Deletion of TRPC6, an Autism Risk Gene, Induces Hyperexcitability in Cortical Neurons Derived from Human Pluripotent Stem Cells by Kyung Chul Shin (13913556)

“…<p dir="ltr">Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder linked to numerous rare, inherited, and arising de novo genetic variants. …”

Optimization of Cutting Process Parameters in Inclined Drilling of Inconel 718 Using Finite Element Method and Taguchi Analysis by Pervaiz, Salman

“…It can be linked with the higher chip load initially in this case as compared to the 30° inclination angle. …”
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Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway by Yanqing, Li

“…Chronic itch is a common and complex symptom often associated with skin diseases such as atopic dermatitis (AD). Although IL-27 is linked to AD, its role and clinical significance in itch remain undefined. …”
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Genome-Based Characterization of Bacterial Pathogens Causing Bloodstream Infection by Boujanian, Carni

“…Carbapenem resistance and ESBLs were linked to several factors, including variants of NDM such as blaNDM-5 (3/24) and blaNDM-1 (3/24), variants of OXA including blaOXA-1 (9/24) and blaOXA-48 (2/24), and different β-lactamases such as blaCTX-M-15 and blaSHV-11. …”
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The effect of a sand surface on physical performance responses of junior male handball players to plyometric training by Mehrez Hammami (14153331)

“…Both PS and P increased vertical jump performance (squat jump, p = 0.005; ES = 0.170; counter-movement jump p < 0.001; ES = 0.247). …”

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors by Naila Rabbani (291722)

“…<div><p>The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. …”

Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 by Omar M. Khan (17807774)

“…We find that SCFFBW7-mediated ubiquitylation of FBW7 occurs preferentially on K404 and K412, but is not sufficient for its proteasomal degradation, and in addition requires TRIP12-mediated branched K11-linked ubiquitylation. TRIP12 inactivation causes FBW7 protein accumulation and increased proteasomal degradation of the SCFFBW7 substrate Myeloid Leukemia 1 (MCL1), and sensitizes cancer cells to anti-tubulin chemotherapy. …”

Fracture Behavior of ASTM A633 steel plate specimens with edge crack at tensile test by Abi Shdid, Caesar

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The effect of self-reported flossing behavior on cardiovascular disease events and mortality Findings from the 2009-2016 National Health and Nutrition Examination Surveys by Nebu, Philip

“…BackgroundThere is increasing evidence suggesting that daily oral hygiene self-care measures may alleviate cardiovascular disease (CVD) risk. …”
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An exploration of intelligence management opportunities for organizations in the UAE: Possible challenges for culture by BAHERMEZ, ABDULLA OMAR

“…Effective national culture is positively Linked to business intelligence. Besides, business intelligence enables organizations in the UAE To gain useful insights on consumer behavior. …”
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Synthesis of graphene oxide nanofluid based micro-nano scale surfaces for high-performance nucleate boiling thermal management systems by Shoukat Alim Khan (14778226)

“…The highest CHF of 1850 kW/m2 has been observed for GO over the plane surface, increasing 2.31 times. M surface with deionized water resulted in the highest average HTC of 64.36 kW/m².K, increasing 3.47 times. …”

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue by Ali Tiss (437068)

“…Impairment of heat shock response (HSR) has been already linked to diabetes and insulin resistance as reflected by decrease in heat shock proteins (HSPs) expression. …”

Unravelling the predictors of late cancer presentation and diagnosis in Jordan: a cross-sectional study of patients with lung and colorectal cancers by Damsees, Rana

“…The results of backward multivariate logistic regression analyses showed that female gender and not seeking a medical advice when feeling ill combined was associated with an almost three times increased likelihood of reporting a late presentation with cancer (adjusted OR 2.97, 95% CI 1.19 to 7.43). …”
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Skopos in Advertising Translation into Arabic by Haddad, Khalil

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The Activation Kinetics and Crosstalk of RhoGTPases by Al Haddad, Maria

“…Biosensors are two chromophores linked to 2 entities, joined together by a linker which determines their juxtaposition relative to each other, and thus the amount of energy transfer. …”
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Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers by Nishant Vaikath (3554687)

“…It has been reported that the brains of deceased patients with PD contain high levels of protein oligomers that are cross-linked to these aldehydes. Increasing evidence also suggests that prefibrillar oligomeric species are more toxic than the mature amyloid fibrils. …”

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders by Stefan van Duijvenboden (7116386)

“…These findings provide novel insights into how abnormal myocardial repolarization and increased cardiovascular mortality may be linked.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Human Molecular Genetics<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1093/hmg/ddab197" target="_blank">https://dx.doi.org/10.1093/hmg/ddab197</a></p>…”

Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines by Mazhar Pasha (11197767)

“…Persistently activated HIF-1α is associated with increased cell proliferation, angiogenesis, and epithelial–mesenchymal transition (EMT), consequently leading to ccRCC progression and metastasis to other organs. …”

Across the Spectrum In-Depth Review AI-Based Models for Phishing Detection by Shakeel Ahmad (702854)

“…<p dir="ltr">Advancement of the Internet has increased security risks associated with data protection and online shopping. …”

Treatment of electrolyte disorders in adult patients in the intensive care unit by Btaiche, Imad F.

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