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321
Snake venom in conjugation with silica nanoparticles: an emerging cancer therapy
Published 2025“…<i>In vitro</i> investigations on cancer cell lines revealed a considerable increase in cytotoxicity and induction of apoptosis as compared to free snake venom, with greater selectivity for malignant cells. …”
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322
PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
Published 2019“…PD-L1 promoter was significantly hypomethylated in MCF-7 tumorspheres, but not from BT-549 tumorspheres, compared with their cell line counterparts. The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”
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323
Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia
Published 2019“…Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID. …”
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324
Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways
Published 2018“…<p>With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. …”
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325
Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…Therefore, despite reported correlations between the obtained increases in chylomicron and VLDL plasma concentrations and atherogenesis, this study suggests that the reduced amount of cholesterol per newly secreted VLDL particle and their increased catabolic rate will ultimately lead to a reduced total and LDL cholesterol concentrations in the fasted state. …”
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326
Women’s empowerment as a determinant of neonatal mortality in Sub-Saharan Africa: a narrative review focused on Nigeria
Published 2024“…Notably, SSA and South Asia are the regions most lagging behind the Sustainable Development Goal (SDG) 3.2, aiming for <12 neonatal deaths per 1,000 live births by 2030. Within SSA, Nigeria, the most populous country, records the highest number of neonatal deaths annually. …”
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327
Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats
Published 2020“…Equally, it showed a rise of the apoptotic markers (a decrease in the expression of the Bcl-2 and an increase of the P53). …”
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328
Posterior microphthalmos and papillomacular fold-associated cystic changes misdiagnosed as cystoid macular edema following cataract extraction
Published 2015“…We report a case that underscores this scenario aiming to increase awareness of this entity among ophthalmologists. …”
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329
Students' Staying and Supportive Intentions at Federal Higher Education Institutions in the United Arab Emirates
Published 2022“…Furthermore, mediation analysis for the five antecedents of satisfaction on staying and supporting is a new contribution to the literature. …”
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330
The burden of prostate cancer in North Africa and Middle East, 1990–2019: Findings from the global burden of disease study
Published 2022“…The YLLs, YLDs, and DALYs of PCa increased by 2% (-11.8-23.1), 108% (75.5-155.1), and 6% (-8.9-28.1). …”
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331
Cost-Benefit Analysis of Antimicrobial Stewardship Program in the Adult General Medicine Setting in Qatar
Published 2024“…</p><h3> Results</h3><p dir="ltr">The operational costs of the program decreased with maturity by cost savings of QAR125 per 100-patient beds per year. …”
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332
Strengthening of reinforced concrete beams in flexure with side bonded CFRP laminates
Published 2017“…These deficiencies could be due to increase in loading, earthquake damage or even design and/or construction defects. …”
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333
Assessing the risk of angiotensin receptor blockers on major cardiovascular events: a systematic review and meta-analysis of randomized controlled trials
Published 2020“…</p><h3>Results</h3><p dir="ltr">Forty-five RCTs comprising of 170,794 participants were included in the analysis. …”
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334
Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans
Published 2024“…While surgical removal remains the conventional therapy with a 95% 5-year cure rate, there is a growing interest in exploring alternative treatment strategies. …”
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335
Unsustainability in emergent systems
Published 2017“…In this paper we present a detailed case study of the passenger road transport system in the Greater Beirut Area (GBA) where we identify the root causes of the major problems facing the system today and over the long-term. …”
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336
Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways
Published 2015“…Flow cytometric analysis indicated that both fractions induced sub-G1 phase accumulation and increased apoptotic cell death. Western blot revealed the activation of caspase-3, PARP cleavage, and a considerable increase in Bax and p53 levels, and a decrease in Bcl-2 level. …”
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337
Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex
Published 2019“…When compared to cisplatin, the photoproducts were more potent against all tested cell lines, implying that the complex acquired significant chemotherapeutic potential upon irradiation. …”
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338
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Published 2022“…<p>Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. …”
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339
Hydrophobic Ionic Liquids for Efficient Extraction of Oil from Produced Water
Published 2022“…The extraction efficiency was found to increase with increasing cation alkyl chain length from C2 to C10. …”
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340
The dissemination of antimicrobial resistance determinants in the environment through horizontal gene transfer. (c2019)
Published 2019“…Water samples were collected from El Qa’a refugee camp and five major rivers in Lebanon. All collected samples were diluted and inoculated on MacConkey agar. …”
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