Dual Targeting of Matrix Metalloproteases and the MAPK Pathway in Acute Myeloid Leukemia Cells Using an MMP-activated anthrax lethal toxin (PrAgL1/LF) حسب Al Saneh, Ahmad

"…Inhibition of the MAPK pathway through PrAgL1/LF led to sustained activation of autophagy, starting at 24 hours and lasting up to 120 hours following treatment with PrAgL1/LF in the AML cell lines. Addition of CQ led to an increase in cell cytotoxicity following treatment with PrAgL1/LF, at all time points, indicating that the inhibition of the MAPK pathway in AML cells leads to the activation of autophagy, which in turn mediates cell death following treatment with PrAgL1/LF. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Growth hormone treatment modulates active ghrelin levels in rats حسب Haddad, Haytham

"…Consequently, under such treatment, determination of active ghrelin concentration per tissue mass rather than per tissue protein is favored. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Performance assessment of an integrated absorption cooling-hydrogen liquefaction system using geothermal energy حسب Gadalla, Mohamed

"…The results show that the mass of hydrogen gas pre-cooled by the absorption system per unit mass flow rate of geothermal water flowing through the system (n) and the amount of hydrogen liquefied per unit mass flow rate of geothermal water flowing through the system (y) increase with an increase in the geothermal source temperature. …"
احصل على النص الكامل

A comprehensive design and rating study of evaporative coolers and condensers. Part II. Sensitivity analysis حسب QURESHI, BILAL AHMED

"…For evaporative condenser design, it was seen that, for a 53% increase in the inlet relative humidity, the normalized sensitivity of the surface area increased 1.8 times in value and, for a 15 8C increase in the condenser temperature, the sensitivity increased by 3.5 times. …"
احصل على النص الكامل

An improved non-dimensional model of wet-cooling towers حسب QURESHI, BILAL AHMED

"…The first method shows a maximum decrease of 4.4 per cent in error, whereas in the second method, the maximum error was found to be 3.3 and 6.8 per cent when the inlet air was unsaturated and saturated, respectively. …"
احصل على النص الكامل

Water Footprint Assessment and Virtual Water Trade in the Globally Most Water-Stressed Country, Qatar حسب Nayla Higazy (17679453)

"…<p dir="ltr">Qatar is one of the most water stressed countries globally, despite Qatar’s aridity and its lack of freshwater resources, per capita water consumption became one of the highest in the world due to population growth, agricultural expansion, rapid urbanization and industrialization and it is expected to increase in the coming decades. …"

PSA-activated proaerolysin as a prostate specific cancer therapy حسب Abi-Habib, Ralph

"…Activity toward proaerolysin was decreased 10-100 fold for each of the proteases tested except PSA, which showed a 4-fold increase in activity against the modified protein. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Annona cherimola Seed Extract Activates Extrinsic and Intrinsic Apoptotic Pathways in Leukemic Cells حسب Haykal, Tony

"…Treatment with an A. cherimola seed ethanolic extract promotes a dose- and time-dependent inhibition of the proliferation of various AML cell lines, but not MSCs. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Annona cherimola Seed Extract Activates Extrinsic and Intrinsic Apoptotic Pathways in Leukemic Cells By Peter Nasr A thesis حسب Nasr, Peter

"…Treatment with an A. cherimola seed ethanolic extract promotes a dose- and time-dependent inhibition of the proliferation of various AML cell lines, but not MSCs. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Malva pseudolavatera Leaf Extract Promotes ROS Induction Leading to Apoptosis in Acute Myeloid Leukemia Cells In Vitro حسب El Khoury, Marianne

"…Treatment of AML cell lines with M. pseudolavatera methanolic leaf extract showed a dose- and time-dependent inhibition of proliferation and a dose-dependent increase in apoptotic hallmarks such as an increase in phosphatidylserine on the outer membrane leaflet and membrane leakage in addition to DNA fragmentation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effects of short term genotropin (rgGH) subcutaneous injection on active ghrelin concentration in rat plasma, stomach, kidney & pancreas. (c2007) حسب Haddad, Haytham

احصل على النص الكامل
احصل على النص الكامل

Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex حسب Mehanna, Stephanie

"…Complex 2 exhibited 35 times lower cellular concentration relative to complex 1. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021 حسب Letourneau, Ian D

"…Although the global age-standardised incidence rate of appendicitis has steadily decreased between 1990 and 2021, almost half of GBD regions saw an increase of greater than 10% in their age-standardised incidence rates. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The antioxidant and anticancer effects of Wild Carrot oil extract حسب Shebaby, Wassim Nasri

"…The effect of DCOE on the cell lines exhibited time and dose-dependent responses. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The Global Economic crisis & organisation change: case studies in the UAE حسب Al Hashemi, Khalid

"…All of these elements should tie together in order to assure the existence of the company as a main target & then the expansion of the operation which means an increase in the profit. …"
احصل على النص الكامل

Organizational Change Management: A study on the need for a re-structured organization within a functional configuration حسب Al Marzouqi, Abdulla Ibrahim Abdulla

"…Then, critical factors that might lead to choosing one form of structure over the others will be discussed by deciding about how to tie projects to the parent organization and how to organize the project teams. …"
احصل على النص الكامل

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes حسب Maryam Aghadi (17128819)

"…Here, we used FOXA2−/−iPSC lines to understand the role of FOXA2 on the development and function of human hepatocytes. …"

Targeting human acute myeloid leukemia cells using human recombinant arginase I (Co) - PEG5000 [HuArgl (Co) - PEG5000] - induced arginine depletion. (c2013) حسب Tanios, Rita Farid

احصل على النص الكامل
احصل على النص الكامل

Minimization of the amplitude of the entire span of beams using mass dampers حسب Issa, Jimmy S.

"…Since minimizing the amplitude at one point of the beam might increase it at another point, in this work the maximum amplitude along the entire beam span is minimized. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Agent Based Modeling to Optimize Supermarkets Spatial Dimensions حسب NASIF, MAJD

"…It is the situation where the shoppers feel that the supermarket is overloaded with people at certain times. We solved this problem by providing an optimal area range for the supermarket where we reduced the crowding levels dramatically, while avoiding unnecessary increase in space dimensions. …"
احصل على النص الكامل