PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications by Pramod Darvin (153341)

“…PD-L1 promoter was significantly hypomethylated in MCF-7 tumorspheres, but not from BT-549 tumorspheres, compared with their cell line counterparts. The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”

Effects of selenium in comparison to exendin-4 on the expression of GLP-1R, IRS-1 and preproinsulin in the pancreas of diabetic rats by Rizk, Sandra

“…Results obtained indicate that GLP-1R and IRS-1 levels decreased while the level of preproinsulin mRNA increased in the pancreas of diabetic untreated rats, as compared to control rats. …”
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The Impact of Interprofessional Immersive Simulation-Based Education on Learning Outcomes and Perceived Competence and Practice in Specialty and Sub-specialty Critical Care Courses by Mona Farah (18466432)

“…There are critical situations and emergencies where immediate reactions or interventions are essential to save patients’ lives. High levels of critical care workload and complexity can increase the likelihood of mistakes and practice errors. …”

Optimizing emergency services in hospitals by Nature Research (16552612)

“…Timely treatment can save lives, but sometimes cannot be delivered owing to a lack of sufficient resources, particularly beds and qualified healthcare professionals. …”

Partnering for Sustainability: Parent-Teacher-School (PTS) Interactions in the Qatar Education System by Maryam A. Al-Hail (18595765)

“…<div><p>The interaction avenues, levels, and impacts between parents, schools and teachers have changed drastically due to the ever-increasing responsibilities, frequent and rapid changes in the curriculum, the invasive dominance of the internet and digital media in the lives of all stakeholders, and the digitization of learning materials, to name a few. …”

Stabilization of Sandy Soil Against Internal Erosion Using Lime by Banu, Shaziya Ahmed

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Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia by Shilpa Kuttikrishnan (3520079)

“…Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID. …”

Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways by Khaled W. Sadek (14153196)

“…<p>With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. …”

Arabic Question Answering: A Study on Challenges, Systems, and Techniques by Samy, Heba

“…The enormous increase of the amount of information available on the web creates the need for systems like Question Answering to bridge the gap between general end users and the web with its different data representations. …”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002) by Berberi, Rania

“…Therefore, despite reported correlations between the obtained increases in chylomicron and VLDL plasma concentrations and atherogenesis, this study suggests that the reduced amount of cholesterol per newly secreted VLDL particle and their increased catabolic rate will ultimately lead to a reduced total and LDL cholesterol concentrations in the fasted state. …”
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The protective role of lidocaine in surgeries involving trigeminal nerve manipulation: a meta-analysis of trigeminocardiac reflex prevention by Almonzer Al-Qiami (22393303)

“…This leads to a rapid increase in parasympathetic activity, resulting in a decrease in heart rate (HR) and blood pressure, which can potentially lead to bradycardia, and cardiac arrest, with a prevalence of 14.5% during neurointerventional procedures (8). …”

Ambulatory general urgent clinic: an initiative at the time of COVID-19 pandemic by Abdullah Al-Hothi (18505290)

“…Our quality improvement study aimed to decrease the waiting time by 20%, from 21 days in January 2021 to 14 days in April 2021, to evaluate the newly established clinics for urgent referrals during the COVID-19 pandemic, and to assess the physicians’ satisfaction regarding these clinics.…”

Women’s empowerment as a determinant of neonatal mortality in Sub-Saharan Africa: a narrative review focused on Nigeria by Joel-Medewase Victor Idowu (22155178)

“…Notably, SSA and South Asia are the regions most lagging behind the Sustainable Development Goal (SDG) 3.2, aiming for <12 neonatal deaths per 1,000 live births by 2030. Within SSA, Nigeria, the most populous country, records the highest number of neonatal deaths annually. …”

Comparative Study on Beneficial Effects of Hydroxytyrosol- and Oleuropein-Rich Olive Leaf Extracts on High-Fat Diet-Induced Lipid Metabolism Disturbance and Liver Injury in Rats by Ines Fki (14571855)

“…Equally, it showed a rise of the apoptotic markers (a decrease in the expression of the Bcl-2 and an increase of the P53). …”

The burden of prostate cancer in North Africa and Middle East, 1990–2019: Findings from the global burden of disease study by Mohsen Abbasi-Kangevari (9714440)

“…</p><h3>Results</h3><p dir="ltr">The age-standardized rates (95% UI) of PCa incidence, prevalence, and death in 2019 were 23.7 (18.5-27.9), 161.1 (126.6-187.6), and 11.7 (9.4-13.9) per 100,000 population. While PCa incidence and prevalence increased by 77% and 144% during 1990-2019, respectively, the death rate stagnated. …”

Cost-Benefit Analysis of Antimicrobial Stewardship Program in the Adult General Medicine Setting in Qatar by Dina Abushanab (10696501)

“…</p><h3> Results</h3><p dir="ltr">The operational costs of the program decreased with maturity by cost savings of QAR125 per 100-patient beds per year. …”

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 by Nasser, Selim

“…PrAgU2/LF was cytotoxic to five out of nine AML cell lines. Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. …”
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THE USE OF AN OPEN CYCLE ABSORPTION SYSTEM IN AUTOMOBILES AS AN ALTERNATIVE TO CFCS by Al-Aqeeli, N.

“…Also, some suggestions are given to minimize the power loss like making use of the exhaust gas to pre-heat the weak desiccant. …”
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An Investigation into Teachers’ Perceptions Regarding Cyberbullying Policies and Practices in UAE Schools by Hamad, Hanan Ahmad

“…Inconsistent schools’ attempts to increase this awareness and spreading it through training, classroom activities and parental discussions were noticed. …”
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Unsustainability in emergent systems by Haddad, Marc

“…In this paper we present a detailed case study of the passenger road transport system in the Greater Beirut Area (GBA) where we identify the root causes of the major problems facing the system today and over the long-term. …”
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