A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... حسب Abou-Ghazal, Mohamed

"…Long-term survival (>78 days) was observed in 80% of mice with established intracerebral syngeneic melanoma treated with 40 mg/kg of WP1066 in contrast to control mice who survived for a median of 15 days. Although WP1066 did not induce immunologic memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (transforming growth factor-β, RANTES, MCP-1, vascular endothelial growth factor), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The cost-benefit associated with the maturity of the Antimicrobial Stewardship Program versus prematurity in Heart Hospital of Hamad Medical Corporation in Qatar حسب Dina Abushanab (10696501)

"…With M-ASP, cost of hospital tests use ‘decreased’ by QAR 1,149 per 100-patient beds per year, cost of ASP personnel ‘decreased’ by QAR 125 per 100-patient beds with the M-ASP, cost of drug use ‘increased’ by QAR 176,848 per 100-patient beds, cost of resistance and hospitalization ‘increased’ by QAR 216,279 per 100-patient beds per year. …"

The impact of the activities of the Beirut port Free Zone on balance of trade, marine traffic and unemployment in Lebanon (1975-1984). (c1987) حسب Assaad, Jean Georges

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death حسب Tohme, Sara

"…This is followed by an increase in lipid peroxidation which peaks at later timepoints and varies between different cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Association of Differing Qatari Genotypes with Vitamin D Metabolites حسب Youssra Dakroury (9991407)

"…This may be of specific importance in vitamin D replacement strategies with the Q2 genotype requiring less, and the other genotypes requiring more to increase 1,25(OH)2D. Whilst overall the group was vitamin D deficient, total 25(OH)D was higher in diabetes, but 1,25(OH)2D, 24,25(OH)2D, and 3epi-25(OH)D were lower in diabetes that did not affect the relationship to genotype.…"

Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells حسب Shilpa Kuttikrishnan (3520079)

"…<p>Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. …"

Scalable Generation of Mesenchymal Stem Cells and Adipocytes from Human Pluripotent Stem Cells حسب Manale Karam (3619412)

"…Disruption of cell adhesion induced the subsequent differentiation of the highly expanded RA-derived EB-forming cells into a pure population of multipotent MSCs (up to 1542-fold increase in comparison to RA-untreated counterparts). …"

Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers حسب Husseini, Ghaleb

"…The folate receptor is widely expressed on the surface of several cell lines and tumors; including ovarian, brain, kidney, breast, and lung cancers. …"
احصل على النص الكامل

Theoretical Framework for Effective Communication Processes for the Agile Project Management Approach in the UAE Utility Sector حسب Afifi, Mutasim

احصل على النص الكامل
احصل على النص الكامل

Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018) حسب El Jawhari, Yassmine

"…Cytotoxicity of [HuArgI (Co)-PEG5000] was tested on two GBM cell lines, namely A172 and U251. Both cell lines showed increased sensitivity at longer incubation periods of [HuArgI (Co)-PEG5000] treatment with IC50 values in the pM range, a result attributable to the arginine auxotrophy expressed in those two cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Evaluation of pretreatment and membrane configuration for pressure-retarded osmosis application to produced water from the petroleum industry حسب Dareen Dardor (17052381)

"…PRO is typically considered with seawater/river water pairings however greater energy can be recovered from hypersaline solutions including produced water (PW) from the petroleum industry. …"

Graphite and metal nitrate-infused HDPE composites for enhanced thermal performance in energy-efficient building envelopes حسب Mohammad Amir Khan (23770803)

"…Analysis such as Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM), and dielectric spectroscopy analyses further revealed extensive interaction between filler matrices, a decrease in phonon scattering, and a positive increase in crystallinity which led to the improved thermal performance.The TGA results showed that the composite exhibited greater thermal stability, and the residue mass after the decomposition process was 9%, indicating increased carbonization and structural integrity. …"

Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury حسب Judith, Nwaiwu

"…Individuals with TBI have a greater risk of mortality from associated chronic diseases than the general population. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Giving anaemic cardiac surgery patients a better chance حسب Nature Research (16552612)

"…Anaemia commonly occurs as a result of cardiac surgery and has been repeatedly shown to increase patient illness and death.</p><p>Yet clinicians are not in agreement about the best time to treat anaemia with a blood transfusion. …"

Nano-aluminum حسب Doshi, Reeti

"…California red beans did not show uptake of aluminum, while the situation was different for rye grass where a 2.5-fold increase in Al concentration in the leaves was observed as compared with control tests. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The E-learning evolution education & business. (c2004) حسب Wahoud, Reem

"…Did it contain the right message, or give him/her the righ1skills? …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Creatine Kinase Is a Marker of Metabolic Syndrome in Qatari Women With and Without Polycystic Ovarian Syndrome حسب Noora Al-Hail (18140287)

"…CK correlated with BMI (p < 0.003) but not with waist/hip ratio. Overall, CK did not differ between PCOS and controls, rising equally in both as body mass index (BMI) increased. …"

Acoustically activated release of estrone-targeted liposomes used for breast cancer treatment حسب Mohammad, Najla

احصل على النص الكامل

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia... حسب Abi-Habib, Ralph J.

"…The activity of this toxin was then tested on a larger group of 13 human AML cell lines; 5 of the 13 cell lines were sensitive to DTU2GMCSF. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Total hip arthroplasty: Evolution of the use of dual mobility cups in Lebanon حسب Assi, Chahine

"…Recurrent dislocation, being a major reason for revision total hip arthroplasty (THA), was found to decrease significantly using dual mobility cup (DMC) compared to standard cups (SC), and that in both primary and revision THA. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل