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Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)
منشور في 2004"…Interestingly, we have recently observed an increase in hepatocyte apoptosis with administration of TPN. …"
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Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase
منشور في 2022"…Moreover, dex stimulates spherogenesis of both cell lines, which is mediated by TDO, evident by its suppression with 680C91, a TDO inhibitor. …"
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Targeting Breast Cancer Using Hyaluronic Acid-Conjugated Liposomes Triggered with Ultrasound
منشور في 2021"…HA conjugation to the liposomes resulted in a significant increase in calcein uptake by the breast cancer cell line MDA-MB-231 known for its CD44 (HA receptor) overexpression, while such an effect was not recorded with NIH-3T3, an embryonic mouse fibroblast, with low levels of CD44 expression. …"
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Insertion Mutation in Tnfrsf11a Causes a Paget's Disease–Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice
منشور في 2021"…Mice heterozygous for the mutation (Tnfrsf11a<sup>75dup27/−</sup>) developed a PDB-like disorder with focal osteolytic lesions in the hind limbs with increasing age. …"
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Novel proteins implicated in lipid metabolism disorders
منشور في 2016"…</p><p>ANGPTL3 is a protein secreted by the liver, belonging to the angiopoietin-like family of eight proteins. …"
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Performance analysis of power line communication systems with diversity combining under correlated lognormal fading and Nakagami noise
منشور في 2017"…In this study, the authors evaluate the bit error rate (BER) performance of multichannel power line communication (PLC) systems under lognormal fading and Nakagami-m background noise. …"
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Efficacy and safety of aldafermin in non-alcoholic steatohepatitis: A systematic review and meta-analysis of randomized controlled trials
منشور في 2024"…<h3>Background</h3><p dir="ltr">Non-alcoholic steatohepatitis (NASH) is an advanced subtype of non-alcoholic fatty liver disease (NAFLD). NASH prevalence is increasing exponentially and carries a high risk for disease progression, cirrhosis, and liver-related mortality. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…Methods and results Using the WST assay, the pentane fraction (F1) and 1:1 pentane:diethyl ether fraction (F2) were shown to possess the highest cytotoxicity against both cell lines. Flow cytometric analysis revealed that both fractions induced the accumulation of cells in the sub-G1 phase, increase in apoptotic cell death and chromatin condensation. …"
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The anti-cancer effect of the pentane fraction of Daucus carota oil extract is mediated through cell cycle arrest and an increase in apoptosis
منشور في 2013"…Previous studies from our laboratory demonstrated the in vitro anticancer activities of Daucus carota oil extract (DCOE) on colon and breast human cancer cell lines. In the current study, we aimed at fractionating the Daucus carota oil extract (DCOE) and analyzing the in vitro anticancer activities of the obtained fractions. …"
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Dextran Sodium Sulfate-Induced Impairment of Protein Trafficking and Alterations in Membrane Composition in Intestinal Caco-2 Cell Line
منشور في 2020"…The present study investigates endoplasmic reticulum (ER) stress in addition to alterations in protein and membrane trafficking in a dextran sulfate sodium (DSS)-induced IBD-like phenotype of intestinal Caco-2 cells in culture. …"
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Papillary Thyroid Carcinoma with Fibromatosis/Fasciitis-Like/Desmoid-Type Stroma: Case Report of a Rare Subtype with Cytological and Molecular Study
منشور في 2024"…<h3>Background</h3><p dir="ltr">Papillary thyroid carcinoma (PTC) with fibromatosis/fasciitis-like/desmoid-type stroma is a rare subtype of PTC,characterized by two distinct components: a classic papillary carcinoma component and a spindle cell proliferationresembling fibromatosis or nodular fasciitis. …"
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Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
منشور في 2021"…</p><h3>Conclusion</h3><p dir="ltr">Hypoglycemia potentiated both plasma sNRP1 level elevation and its ligands VEGF and SEMA3A, likely through an ADAM9-mediated mechanism that was not associated with RAS overactivity or ACEi therapy; however, whether this is protective or promotes increased risk for SARS-CoV-2 infection in T2D is unclear.…"
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Lipophilic Metabolites and Anatomical Acclimatization of Cleome amblyocarpa in the Drought and Extra-Water Areas of the Arid Desert of UAE
منشور في 2019"…The plant showed the presence of shaggy-like trichomes. The plant also developed special mechanisms to ensure its survival via release of lipophilic metabolites. …"
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The impact of size on particle drainage dynamics and antibody response
منشور في 2021"…The size and the repetitive geometric shape of virus-like particles (VLPs) influence their immunogenicity by facilitating drainage to secondary lymphoid organs and enhancing interaction with and activation of B cells and innate humoral immune components. …"
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Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet
منشور في 2011"…Non-alcoholic fatty liver disease (NAFLD) is one of the commonest liver diseases in Western countries. …"
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Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: Results of a multicenter study
منشور في 2004"…Of these, 53 (43%) died of recurrence, 30 (24%) of post-operative complications, and 40 (33%) of liver failure/hemorrhage. On multivariateanalysis, tumor size greater than 5 cm (P < 0.02; odds ratio, 3.0), multiple tumors(P < 0.01; odds ratio, 3.3), and greater than 5 mitoses per 10 high-power fields(P < 0.03; odds ratio, 3) were associated with increased risk of early death due torecurrence.Conclusions: These findings enable identification of patients with HCC who are athigh risk for early death due to recurrence following potentially curative resection whomight be candidates for adjuvant therapy trials.…"
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
منشور في 2019"…Altogether our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. …"
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