Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells حسب Al Sayyed, Fatima

"…In this study, we investigate the efficacy of two small molecules Ruxolitinib, a JAK/STAT inhibitor, and CHIR-99021, a GSK-3 inhibitor, in targeting pediatric neuroblastoma stem cells by testing them on human MYC-N amplified, IMR-32, and non-MYC-N amplified, SK-N-SH, cell lines. Treating neuroblastoma cells with Ruxolitinib and CHIR-99021 resulted in significant reduction in cellular proliferation, viability, apoptosis and tumorsphere formation capacity in both IMR-32 and SK-N-SH cell lines. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Targeting potential arginine auxotrophy in glioblastoma (GBM) cells using human recombinant arginase I (CO)-PEG 5000 [HuArgl (Co)-PEG5000]. (c2013) حسب Khoury, Oula

احصل على النص الكامل
احصل على النص الكامل

Guidelines for the pharmacological treatment of peripheral neuropathic pain حسب Riachi, N.

"…The expert panel recommended pregabalin, gabapentin and secondary amine tricyclic antidepressants (nortriptyline and desipramine) as first-line treatments for peripheral NeP. Serotonin-norepinephrine reuptake inhibitor antidepressants, tramadol and controlled-release opioid analgesics were recommended as second-line treatments. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The July war and its effects on Lebanon’s power-sharing حسب Fakhoury, Tamirace

"…On a broader scale, this article helps shed light on the dilemma of power-sharing systems on stormy seas when external conflicts overlap with internal conflict lines.…"
احصل على النص الكامل

The Impact of Fostering Parasocial Relationship Between Influencing Entrepreneurs and Social Media Followers on the Brand Image and the Purchase Intentions of Start-Up Companies حسب Awawdeh, Esraa

احصل على النص الكامل
احصل على النص الكامل

Effectiveness of communication processes in Agile Project Management Approach in the UAE Utility Sector حسب AFIFI, MUTASIM ABDALLA HASSAN

"…Team members should have a voice in the agile project management process, maintain open lines of communication with stakeholders, and discuss problems in a timely manner to increase tolerance and acceptance.…"
احصل على النص الكامل

Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance حسب Zouhaier Farhani (22330693)

"…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…"

Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes حسب Rizk, Sandra

"…The percent reduction in proliferation was very significant, and was dose-, and time-dependent. In both cell lines, kefir exhibited its antiproliferative effect by downregulating TGF-α and upregulating TGF-β1 mRNA expression. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Anticancer and antioxidant effects of tragopogon porrifolius extract. (c2011) حسب Tenkerian, Clara A.

احصل على النص الكامل
احصل على النص الكامل

Phenotypic and Proteomic characterization of Clinical Candida albicans isolates resistant to Fluconazole حسب Geukgeuzian, Giovanni

"…The azole fluconazole is the first line of defense in hospital treatment. Azoles function by inhibiting Erg11 an enzyme involved in the synthesis of ergosterol, the main sterol found in fungi. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Organizational Strategy and Employee Productivity in Oil and Gas Industry: The Case of the United Arab Emirates حسب Al-Ansari, Haima Ali Al-Mulla

"…Owing to the advent of globalization, there is an increasing demand for improved productivity and increased efficiency from employees. …"
احصل على النص الكامل

The Activation Kinetics and Crosstalk of RhoGTPases حسب Al Haddad, Maria

"…Using this technique, we are studying the crosstalk of Rho GTPases in different cell lines, with a focus on RhoA, RhoC, Cdc42 and Rac1. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Targeting acute myeloid leukemia cells with novel photosensitive ruthenium-based metal-organic compounds. (c2015) حسب Azar, Daniel Fadi

"…Furthermore, we have attempted to examine the photochemical potential of our metal-organic compound model by combining L-II and L-III in the same metal complex, thus generating four final complexes with differing net charges (from +2 to -4), and examining their activities on a panel of AML cell lines with or without exposure to blue light. Of the four final complexes Ru-II3, Ru-II2-III, Ru-II-III2 and Ru-III3, only Ru-II3 and Ru-II2-III have shown significant activity against all tested cell lines in the dark, whereas photo-activation against ML2 has shown a marked increase of potency of all four complexes, even those shown to be biologically inert in the dark, reaching IC50 values in the nM range. …"
احصل على النص الكامل
احصل على النص الكامل

Using Nearpod to Promote Engagement in Online ESL Classes: A Mixed-Methods Study in the Context of Higher Education حسب Alawadhi, Azza

احصل على النص الكامل

Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells حسب Tawil, Mirna

"…In this study, we used Daucus carota oil extract (DCOE) to target acute myeloid leukemia (AML) cells. All the AML cell lines tested were sensitive to the extract while peripheral mononuclear cells were not. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Colloid retention and mobilization mechanisms under different physicochemical conditions in porous media: A micromodel study حسب Safna Nishad (16932474)

"…However, hydrophilic colloids redeposited on gas-water-solid interfaces or thin water films because of their greater capillary potential. Therefore, greater filtration efficiency is achieved with the hydrophilic colloids compared to the hydrophobic colloids for which the efficiency can be improved by changing the solution chemistry. …"

Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute... حسب Farhat, Mirna

"…However, given that MMP9 was found not to be expressed in the sensitive cell lines, we were able to exclude its expression as a requirement for cytotoxicity. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells حسب Bekdash, Amira

"…In this study, we target arginine auxotrophy of AML cell lines using human arginase I cobalt-PEG5000. HuArgI(Co)-PEG5000 was cytotoxic to all AML cell lines tested. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Investigation of an integrated hydrogen production system based on nuclear and renewable energy sources: a new approach for sustainable hydrogen production via copper–chlorine ther... حسب Orhan, Mehmet Fatih

"…Hydrogen production via thermochemical water decomposition is a potential process for direct utilization of nuclear thermal energy to increase efficiency and thereby facilitate energy savings. …"
احصل على النص الكامل

The Anti-Tumor Effect of Flaxseed Lignan Derivatives on Different Acute Myeloid Leukemia Cancer Cells حسب Tannous, Stephanie

"…Cytotoxicity assays, using WST-1, revealed dose- and time- dependent effects in various AML cell lines with the most prominent cytotoxicity exhibited by ENL. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل