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line » life (توسيع البحث), like (توسيع البحث), link (توسيع البحث)
give » given (توسيع البحث), five (توسيع البحث)
per » peer (توسيع البحث)
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581
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582
Tumor protease-activated fusion toxins
منشور في 2003"…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …"
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احصل على النص الكامل
masterThesis -
583
Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
منشور في 2023"…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …"
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584
Inositol 1,4,5-Trisphosphate Receptors in Hypertension
منشور في 2018"…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca<sup>2+</sup> signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP<sub>3</sub>R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …"
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585
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
منشور في 2021"…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …"
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586
A possible culprit for refractory angina
منشور في 2015"…</p><p>This may implicate lipoprotein(a) as having a causal role in refractory angina, but the findings still need to be confirmed by testing a control group of patients who have coronary heart disease but not refractory angina.</p><p>An increased lipoprotein(a) level is known to be highly heritable, and is believed to promote hardening of the arteries by trapping cholesterol in the inner linings of blood vessels, promoting clot formation, recruiting inflammatory cells, or binding pro-inflammatory phospholipids.…"
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587
Critical Success & Failure Factors for Public Private Partnership Projects in the UAE
منشور في 2008"…There were few PPP projects identified in the UAE, but the number is increasing. Most of them are under development phase and only two were completed and under operation. …"
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588
The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis
منشور في 2022"…Consequently, inactivation of SREBP1 in human liver and breast cancer cell lines reduces the expression of cyclin D1 and attenuates Rb phosphorylation. …"
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589
Optimizing microgrid efficiency: Coordinating commercial and residential demand patterns with shared battery energy storage
منشور في 2024"…Moreover, considering DTR for transmission lines, instead of fixed thermal rating, improves the PAR and DPS up to 28.52 % and 41.06 % respectively. …"
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590
Augmented Reality in Medical Practice: From Spine Surgery to Remote Assistance
منشور في 2021"…The accessibility of this information often relies on the physical presence of technical and medical specialists in the OR, which is increasingly difficult due to the number of limitations imposed by the COVID emergency to avoid overcrowded environments or external personnel. …"
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591
ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder
منشور في 2017"…<i>ACTB</i> mRNA expression levels in lymphoblastic lines and fibroblasts derived from affected individuals were decreased in comparison to those in control cells. …"
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592
PDX1<sup>−</sup>/NKX6.1<sup>+</sup> progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells
منشور في 2020"…Also, the 3D-beta cells secreted C-peptide in response to increased glucose concentrations indicating their functionality.…"
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593
Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
منشور في 2024"…Furthermore, induced pluripotent stem cell (iPSC) lines lacking RFX6 were generated using CRISPR/Cas9. …"