and Prevention (CDC) has also issued provisional guidelines recommending that bedaquiline may be used for 24 weeks in adults with laboratory-confirmed pulmonary MDR-TB when an effective regimen cannot otherwise be provided; on a case-by-case basis in children, persons with HIV, pregnant women, persons with extrapulmonary MDR-TB, and patients with comorbidties when effective regimen cannot otherwise be provided; and on a case-by-case basis for durations longer than 24 weeks when an effective regimen cannot be provided.6 Both WHO and CDC emphasize the need for careful monitoring of patients on bedaquiline therapy for safety concerns.5,6 Until further data become available, the authors believe that patients who meet eligible criteria according to current guidelines may benefit from bedaquiline therapy with careful monitoring for potential side effects and drug interactions.…”
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Subsarcolemmal cAMP signals monitored by cyclic nucleotide gated channels in hypertrophied cardiac myocytes by Abi-Gerges, Aniella

“…In an attempt to address this question, 3 weeks-old rats were subjected to aortic coarctation (H) or sham operated (S). 5 weeks after surgery, the mass of the left ventricle to tibia length ratio was 59% increased in the H group compared to the S group while the right ventricle mass to tibia length ratio was unchanged, attesting compensated hypertrophy of the heart in H rats. …”
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Histopathologic analysis of transjugular intrahepatic portosystemic shunts by El-Khoury, Joe

“…This pseudo-intima extended with time as the myofibroblasts increased in number, as the collagen fibers thickened, and as the inflammatory cells grew more scarce. …”
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The promise of tirzepatide: A narrative review of metabolic benefits by Sara Sokary (17337724)

“…Moreover, tirzepatide exhibited favorable effects on glycemic control, with notable reductions in HbA1c levels ranging from 20.4 mmol/mol with the 5 mg dose to 28.2 mmol/mol with the 15 mg dose, following treatment durations lasting 40–52 weeks. Additionally, tirzepatide exerts a beneficial impact on lipid profile parameters, including reductions in total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels, while increasing high-density lipoprotein cholesterol concentrations. …”

Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis by George Nitzburg (18614989)

“…Second, we examined symptom queries preceding queries on the 12-step program at time lags of 0-7 days, 7-14 days, and 14-30 days, where the probability of asking about a medical symptom was greater in the 30-day time window preceding 12-step program information-seeking as compared to all previous times that the symptom was queried.…”

Effects of perinatal variables on echocardiographic assessments of left ventricular dimensions in infants born large for gestational age: a prospective cohort analysis by Ahmed Amarah (17733726)

“…Regression analysis identified birth weight (BW) as a key factor, positively correlating with increased LVmass, interventricular septum thickness, and LV posterior wall thickness in both LGA and AGA infants. …”

Investigation of Biochemical Alterations in Ischemic Stroke Using Fourier Transform Infrared Imaging Spectroscopy—A Preliminary Study by Fazle Rakib (5768069)

“…This study investigates the biochemical and molecular changes in peri-infract zone (PIZ) (contiguous area not completely damaged by stroke) and ipsi-lesional white matter (WM) (right below the stroke and PIZ regions) nine weeks post photothrombotic ischemic stroke in rats. …”

Petrophilic, Fe(III) Reducing Exoelectrogen Citrobacter sp. KVM11, Isolated From Hydrocarbon Fed Microbial Electrochemical Remediation Systems by Krishnaveni Venkidusamy (4950109)

“…Fe(III) reduction of 90.01 ± 0.43% was observed during 5 weeks of incubation with Fe(III) supplemented liquid cultures. …”

Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial by Kilany, Hala

“…Supplementation was associated with a 14.2% reduction in mean cfPWV at 8 weeks (cfPWV pre-vitamin K2 = 9.8 ± 2.2 m/s vs. cfPWV post-vitamin K2 = 8.4 ± 1.5 m/s; P < .001). …”
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Comparing WZB117-liposome Synthesis via Thin-film Hydration and Microfluidic Methods by Yaramiree, Atena

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Fixed Shading Scenarios to Optimize Lighting Performance and Energy Efficiency in Office Buildings Case Study of Dubai Design District by Hamad, Khadije

“…The annual energy consumption of the optimal scenario is reduced from 1670 MWh to 1532MWh in the Egg-crate scenario three, which is a high reduction of 138MWh per year. Moreover, daylighting analysis shows decreased average illuminance levels from 407.8 to 154.97 Lux, equivalent to a 60% reduction in December and June. …”
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Biodegradable polysaccharide grafted polyacrylamide inhibitor for corrosion in CO₂- saturated saline solution by Rem Jalab (11715205)

“…Nevertheless, the AGGPAM-inhibited solution exhibited a corrosion rate of 26.7 mils per year at 50 °C, which is still lower than that of blank at 25 °C. …”

Location matters: spatial dynamics of tumor-infiltrating T cell subsets is prognostic in colon cancer by Hehuan Zhu (4808445)

“…We demonstrated an increase in immune cell density and a decrease in the distance of CD3⁺CD8⁺ T cells to the nearest tumor cell, in the immune active, ICR High, immune subtypes. …”

Indoor Air Quality (IAQ) in labor housing in Dubai and its impact on ccupants' health by Nazzal, Saja Bassam

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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle by Jinit, Masania

“…We investigated protein glycation and oxidative damage in skeletal muscle of mice with UCP1 expression under control of the human skeletal actin promoter (HSA-mUCP1) at age 12 weeks (young) and 70 weeks (aged). We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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Hemodynamics of small aneurysm pairs at the internal carotid artery by Jou, Liang-Der

“…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…”
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Local Over-Expression of VEGF-DDNDC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis by Abi Nader, Khalil

“…Previously we showed that adenovirus (Ad)-mediated VEGF-A165 expression in the pregnant sheep uterine artery (UtA) increased nitric oxide synthase (NOS) expression, altered vascular reactivity and increased UABF. …”
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Safety and efficacy of ensifentrine in COPD: A systemic review and meta-analysis by Ambanna Yappalparvi (21260018)

“…Safety profiles were comparable between the ensifentrine and placebo groups, with no significant increase in treatment-emergent <u>adverse events</u> (TEAEs) (RR: 1.02; 95 % CI: 0.94–1.10). …”

Exaggeration of Non-Culprit Coronary Artery Stenosis in the Setting of Primary Percutaneous Coronary Intervention: A Single Center Observational Study by Fahmi Othman (14777506)

“…Compared to PPCI angiograms, the non-PPCI angiograms showed a statistically significant reduction in the percentage of stenosis (71.6± 14.4% vs 64.5± 14.4%, <i>p</i>≤ 0.001), and an increase in minimal luminal diameter (0.82± 0.45 mm vs 1.00± 0.44 mm, <i>p</i>≤ 0.001) of non-culprit lesion. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…Male and female KO and WT mice were fed a HF diet (45% kcal fat) for 16 weeks. Body weight was measured biweekly, and a glucose tolerance test (GTT) and insulin tolerance test (ITT) were conducted at week 13 and 14, respectively. …”