Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes حسب Maryam Aghadi (17128819)

"…Here, we used FOXA2−/−iPSC lines to understand the role of FOXA2 on the development and function of human hepatocytes. …"

Is board compensation excessive? حسب Dah, Mustafa A.

"…Based on this, we then calculate whether directors of corporate boards are over- or undercompensated. On average, we find greater evidence of over- rather than undercompensation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Characterization of the Potency and Mechanism of Action of a Novel Dual-Selective Intermolecularly Complemented Version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Breas... حسب Basala, Sobhiya

"…Results show that UACC-2087 cell line expresses the three proteases and upon treatment, the levels of expression were not consistent. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Cytotoxicity of Anthrax Lethal Toxin to Human Acute Myeloid Leukemia Cells Is Nonapoptotic and Dependent on Extracellular Signal-Regulated Kinase 1/2 Activity حسب Abi-Habib, Ralph J.

"…We tested potency of LeTx on a panel of 11 human AML cell lines. Seven cell lines showed cytotoxic responses to LeTx. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Do high energy-efficient buildings increase overheating risk in cold climates? Causes and mitigation measures required under recent and future climates حسب Mutasim Baba, Fuad

"…While without adequate ventilation, the overheating risk in high-energy-efficient buildings can be higher than old buildings, where decreasing wall and window U-values and infiltration rate has a greater contribution to the increase of indoor temperature, while decreasing window SHGC has a lower contribution to the decrease in indoor temperature compared to the case with adequate ventilation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors حسب Gaur, Puja

"…We sought to identify gastrointestinal neuroendocrine CSCs (N-CSCs) in surgical specimens and a NET cell line and to characterize novel N-CSC therapeutic targets. …"
احصل على النص الكامل
احصل على النص الكامل

Gaining or Losing Team Ball Possession: The Dynamics of Momentum Perception and Strategic Choice in Football Coaches حسب Walid Briki (688845)

"…Nonetheless, both variables displayed asymmetrical effects, in the sense that: (1) the strength of positive PM appeared to be easier to decrease than to increase; and (2) the greater the positive PM (or the negative PM), the lesser (or the greater) the coaches’ tendency to make a change in the organization of their teams. …"

Effect of consanguinity on birth weight for gestational age in a developing country حسب Wakim, Gerard

"…No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways حسب Daaboul, Hamid E.

"…The SW1116 colon cancer cell line was treated with HC (1, 5, 10 and 25 μg/ml) and cell viability was evaluated with WST 1 assay kit. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The mechanisms of resistance of anthrax lethal toxin (LeTx)-induced cytotoxicity in AML cells. (c2018) حسب Abou Harb, Monica

"…Our results indicate that vertical inhibition by SCH772984 rendered the resistant cell lines sensitive to the inhibition of the MAPK-pathway and showed an increased cytotoxic effect once used in combination with anthrax lethal toxin compared to the use of anthrax lethal toxin alone.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The mechanism of action of kefir and its effect on the motility of breast and colorectal cancer cells. (c2013) حسب Khoury, Nathalie El

"…Western blot assay results confirmed the previously observed increase in apoptosis as it showed an increase in Bax:Bcl-2 expression upon kefir treatment. …"
احصل على النص الكامل
احصل على النص الكامل

Power System Transient Stability Assessment Based on Machine Learning Algorithms and Grid Topology حسب Senyuk, Mihail

"…Features of transmission line maintenance were used to increase accuracy of estimation. …"
احصل على النص الكامل

Comparative Effect of Sodium Butyrate and Sodium Propionate on Ovarian Cancer Migration, Invasion, and Epithelial-To-Mesenchymal Transition حسب Sleem, Reem

"…Methodology: The two ovarian cancer cell lines, SKOV-3 and PA-1, were treated with NaB and NaP for 24h. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells حسب Al Sayyed, Fatima

"…In this study, we investigate the efficacy of two small molecules Ruxolitinib, a JAK/STAT inhibitor, and CHIR-99021, a GSK-3 inhibitor, in targeting pediatric neuroblastoma stem cells by testing them on human MYC-N amplified, IMR-32, and non-MYC-N amplified, SK-N-SH, cell lines. Treating neuroblastoma cells with Ruxolitinib and CHIR-99021 resulted in significant reduction in cellular proliferation, viability, apoptosis and tumorsphere formation capacity in both IMR-32 and SK-N-SH cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Targeting potential arginine auxotrophy in glioblastoma (GBM) cells using human recombinant arginase I (CO)-PEG 5000 [HuArgl (Co)-PEG5000]. (c2013) حسب Khoury, Oula

احصل على النص الكامل
احصل على النص الكامل

Guidelines for the pharmacological treatment of peripheral neuropathic pain حسب Riachi, N.

"…The expert panel recommended pregabalin, gabapentin and secondary amine tricyclic antidepressants (nortriptyline and desipramine) as first-line treatments for peripheral NeP. Serotonin-norepinephrine reuptake inhibitor antidepressants, tramadol and controlled-release opioid analgesics were recommended as second-line treatments. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The July war and its effects on Lebanon’s power-sharing حسب Fakhoury, Tamirace

"…On a broader scale, this article helps shed light on the dilemma of power-sharing systems on stormy seas when external conflicts overlap with internal conflict lines.…"
احصل على النص الكامل

Effectiveness of communication processes in Agile Project Management Approach in the UAE Utility Sector حسب AFIFI, MUTASIM ABDALLA HASSAN

"…Team members should have a voice in the agile project management process, maintain open lines of communication with stakeholders, and discuss problems in a timely manner to increase tolerance and acceptance.…"
احصل على النص الكامل

Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance حسب Zouhaier Farhani (22330693)

"…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…"

Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes حسب Rizk, Sandra

"…The percent reduction in proliferation was very significant, and was dose-, and time-dependent. In both cell lines, kefir exhibited its antiproliferative effect by downregulating TGF-α and upregulating TGF-β1 mRNA expression. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل