A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. …”
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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Tumor protease-activated fusion toxins by Abi-Habib, Ralph J.

“…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”

Inositol 1,4,5-Trisphosphate Receptors in Hypertension by Ali H. Eid (5461829)

“…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca²⁺ signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

“…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”

Solar syngas production via methanothermal reduction of strontium oxide by Rahul R. Bhosale (6467102)

“…Application of heat recuperation considerably decreased the requirement of solar energy input, and hence the process efficiency is further amplified. …”

Potent anti-tumor promoting effects of Daucus carota oil extract in mice by Abou Zeinab, RM

“…Inraperitoneal treatment inhibited tumor yield by 43%, and decreased the tumor volume by 85% at week 20. Gavage treatment failed to inhibit the promotion of tumors but decreased tumor volume by 20%. …”
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The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B... by Saeid Safiri (3713035)

“…Globally, colorectal cancer accounted for 896 000 (876 300–915 700) deaths in 2017, with an age-standardised death rate of 11·5 (11·3–11·8) per 100 000 person-years, which decreased between 1990 and 2017 (−13·5% [–18·4 to −10·0]). …”

Ultrasound‑triggered herceptin liposomes for breast cancer therapy by Elamir, Amal

“…Exposing the liposomes to low-frequency ultrasound (LFUS) triggered drug release which increased with the increase in power density. Trastuzumab conjugation resulted in enhancing the sensitivity of the liposomes to LFUS. …”
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Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment by Christos Fountoukis (4722963)

“…The model’s forecast accuracy was assessed against measurement data from five ground air quality monitoring stations in the greater metropolitan area of Doha over a one-month period. …”

The Effects of Online Formative and Summative Assessment on Test Anxiety and Performance: A Study Among First-Year Undergraduate Students at A Higher Education Institution in Abu D... by ALSUWAIDI, MUNA

“…The presented study was conducted to provide greater insight into the potential positive, neutral and/or negative effects of online formative and summative assessment on test anxiety and performance. …”
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Impact of inter-relay cooperation on the performance of FSO systems with any number of relays. (c2015) by Noun, Zeina K.

“…Finally, chapter five summarizes this work and the gives some insights as to how we can further develop and ameliorate the FSO systems.…”
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Strengthening of reinforced concrete beams in shear using different steel reinforced grout techniques by Tadesse G. Wakjira (14779165)

“…The average increase in the shear strength of the EB-SRG strengthened beam was 54% and 105% for the continuous and discontinuous SRG strips, respectively. …”

Composite hydrogels from carrageenan-cl-carboxymethyl chitosan–PVA incorporated ZiF-8 as dressing material for wound healing applications by Tooba Yasin (19131382)

“…The biocompatibility of the composite hydrogels has been evaluated using fibroblast cell lines (<i>3T3</i>) after different time intervals (24–72 h), and it was found that increasing ZiF-8 caused the mature and spread cell morphology with increasing cell viability and proliferation under controlled in vitro conditions. …”

The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis by Arwa Aldaalis (13355328)

“…Consequently, inactivation of SREBP1 in human liver and breast cancer cell lines reduces the expression of cyclin D1 and attenuates Rb phosphorylation. …”

Optimizing microgrid efficiency: Coordinating commercial and residential demand patterns with shared battery energy storage by Mohammadreza Gholami (17032317)

“…In response to the increasing integration of BESS in modern energy systems, this study investigates the implications of incorporating BESS within connected residential-commercial Microgrids (MGs). …”

Developing a Hybrid Model for Network Planning in Abu Dhabi Distribution Company Subsidiary of Adwea by Al Haddabi, Aseya Mohammed

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Effect of nickel loading on hydrogen production and chemical oxygen demand (COD) destruction from glucose oxidation and gasification in supercritical water by Youssef, Emhemmed A.

“…Results also showed that the presence of Ni increased the total gas yield increased in the 7.5–18 wt Ni/Al2O3 catalyst. …”
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