A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…Gaussian accelerated molecular dynamics (GaMD) simulations of the predicted alpha-helical synthetic Mpro cleavage sequences revealed a dynamic nature of the cleavage sequences, which is critical for their efficient cleavage, and a relatively short end-to-end distances, which is required for high BRET. Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …”
Get full text
Get full text
Get full text

Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells by Shebaby, Wassim N.

“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
Get full text
Get full text
Get full text

Increased Frequency of Severe Hypoglycemia with the Modified-Release Gliclazide Compared to Glimepiride in Diabetic Older Adults; Propensity Score-Adjusted Analysis by Ahmed Fouad Algendy (18102706)

“…The low doses of both treatments did not show any SHEA cases, while the results with higher doses showed the same pattern of increased risk with gliclazide MR as the principle analysis. …”

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection? by Abu Saleh Md Moin (6189512)

“…Baseline sNRP1, VEGF and ADAM9 did not differ between T2D and controls and remained unchanged in response to hypoglycaemia. …”

Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases by Kishi, Yoji

“…Results Treatment consisting of ≥9 cycles was not associated with an increase in complete or major pathologic response (SD vs. …”
Get full text
Get full text
Get full text

Bound by barriers: demystifying the constraints on an elevated Kuwait-Türkiye co-operation in the defence realm by Ali Bakir (17917703)

“…First, Kuwait is less inclined to enhance its security and defence ties with Türkiye compared to the UAE, Qatar, and Saudi Arabia. …”

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 by Jonathan M. Kocarnik (7512677)

“…The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. …”

Three-way decision-based conditional probabilities by opinion scores and Bayesian rules in circular-Pythagorean fuzzy sets for developing sustainable smart living framework by A. Alsattar, Hassan

“…Sustainable smart living (SSL) is a crucial component in the emergence of smart cities. …”
Get full text
Get full text

Effect of Girder Damage on the Structural Behavior of Slab-on-Girder Bridges by Elozn, Ahmed E.

Get full text

Living Materials: Preserving Student Innovation in Art and Science through Digital Twins and AI in Partnership with Qatar National Library : What Happens To Your Work After You Gra... by Arif Shaon (13761784)

“…The presentation also situates student work within a broader global research ecosystem, emphasizing citability, verification, and long-term impact in an era increasingly shaped by AI-generated content.</p><p dir="ltr">This resource is intended for students, educators, librarians, and institutions interested in sustainable models for preserving student innovation, practice-led research, and interdisciplinary creative outputs.…”

Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019 by Razieh, Hassannejad

“…MethodsWe used the 2019 Global Burden of Disease (GBD) data for estimates of prevalence, years lived with disability (YLDs), and underlying causes of HF in the EMR. …”
Get full text
Get full text
Get full text

Percutaneous coronary intervention can be safely performed with left ventricular thrombus without increasing stroke risk: A 5-year retrospective review using real-world data by Mohanad Shehadeh (17860691)

“…Similarly, in-hospital mortality, all-cause mortality, and stroke at 12 months did not differ between the study groups.</p><h3>Conclusion</h3><p dir="ltr">Performing CAG +/− PCI among patients with LVT was not associated with an increased risk of stroke during admission or within 12 months in comparison to patients who did not undergo CAG +/− PCI, which may reassure cardiologists to perform CAG +/− PCI among patients with LVT safely.…”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Alize J, Ferrari

“…However, despite this overall increase, HALE decreased by 2·2% (1·6–2·9) between 2019 and 2021. …”
Get full text
Get full text
Get full text

Experimental Investigation of FRP-Reinforced Concrete Columns Under Concentric and Eccentric Loading by Elmesalami, Nouran Zinelabdin Ahmed

Get full text

Performance evaluation of various growing media in vertical green wall for greywater treatment in hyper-arid climate by Jasir Jawad (17191468)

Active Botanical Biofiltration in Built Environment to Maintain Indoor Air Quality by Mehzabeen Mannan (16442001)

Surgical Management of Hepatic Benign Disease: Have the Number of Liver Resections Increased in the Era of Minimally Invasive Approach? Analysis from the I Go MILS (Italian Group o... by Ardito, Francesco

“…Although an evident growth of the use of MILS was observed during the time period analysis in Italy, this trend did not correspond to an increased number of MILS for BD, and the overall rate of resected BD was comparable to that reported in previous large open series.…”
Get full text
Get full text
Get full text
Get full text

Five-Level MLI-Based Grid-Connected Photovoltaic Systems: A Review on Control Methodologies, Modulation Strategies and Recent Developments by Anurag Tiwari (3563561)

A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor by Anupriya M. Geethakumari (17052375)

“…Co-expression of the sensors with M^pro in live cells resulted in their cleavage while mutation of the critical C145 residue (C145A) in M^pro completely abrogated their cleavage. …”

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 20... by Sudabeh Alatab (11257335)

“…The age-standardised prevalence rate increased from 79·5 (75·9–83·5) per 100 000 population in 1990 to 84·3 (79·2–89·9) per 100 000 population in 2017. …”