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461
Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF)
منشور في 2020"…Our results demonstrate that vertical inhibition does offer increased potency in comparison to single targeting of the MAPK pathway when working with sensitive cell lines that are dependent on the cascade. …"
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masterThesis -
462
Foreign currency borrowing by small firms in emerging markets
منشور في 2013"…Bank relationships, however, do not increase the dollar debt likelihood. And finally, profitable firms are less likely to have dollar debt. …"
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article -
463
A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells
منشور في 2008"…Experimental Design The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …"
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article -
464
The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase
منشور في 2008"…Escherichia coli contains two thioredoxins, Trx1 and Trx2, and a thioredoxin-like protein, YbbN, which presents a strong homology in its N-terminal part with thioredoxins, and possesses a 20 kDa C-terminal part of unknown function. …"
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article -
465
Studying coral reef patterns in UAE waters using panel data analysis and multinomial logit and probit models
منشور في 2020"…Like coral reefs around the world, the reefs of the United Arab Emirates (UAE) are facing global climate change and associated threats. …"
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466
A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce...
منشور في 2008"…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …"
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article -
467
Effect of StarD13 on colorectal cancer proliferation, motility and invasion
منشور في 2014"…Colon cancer is a cancer of the epithelial cells lining the colon. It is mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. …"
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article -
468
Surveilling and Spying on Romantic Partners in the United States: The Influence of Perceived Maternal Rejection and Psychological Maladjustment
منشور في 2021"…IPARTheory predicts universal responses to perceived rejection or acceptance, making it important to explore its predictive ability with theoretically-related constructs like romantic relationships. Participants (N = 443; Mage = 36.05 years; SD = 11.26; 46% identifying as men, 45.4% reported their assigned sex at birth as male) completed surveys regarding perceptions of their childhood relationships with their mother, interpersonal anxiety, engagement in romantic surveillance, jealousy, infidelity, sociosexual orientation, and gender norms. …"
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article -
469
What’s So Great About Home?
منشور في 2008"…She is rejected in some Arab circles as non-authentic yet hailed in others as an Arab author, famous in both the West and the Arab world. Critics like Bettina Knapp locate Chedid within the French literary tradition, though her work is infused with Middle Eastern sensibility.2 In Sexuality and War: Literary Masks of the Middle East, Evelyne Accad labels Chedid as a writer of the Lebanese civil war and groups her with other women writers such as Etel Adnan and Hanan al-Shaykh, in contrast to male writers. …"
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article -
470
Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review
منشور في 2022"…Nonetheless, tuberculosis (TB) reactivation during their use is increasingly recognized and reported. Herein, we present a 58-year-old lady with advanced non-small cell lung cancer (NSCLC) ALK-negative, EGFR wild, and PD-L1 immune histochemistry (IHC) strongly positive in 95% of tumor cells, on ongoing treatment with Pembrolizumab as a first-line monotherapy. …"
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471
Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
منشور في 2021"…To date, immune check-point inhibitors have been approved as first or second line therapy options in a broadening range of metastatic cancer and increasingly explored in the treatment of early stage tumors. …"
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472
PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer
منشور في 2019"…In this study, we investigated the molecular mechanisms by which the human TNBC cell line MDA-MB-231, expressing PD-L1, responds to atezolizumab, using RNA-Seq. …"
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473
Need for Affect, Problematic Social Media Use and the Mediating Role of Fear of Missing Out in European and Arab Samples
منشور في 2023"…<h3>Purpose </h3><p dir="ltr">The growing awareness and concern about the excessive use of social media have led to an increasing number of studies investigating the underlying factors contributing to this behavior. …"
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474
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475
The impact of cultural diversity on project management communication
منشور في 2022"…The results of the study are in line with some previous research, who said that when examined in terms of age, gender, and ethnicity, having a diverse workforce has a positive impact on the organization's performance. …"
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476
Balanced scorecard in the hospitality and tourism industry: Past, present and future
منشور في 2020"…This is evidenced by the increasing number of publications addressing BSC and the large number of professional events devoted to it. …"
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477
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478
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479
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480
Cloud providers collaboration for a higher service level in cloud computing
منشور في 2013"…Cloud computing is increasingly becoming a desirable and foundational element in international enterprise computing. …"
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conferenceObject