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1241
A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia...
منشور في 2004"…Novel agents to treat acute myeloid leukemia (AML) are needed with increased efficacy and specificity. We have synthesized a dual-specificity fusion toxin DTU2GMCSF composed of the catalytic and translocation domains of diphtheria toxin (DT) fused to the granulocyte-macrophage colony-stimulating factor (GM-CSF) in which the DT furin cleavage site 163RVRRSV170 is modified to a urokinase plasminogen activator (uPA) cleavage site 163GSGRSA170, termed U2. …"
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1242
Fermentation-induced modifications to the structural, surface, and functional properties of quinoa proteins
منشور في 2025"…Notably, fermentation significantly increases the digestibility of QPs from 78.13 to 85.24%, thereby enhancing their nutritional value. …"
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1243
Calibration of building model based on indoor temperature for overheating assessment using genetic algorithm: Methodology, evaluation criteria, and case study
منشور في 2022"…To do so, a building simulation model needs to be calibrated based on measured indoor temperatures under the current weather conditions. …"
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1244
Retrospective study and review of polymorphous low‐grade adenocarcinoma
منشور في 2006"…Conclusions: Polymorphous low‐grade adenocarcinoma is an increasingly recognized malignancy that originates predominantly in the minor salivary gland. …"
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1245
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1246
Methodological issues of systematic reviews and meta-analyses in the field of sleep medicine: A meta-epidemiological study
منشور في 2021"…<p dir="ltr">An increasing number of systematic reviews and meta-analyses (SRMAs) have been published in the field of sleep medicine. …"
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1247
The role of preoperative transfusion in sickle cell disease, a systematic review and meta-analysis
منشور في 2024"…Preoperative transfusion in SCD was associated with a higher bleeding risk but a similar risk in other outcomes compared to conservative strategies. Notably, the increased bleeding risk observed seldom had clinical significance. …"
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1248
Liquified hydrogen vs. liquified renewable methane: Evaluating energy consumption and infrastructure for sustainable fuels
منشور في 2023"…Moreover, the qualitative results indicate that the infrastructure is ready, and regulations are available to use liquefied renewable methane as fuel, whereas the infrastructure of liquified hydrogen still needs to be ready, and the associated regulations require amendments.…"
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1249
Advancements of 2D Materials-Based Membranes
منشور في 2021"…<p dir="ltr">Our environment desperately needs creative solutions to limit the effect of industrialization’s fast rise and, consequently, to remediate vast amounts of harmful by-products and toxic exhausts. …"
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1250
Speech and Language Disorders: A systematic review of corpora and future directions
منشور في 2026"…According to data published by Komodo Health, speech disorder diagnoses among children aged 0–12 increased by 110% in 2022, reaching 1.2 million cases compared to the pre-pandemic average of 570,000. …"
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1251
A review of movement disorders in chemotherapy-induced neurotoxicity
منشور في 2021"…More studies are needed that use objective measures of sensorimotor function to better characterize movement disabilities and investigate the underlying causes, as required for developing targeted assessments and interventions. …"
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1252
Adaptive response for climate change challenges for small and vulnerable coastal area (SVCA) countries: Qatar perspective
منشور في 2023"…Along with mitigation efforts, adaptive response actions are gaining increasingly urgent importance for many regions to considerably reduce the most severe impacts of climate change on social and physical infrastructure. …"
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1253
Impact of Charging Electric Vehicles under Different State of Charge Levels and Extreme Conditions
منشور في 2021"…To solve this problem, an original algorithm is suggested that is able to adapt the constraints’ limits according to the energy demand and the energy needed to charge the PEVs. Different case scenarios are studied for validation purposes, such as charging PEVs under different state of charge levels, different energy demands at home, and different pricing mechanisms. …"
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1254
Towards Grid of Microgrids: Seamless Transition between Grid-Connected and Islanded Modes of Operation
منشور في 2020"…<p dir="ltr">With the ever-increasing number of blackouts in distribution systems arising from a variety of natural and manmade disasters, the frequent and necessary isolation/reconnection of loads without power deviations/fluctuations has become an important issue. …"
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1255
Voltage Lift Switched Inductor Double Leg Converter With Extended Duty Ratio for DC Microgrid Application
منشور في 2021"…<p>In a DC microgrid, while integrating the low voltage sources such as Fuel cells and photovoltaics, an efficient DC-DC converter is crucially needed. Contributing to a high voltage whilst being operated on a low duty ratio is among the demanded features of the converter. …"
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1256
The Safety of Novel Therapies in Chronic Lymphocytic Leukemia in the Era of Intermittent Fasting: A Pharmacology-Based Review
منشور في 2024"…Unfortunately, it is unclear whether the associated risks of tumor lysis syndrome (TLS) and gastrointestinal bleeding (GIB) are increased in IF practitioners receiving NAs. This review explored the literature available on the permissibility of IF in CLL patients undergoing treatment with first-line NAs (FLNAs). …"
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1257
Factors Associated with Meeting Current Recommendation for Physical Activity in Scottish Adults with Diabetes
منشور في 2019"…Implementation of health promotion programs that target the identified determinants is needed to improve the recommended levels of physical activity among adults with diabetes.…"
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1258
Spatial patterns of reef fishes and corals in the thermally extreme waters of Qatar
منشور في 2022"…However, further temperature increases may push both fishes and corals over their physiological limits. …"
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1259
Challenges and constraints in meeting international standards in UAE education: External objectives versus local realities
منشور في 2015"…<p dir="ltr">The purpose of this paper is to examine some of the challenges faced by a private university in the United Arab Emirates in balancing the specific needs of the country's educational system with the requirements of both national reporting measures and international accreditation. …"
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1260