Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase by Marta Cecchi (21363581)

“…Moreover, dex stimulates spherogenesis of both cell lines, which is mediated by TDO, evident by its suppression with 680C91, a TDO inhibitor. …”

Evaluation of Estrone Liposomes using Microfluidics for Breast Cancer Therapy by Al Bostami, Rouba D.

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Electric Grid Resilience Enhancement During Natural Disasters: An Optimization-Based UAV Inspection and Dynamic Crew Dispatch Model by Serag, Yousef

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Effects of natural organic matter on aggregation kinetics of boron nanoparticles in monovalent and divalent electrolytes by Liu, Xuyang

“…However, the attachment efficiency kept increasing in the presence of CaCl2 and alginate with the increase in the electrolyte concentration and was greater than unity at >4 mM CaCl2. The destabilization was attributed to bridging of the nanoparticles by the alginate–Ca2+ system. …”
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Optimum sizing of steam turbines for concentrated solar power plants by Poullikkas, Andreas

“…Finally, although the cost of electricity of a CSP plant with capacities greater than 1MWe is significantly reduced to less than 1US$/kWh, currently such technology can only become economically viable through supporting schemes.…”
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Recovery of business intelligence systems by Haraty, Ramzi A.

“…Denial of service affects the continuity of the healthcare system which in turn threatens patients’ lives, decreases the efficiency of the healthcare system and increases the operating costs of the attacked healthcare organization. …”
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The impact of green supply chain management practices on environmental performance during COVID-19 period: the case of discretionary companies in the G-20 countries by El Khoury, Rim

“…It highlights the impact of green initiatives to cope with major disruptions and decrease pollution and environmental disaster.…”
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Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021 by Letourneau, Ian D

“…Although the global age-standardised incidence rate of appendicitis has steadily decreased between 1990 and 2021, almost half of GBD regions saw an increase of greater than 10% in their age-standardised incidence rates. …”
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A control algorithm to increase the efficient operation of wind energy conversion systems under extreme wind conditions by Nyam Jargalsaikhan (17380429)

“…<p dir="ltr">This paper aims to increase the power production of gearless permanent magnet synchronous generator (PMSG) based wind energy conversion systems (WECS) in strong (greater than 25 m/s) wind speed regions. In general, most wind turbines cut off when wind speed is over the cut-out rate; as a result, the power generation of the wind farm decreases. …”

A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. …”
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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Tumor protease-activated fusion toxins by Abi-Habib, Ralph J.

“…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”

Inositol 1,4,5-Trisphosphate Receptors in Hypertension by Ali H. Eid (5461829)

“…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca²⁺ signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

“…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”

Teachers’ Job Satisfaction in Instructional Delivery Modalities, and the Role of School Leaders: a Study among Selected Private Schools in Abu Dhabi. by YAHYA, AHMAD

“…For example, the interviews recommended that school leaders are invited to build an active channel of communication with their teachers, share the decision-making process with them, decrease the workload, raise the teachers’ autonomy, and establish a remuneration system.…”
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Coping mechanisms among Lebanese first-time college students by Doumit, Rita

“…As the usage of withdrawal coping strategies, being exposed to stress related to self and uncertainty increased, the well-being of Lebanese first-time college students decreased. …”
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Ultrasound‑triggered herceptin liposomes for breast cancer therapy by Elamir, Amal

“…Exposing the liposomes to low-frequency ultrasound (LFUS) triggered drug release which increased with the increase in power density. Trastuzumab conjugation resulted in enhancing the sensitivity of the liposomes to LFUS. …”
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Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment by Christos Fountoukis (4722963)

“…The model’s forecast accuracy was assessed against measurement data from five ground air quality monitoring stations in the greater metropolitan area of Doha over a one-month period. …”