Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway حسب Yanqing, Li

"…Chronic itch is a common and complex symptom often associated with skin diseases such as atopic dermatitis (AD). Although IL-27 is linked to AD, its role and clinical significance in itch remain undefined. …"
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Genome-Based Characterization of Bacterial Pathogens Causing Bloodstream Infection حسب Boujanian, Carni

"…Carbapenem resistance and ESBLs were linked to several factors, including variants of NDM such as blaNDM-5 (3/24) and blaNDM-1 (3/24), variants of OXA including blaOXA-1 (9/24) and blaOXA-48 (2/24), and different β-lactamases such as blaCTX-M-15 and blaSHV-11. …"
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation حسب Shilpa Kuttikrishnan (3520079)

"…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. …"

Communication, Job Satisfaction and Employees Turnover in Multinational Engineering Organizations in the United Arab Emirates حسب Madi, Mohammed Yazan Ahmad

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Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 حسب Omar M. Khan (17807774)

"…We find that SCFFBW7-mediated ubiquitylation of FBW7 occurs preferentially on K404 and K412, but is not sufficient for its proteasomal degradation, and in addition requires TRIP12-mediated branched K11-linked ubiquitylation. TRIP12 inactivation causes FBW7 protein accumulation and increased proteasomal degradation of the SCFFBW7 substrate Myeloid Leukemia 1 (MCL1), and sensitizes cancer cells to anti-tubulin chemotherapy. …"

Fracture Behavior of ASTM A633 steel plate specimens with edge crack at tensile test حسب Abi Shdid, Caesar

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The effect of self-reported flossing behavior on cardiovascular disease events and mortality Findings from the 2009-2016 National Health and Nutrition Examination Surveys حسب Nebu, Philip

"…BackgroundThere is increasing evidence suggesting that daily oral hygiene self-care measures may alleviate cardiovascular disease (CVD) risk. …"
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An exploration of intelligence management opportunities for organizations in the UAE: Possible challenges for culture حسب BAHERMEZ, ABDULLA OMAR

"…Effective national culture is positively Linked to business intelligence. Besides, business intelligence enables organizations in the UAE To gain useful insights on consumer behavior. …"
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Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue حسب Ali Tiss (437068)

"…Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …"

Tumor protease-activated fusion toxins حسب Abi-Habib, Ralph J.

"…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …"
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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 حسب Harshita Shailesh (14779408)

"…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …"

Inositol 1,4,5-Trisphosphate Receptors in Hypertension حسب Ali H. Eid (5461829)

"…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca²⁺ signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …"

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway حسب Kirti.S. Prabhu (17191231)

"…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …"

A possible culprit for refractory angina حسب Nature Research (16552612)

"…</p><p>This may implicate lipoprotein(a) as having a causal role in refractory angina, but the findings still need to be confirmed by testing a control group of patients who have coronary heart disease but not refractory angina.</p><p>An increased lipoprotein(a) level is known to be highly heritable, and is believed to promote hardening of the arteries by trapping cholesterol in the inner linings of blood vessels, promoting clot formation, recruiting inflammatory cells, or binding pro-inflammatory phospholipids.…"

Development of a multi-zone adiabatic reactor optimization framework for oxidative coupling of methane حسب Murtaza Ali Khan (22804274)

Skopos in Advertising Translation into Arabic حسب Haddad, Khalil

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Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers حسب Nishant Vaikath (3554687)

"…It has been reported that the brains of deceased patients with PD contain high levels of protein oligomers that are cross-linked to these aldehydes. Increasing evidence also suggests that prefibrillar oligomeric species are more toxic than the mature amyloid fibrils. …"

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders حسب Stefan van Duijvenboden (7116386)

"…These findings provide novel insights into how abnormal myocardial repolarization and increased cardiovascular mortality may be linked.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Human Molecular Genetics<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/hmg/ddab197" target="_blank">https://dx.doi.org/10.1093/hmg/ddab197</a></p>…"

Assessment of Qatar’s road network under sea-level-rise scenarios using traffic simulation and graph theory حسب Mohammad Zaher Serdar (17191381)

"…High-resolution maps derived from IPCC-AR6 and NOAA projections show that without adaptation measures, SLR may affect approximately 3–11% of land and 2–17% of roads in Qatar, potentially increasing trip durations up to 15 times. Importantly, the estimated impacts are indicative trends rather than definitive outcomes linked to specific emissions scenarios. …"

Across the Spectrum In-Depth Review AI-Based Models for Phishing Detection حسب Shakeel Ahmad (702854)

"…<p dir="ltr">Advancement of the Internet has increased security risks associated with data protection and online shopping. …"