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341
Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors
Published 2011“…We sought to identify gastrointestinal neuroendocrine CSCs (N-CSCs) in surgical specimens and a NET cell line and to characterize novel N-CSC therapeutic targets. …”
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342
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Published 2023“…Our study investigated NSP‐B's antitumor effects on MM cell lines (U266 and RPMI8226) and the involved molecular mechanisms. …”
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343
Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells <i>via</i> Tryptophan 2,3 Dioxygenase
Published 2022“…Moreover, dex stimulates spherogenesis of both cell lines, which is mediated by TDO, evident by its suppression with 680C91, a TDO inhibitor. …”
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344
Evaluation of Estrone Liposomes using Microfluidics for Breast Cancer Therapy
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345
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346
Effects of natural organic matter on aggregation kinetics of boron nanoparticles in monovalent and divalent electrolytes
Published 2010“…However, the attachment efficiency kept increasing in the presence of CaCl2 and alginate with the increase in the electrolyte concentration and was greater than unity at >4 mM CaCl2. The destabilization was attributed to bridging of the nanoparticles by the alginate–Ca2+ system. …”
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347
Optimum sizing of steam turbines for concentrated solar power plants
Published 2012“…Finally, although the cost of electricity of a CSP plant with capacities greater than 1MWe is significantly reduced to less than 1US$/kWh, currently such technology can only become economically viable through supporting schemes.…”
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348
The impact of green supply chain management practices on environmental performance during COVID-19 period: the case of discretionary companies in the G-20 countries
Published 2022“…It highlights the impact of green initiatives to cope with major disruptions and decrease pollution and environmental disaster.…”
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349
A control algorithm to increase the efficient operation of wind energy conversion systems under extreme wind conditions
Published 2022“…<p dir="ltr">This paper aims to increase the power production of gearless permanent magnet synchronous generator (PMSG) based wind energy conversion systems (WECS) in strong (greater than 25 m/s) wind speed regions. In general, most wind turbines cut off when wind speed is over the cut-out rate; as a result, the power generation of the wind farm decreases. …”
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350
Outcome of home parenteral nutrition in 251 children over a 14-y period
Published 2016“…An increased rate of CRBSIs was observed compared with our previous study, but we saw a decreasing trend since 2012. …”
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351
A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells
Published 2008“…Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. …”
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352
A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce...
Published 2008“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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353
Tumor protease-activated fusion toxins
Published 2003“…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …”
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354
Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation
Published 2025“…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”
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355
Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
Published 2023“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”
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356
Inositol 1,4,5-Trisphosphate Receptors in Hypertension
Published 2018“…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca<sup>2+</sup> signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP<sub>3</sub>R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”
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357
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
Published 2021“…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”
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358
Teachers’ Job Satisfaction in Instructional Delivery Modalities, and the Role of School Leaders: a Study among Selected Private Schools in Abu Dhabi.
Published 2022“…For example, the interviews recommended that school leaders are invited to build an active channel of communication with their teachers, share the decision-making process with them, decrease the workload, raise the teachers’ autonomy, and establish a remuneration system.…”
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359
Emergency ultrasound training needs review
Published 2017“…Residents’ level of confidence also increased with increased years of experience for all types of sonography except for scanning first trimester pregnancies. …”
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360