A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Results WP1066 achieved an IC50 of 1.6 μM, 2.3 μM, and 1.5 μM against melanoma cell line A375, B16 and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of JAK2 and STAT3 (Tyr705) in these cells. …”
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Experimental Design: The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors. …”
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Tumor protease-activated fusion toxins by Abi-Habib, Ralph J.

“…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”

Inositol 1,4,5-Trisphosphate Receptors in Hypertension by Ali H. Eid (5461829)

“…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca²⁺ signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

“…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”

An overview of wide and ultra wide bandgap semiconductors for next-generation power electronics applications by Reshma Ravindran (23157058)

“…<p dir="ltr">High-efficiency <u>power electronic converters</u> are imperative for future applications aiming to meet sustainability goals, as increased efficiency translates to reduced energy consumption. …”

WEB BASED ENGINEERING EDUCATION by , Sheikh

“…The use of Internet for distance education has received increasing attention over the past few years. But the real challenge of adapting this technology for engineering education is to facilitate the laboratory experiments via Internet. …”
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IDENTIFICATION AND CONTROL STRATEGY APPLIED IN LOAD MANAGEMENT OF RESIDENTIAL AIR-CONDITIONERS by Hussain, Syed Ameenuddin

“…Saudi power utilities are under increasing need for controlling the power demand because of severe limitations of power generation resources. …”
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Physical exercise/fitness by Beyrouti, Nouri

“…Both employees and employers will benefit from increased workforce physical fitness. Employees who exercise regularly benefit from improved health and employers with more physically fit workers are likely to reduce their employee health costs and lost productivity. …”
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Solar syngas production via methanothermal reduction of strontium oxide by Rahul R. Bhosale (6467102)

“…Application of heat recuperation considerably decreased the requirement of solar energy input, and hence the process efficiency is further amplified. …”

Potent anti-tumor promoting effects of Daucus carota oil extract in mice by Abou Zeinab, RM

“…Inraperitoneal treatment inhibited tumor yield by 43%, and decreased the tumor volume by 85% at week 20. Gavage treatment failed to inhibit the promotion of tumors but decreased tumor volume by 20%. …”
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The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B... by Saeid Safiri (3713035)

“…Globally, colorectal cancer accounted for 896 000 (876 300–915 700) deaths in 2017, with an age-standardised death rate of 11·5 (11·3–11·8) per 100 000 person-years, which decreased between 1990 and 2017 (−13·5% [–18·4 to −10·0]). …”

The Jordan and Litani rivers in the Middle East. (c1996) by Rizk, Edgar

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Ultrasound‑triggered herceptin liposomes for breast cancer therapy by Elamir, Amal

“…Exposing the liposomes to low-frequency ultrasound (LFUS) triggered drug release which increased with the increase in power density. Trastuzumab conjugation resulted in enhancing the sensitivity of the liposomes to LFUS. …”
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Unsupervised Feature-Based Visualization Tool Applied on Medical Data by Moufarrej, Angela Sleiman

“…In a time when data is experiencing a remarkable growth in different fields, extracting and understanding the correlations between different data features is becoming increasingly important in many application areas, ranging over business, demographics, politics, and medicine, among others. …”
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Evaluation of cell disruption methods for protein and coenzyme Q10 quantification in purple non-sulfur bacteria by Ojima Z. Wada (14155734)

“…However, due to PNSB’s peculiar cell envelope (e.g., increased membrane cross-section for energy transduction) and relatively smaller cell size compared to well-studied microbial protein sources like yeast and microalgae, the effectiveness of common cell disruption methods for protein quantification from PNSB may differ. …”

revisiting credit risk assessment of SMEs by Serov, Vasiliy

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Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment by Christos Fountoukis (4722963)

“…The model’s forecast accuracy was assessed against measurement data from five ground air quality monitoring stations in the greater metropolitan area of Doha over a one-month period. …”