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461
Single-Cell Transcriptome Analysis Revealed Heterogeneity and Identified Novel Therapeutic Targets for Breast Cancer Subtypes
منشور في 2023"…Mechanistically, targeted depletion of ENO1 and FDPS halted TNBC cell proliferation, colony formation, and organoid tumor growth under 3-dimensional conditions and increased cell death, suggesting their potential use as novel therapeutic targets for TNBC. …"
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462
A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle
منشور في 2022"…These observations were complimented by the 100 ns molecular dynamics simulation and binding free energy analysis, which showed a considerable stability of docked bioflavonoids in the active site of SARS-CoV-2 target proteins. …"
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463
Deep learning-based cross-device standardization of surface-enhanced Raman spectroscopy for enhanced bacterial recognition
منشور في 2026"…Quantitative results show that SERS-D2DNet reduced mean absolute error to 0.01 and increased R<sup>2</sup> to over 98 % across devices, while SuperRaman achieved up to 100 % classification accuracy post-transformation. …"
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464
Attitudes, motivators, and barriers toward influenza vaccination for children: a study from a conflict-ridden country
منشور في 2024"…<h3>Background</h3><p dir="ltr">Despite the increased recommendations for influenza vaccination, particularly among high-risk groups such as young children, Yemen lacks an influenza vaccination program, and the influenza vaccine is not included in the national immunization regime. …"
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465
Experimental and modeling analysis of p-type Bi<sub>0</sub>.<sub>4</sub>Sb<sub>1</sub>.<sub>6</sub>Te<sub>3</sub> and graphene nanocomposites
منشور في 2022"…The GNS addition has increased the output power of pristine Bi<sub>0.4</sub>Sb<sub>1.6</sub>Te<sub>3</sub> by 7%, leading to comparable TE performance to other simulated Bi<sub>2</sub>Te<sub>3</sub> systems.…"
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466
Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications
منشور في 2019"…High expression of <i>CCL5</i> in breast tumors was significantly associated with an increased OVS in all BC patients, but particularly in TNBC/Basal-like patients. …"
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467
Novel proteins implicated in lipid metabolism disorders
منشور في 2016"…</p><p>ANGPTL4 is a protein that is activated during fasting, decreasing the release of free fatty acids from circulating triglyceride-rich lipoproteins. …"
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468
Can Ease of Doing Business Shorten the Distance and Attract Foreign Direct Investment
منشور في 2021"…Abstract Due to the accelerating pace of globalization, Multinational Enterprises (MNEs) have increasingly employed foreign direct investment (FDI) to enter foreign markets. …"
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469
Liver resection for liver metastases from nondigestive endocrine cancer
منشور في 2012"…After median follow-up of 20 months (range, 1–144), the 5-year overall and recurrence-free survival rates were 58% and 37%, respectively. …"
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470
Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4
منشور في 2023"…Then starved the cells for 6h in DMEM containing 1% fatty-acid-free bovine serum albumin. Following the starvation, a 16h incubation in DMEM containing increasing concentrations of OA (0–500 µM) at 37 °C was performed, and steatosis was quantified by triglycerides quantification, Bodipy staining, and quantification of the expression of perilipin genes family. …"
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471
Physical and chemical properties of black carbon and organic matter from different combustion and photochemical sources using aerodynamic aerosol classification
منشور في 2021"…The dynamic shape factor (χ) of BC particles and material density (ρ<sub>m</sub>) of organic aerosols was investigated by coupling a charging-free Aerodynamic Aerosol Classifier (AAC) with a Centrifugal Particle Mass Analyzer (CPMA) and a Scanning Mobility Particle Sizer (SMPS). …"