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    A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

    Published 2008
    “…Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. …”
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  4. 424

    A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

    Published 2008
    “…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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  5. 425

    Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

    Published 2025
    “…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”
  6. 426

    Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

    Published 2023
    “…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”
  7. 427

    Inositol 1,4,5-Trisphosphate Receptors in Hypertension by Ali H. Eid (5461829)

    Published 2018
    “…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca<sup>2+</sup> signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP<sub>3</sub>R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”
  8. 428

    Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

    Published 2021
    “…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”
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    Seat belt and mobile phone use among young adult drivers in the State of Qatar by Sohaila Cheema (4162534)

    Published 2015
    “…Females were significantly more likely than males to use seat belt and less likely to use mobile phone while driving. Additionally, drivers at or below the age of 25 were significantly more likely to use seat belt and less likely to use mobile phone than those over 25 years old (Table 1). …”
  11. 431

    Anteriolateral versus anterior–posterior electrodes in external cardioversion of atrial fibrillation: A systematic review and meta‐analysis of clinical trials by Karam R. Motawea (13954362)

    Published 2023
    “…Subgroup analysis revealed a statistically significant association between the anterior–lateral electrode and increased cardioversion rate of AF in subgroups of less than five shocks, patients with 60 years old or more and patients with left atrial (LA) diameter >45 mm (OR = 1.72, 95% CI = 1.17–2.54, <i>p</i> = .006), (OR = 1.73, 95% CI = 1.18–2.54, <i>p</i> = .005), and (OR = 1.86, 95% CI = 1.04–3.34, p = .04), respectively. …”
  12. 432

    Teachers’ Job Satisfaction in Instructional Delivery Modalities, and the Role of School Leaders: a Study among Selected Private Schools in Abu Dhabi. by YAHYA, AHMAD

    Published 2022
    “…For example, the interviews recommended that school leaders are invited to build an active channel of communication with their teachers, share the decision-making process with them, decrease the workload, raise the teachers’ autonomy, and establish a remuneration system.…”
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  13. 433

    Speed optimised array architecture for flash EEPROMs by Amin, A.A.M.

    Published 1993
    “…The new array architecture provides increased speed and less susceptibility to soft writes during read operations. …”
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  14. 434

    Provision of spiritual care to advanced cancer patients by doctors and nurses in the Middle East by Bar_Sela, G.

    Published 2016
    “…When patients feel spiritually supported by staff, we find a higher QoL, increased use of hospice, and reduced use of aggressive treatments in EoL. …”
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    Industrial wastewater volume reduction through osmotic concentration: Membrane module selection and process modeling by Joel Minier-Matar (17052378)

    Published 2021
    “…However, both membranes showed less than 5% fouling and a specific forward organic solute flux of less than 0.5 mg/L of total organic carbon (TOC). …”
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    Machine Learning-Based Management of Electric Vehicles Charging: Towards Highly-Dispersed Fast Chargers by Mostafa Shibl (18810412)

    Published 2020
    “…The use of ML provides a less complex method to coordinate EVs, in comparison with conventional optimization techniques such as quadratic programming, and the use of ML is faster as it requires less computational power. …”
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    Ultrasound‑triggered herceptin liposomes for breast cancer therapy by Elamir, Amal

    Published 2021
    “…Exposing the liposomes to low-frequency ultrasound (LFUS) triggered drug release which increased with the increase in power density. Trastuzumab conjugation resulted in enhancing the sensitivity of the liposomes to LFUS. …”
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  20. 440

    Enablers and Barriers to Knowledge sharing in the UAE infrastructural projects by MOHAMED ALI AHMED, ALDHANHANI

    Published 2018
    “…The research outcomes indicate that three enablers influence the level of KS contributions to project success: the ability of social networks to simplify personal relationships and social interactions to facilitate the project KS process (E24); the characteristics of the physical environments such as the shape of the office spaces or relaxed and quiet environment (E30); and loyalty and hard work to increase project success via KS (E35). The research findings also show that four enablers are important for the benefits of timely KS in infrastructural projects: leadership commitment to support open and honest two-way communication in projects (E5), measurements of knowledge sharing before and after any project activities (E8), implementation of less formal resources such as social media to share embedded project knowledge (E11), and the ability to communicate between project stakeholders regarding the project through specific channels (E13). …”
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