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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
منشور في 2019"…PD-L1 promoter was significantly hypomethylated in MCF-7 tumorspheres, but not from BT-549 tumorspheres, compared with their cell line counterparts. The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …"
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Crisis Communication Management Model in the Public Sector of Dubai
منشور في 2012"…The use of CCM as a success factor for this effective crisis management enables the organization to avert or minimize the undesired impact on the businesses, stakeholders as well as the society. In a legendary city like Dubai, the fast growing businesses and the infrastructure developments as well as the population increase, any crisis type might be expected. …"
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Home Automation Awareness in United Arab Emirates
منشور في 2018"…With full awareness to invest in renewable and clean sources of energy and be less dependent on using nonrenewable sources of energy like fossil fuels and natural gas, moreover preserve water and natural resources. …"
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Effects of selenium in comparison to exendin-4 on the expression of GLP-1R, IRS-1 and preproinsulin in the pancreas of diabetic rats
منشور في 2016"…Results obtained indicate that GLP-1R and IRS-1 levels decreased while the level of preproinsulin mRNA increased in the pancreas of diabetic untreated rats, as compared to control rats. …"
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Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia
منشور في 2019"…Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID. …"
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Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways
منشور في 2018"…<p>With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. …"
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Arabic Question Answering: A Study on Challenges, Systems, and Techniques
منشور في 2019"…The enormous increase of the amount of information available on the web creates the need for systems like Question Answering to bridge the gap between general end users and the web with its different data representations. …"
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Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1
منشور في 2015"…PrAgU2/LF was cytotoxic to five out of nine AML cell lines. Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. …"
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THE USE OF AN OPEN CYCLE ABSORPTION SYSTEM IN AUTOMOBILES AS AN ALTERNATIVE TO CFCS
منشور في 2020"…Also, some suggestions are given to minimize the power loss like making use of the exhaust gas to pre-heat the weak desiccant. …"
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An Investigation into Teachers’ Perceptions Regarding Cyberbullying Policies and Practices in UAE Schools
منشور في 2023"…Inconsistent schools’ attempts to increase this awareness and spreading it through training, classroom activities and parental discussions were noticed. …"
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174
Unsustainability in emergent systems
منشور في 2017"…In this paper we present a detailed case study of the passenger road transport system in the Greater Beirut Area (GBA) where we identify the root causes of the major problems facing the system today and over the long-term. …"
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Parallel Algorithm for Hardware Implementation of Inverse Halftoning
منشور في 2005احصل على النص الكامل
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Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways
منشور في 2015"…Flow cytometric analysis indicated that both fractions induced sub-G1 phase accumulation and increased apoptotic cell death. Western blot revealed the activation of caspase-3, PARP cleavage, and a considerable increase in Bax and p53 levels, and a decrease in Bcl-2 level. …"
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Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex
منشور في 2019"…When compared to cisplatin, the photoproducts were more potent against all tested cell lines, implying that the complex acquired significant chemotherapeutic potential upon irradiation. …"
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