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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien...
منشور في 2023"…We have demonstrated that baseline concentration of exosomal-PD-L1 (p<0.0001), exosomal-PD-L2 (p=0.0413) and exosomal-PD-1 (p=0.0131) from NSCLC patients were significantly higher than their soluble-free forms. Furthermore, the exosomal-PD-L1 was present in all the patients (100%), while only 71% of patients expressed tissue PD-L1. …"
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184
Board independance and the efficiency of internal capital markets
منشور في 2017"…However, the presence of independent directors increases costs associated with information asymmetry and free riding problems. …"
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185
Structure of a reattaching supersonic shear layer
منشور في 1990"…The preliminary results show that large-scale relatively organized structures with limited spanwise extent form in the free shear layer. Some of these structures appear to survive the recompression and reattachment processes, while others break down into smaller scales and the flow becomes increasingly three-dimensional. …"
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186
Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases
منشور في 2010"…For example, a few years ago an extrahepatic metastasis effectively eliminated surgical resection, but a combination of chemotherapeutic options and surgical techniques has expanded the indications for resection and increased the population of patients who may benefit.1,2 Neoadjuvant chemotherapy has increased the resectability rate by 11% to 37%.1 Unfortunately, greater than 80% of patients undergoing hepatic resection will have recurrences, mostly within the first 2 years.2 Nonetheless, the only hope for cure is resection, and prior surgical dogma based on the number of lesions, size of the tumor-free resection margin, and presence of resectable extrahepatic disease must be questioned.3- 5 The current standard approach to surgical planning is contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) for specific tumor characteristics or contraindications to CT.6 Several series showed that focal extrahepatic disease, an isolated pulmonary lesion, can be safely resected, with 5-year survival rates of 29% to 58%.7,8 In 1 series,7 17 of 30 patients required 3 or more resections. …"
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187
Giving fragile bones a stronger foothold
منشور في 2016"…Since age is a known risk factor for osteoporosis, incidences are destined to increase in these regions as the percentage of the population older than 50 rises to 40% by 2050. …"
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Economic policy uncertainty: Global energy security with diversification
منشور في 2024"…The quantitative results reveal the importance of clear and precise economic policies for increasing investment in carbon-free energy security.…"
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189
Serotonin distinctly controls behavioral states in restrained and freely moving Drosophila
منشور في 2023"…<p>When trapped in a physical restraint, animals must select an escape strategy to increase their chances of survival. After falling into an inescapable trap, they react with stereotypical behaviors that differ from those displayed in escapable situations. …"
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Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae
منشور في 2020"…Balamuthia mandrillaris and Naegleria fowleri are free-living amoebae that cause infection of the central nervous system, granulomatous amoebic encephalitis (GAE) and primary amoebic meningoencephalitis (PAM), respectively. …"
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191
Association between Healthy Lifestyle Index and Cognitive decline In Community- Dwelling Lebanese Older Adults
منشور في 2021"…Adopting a healthy lifestyle that constitute of following a healthy diet, consuming moderate alcohol amount, being physically active, maintaining a healthy BMI and never smoking is an important protective factor against cognitive decline. …"
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The distribution of toxic sources in Louisiana
منشور في 1993"…Furthermore, the greater the percentage of blacks in a community, the greater the reductions in discharges. …"
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195
Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults
منشور في 2022"…After three-months supplementation of 50,000IU, vitamin D levels increased to 51.41 ±11.27ng/ml in the supplemented group and to24.95 ±6.45ng/ml in placebo group (p=0.00). …"
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196
The antioxidant and anticancer effects of Wild Carrot oil extract
منشور في 2012"…Also, DCOE demonstrated a significant increase in cell death and decrease in cell proliferation. …"
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197
Complex structural contribution of the morphotropic phase boundary in Na0.5Bi0.5TiO3 - CaTiO3 system
منشور في 2019"…The fraction of orthorhombic phase increases gradually with x in the MPB region. Dielectric measurements reveal that the relative permittivity increase with addition of Ca2+. …"
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198
Comparative Study of Several Energy Dissipating Devices
منشور في 2011"…It is concluded that the energy absorbed for a given system decreases with the increase of the R ratio. It is recognized that the highest absorbed energy is obtained in the constrained situation with deformable non-deformable compared to the other situations. …"
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Dietary Curcumin Nanoparticles Improve Growth Performance, Oxidative Status and Immune Response of European Seabass (<i>Dicentrarchus Labrax</i>)
منشور في 2024"…Therefore, CURNPs could be supplemented in the diets of D. labrax as a natural alternative to promote overall performance.…"