Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…In this study, we demonstrate that Prist effectively inhibits the proliferation of T-ALL cell lines (Jurkat and Molt 4) by inducing G0/G1 cell cycle arrest and triggering intrinsic and extrinsic caspase-dependent apoptosis. …”

Tumor protease-activated fusion toxins by Abi-Habib, Ralph J.

“…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …”
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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3 by Harshita Shailesh (14779408)

“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …”

Inositol 1,4,5-Trisphosphate Receptors in Hypertension by Ali H. Eid (5461829)

“…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca²⁺ signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP₃R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …”

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway by Kirti.S. Prabhu (17191231)

“…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …”

A possible culprit for refractory angina by Nature Research (16552612)

“…</p><p>This may implicate lipoprotein(a) as having a causal role in refractory angina, but the findings still need to be confirmed by testing a control group of patients who have coronary heart disease but not refractory angina.</p><p>An increased lipoprotein(a) level is known to be highly heritable, and is believed to promote hardening of the arteries by trapping cholesterol in the inner linings of blood vessels, promoting clot formation, recruiting inflammatory cells, or binding pro-inflammatory phospholipids.…”

Altered regulation of cell migration in IRF6-mutated orofacial cleft patients-derived primary cells reveals a novel role of RhoGTPases in cleft/lip palate development by Al Saneh, Mounir

“…Cleft lip and/or palate (CL/P) affects on average 1 in 700 live births and is considered to be the most common congenital craniofacial birth defect (Setó-Salvia and Stanier 2014). …”
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Globalization and labour markets. (c2004) by Houjeiri, Rana

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Social impact projections for Qatar youth residents from 2022: The case of the IAAF 2019 by Wadih Ishac (18061304)

“…<div><p>While sport is playing an increasingly important role in society in the Middle East, there has been limited research on the perceived social impact of the hosting of major international events in this region. …”

“It's disappointing and it's pretty frustrating, because it feels like it's something that will never go away.” A qualitative study exploring individuals’ beliefs and experiences o... by Jeffrey Turner (341283)

“…</p><h3>Purpose</h3><p dir="ltr">To qualitatively explore the lived experiences of individuals with AT.</p><h3>Design</h3><p dir="ltr">A qualitative, interpretive description design was performed using semi-structured telephone interviews.…”

Internet of everything meets the metaverse: Bridging physical and virtual worlds with blockchain by Wajid Rafique (19757058)

“…It efficiently manages the massive connectivity of physical world objects and enhances security, integrity, and decentralization of trust, while increasing resilience against failures, thus securing and fostering trust in both physical and virtual Metaverse networks. …”

Stressor pileup, family and couple relational well‐being, and parent stress during the COVID‐19 pandemic by Anis Ben Brik (19239442)

“…</p><h3>Method</h3><p dir="ltr">Participants included parents from the U.S. sample of the internet‐based Covid Family Life Study survey who indicated they were married or living with a romantic partner (<i>n</i> = 1,386). …”

The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis by Arwa Aldaalis (13355328)

“…Consequently, inactivation of SREBP1 in human liver and breast cancer cell lines reduces the expression of cyclin D1 and attenuates Rb phosphorylation. …”

Optimizing microgrid efficiency: Coordinating commercial and residential demand patterns with shared battery energy storage by Mohammadreza Gholami (17032317)

“…Moreover, considering DTR for transmission lines, instead of fixed thermal rating, improves the PAR and DPS up to 28.52 % and 41.06 % respectively. …”

Helping patients understand osteoporosis by Nature Research (16552612)

“…Smoking, alcohol and living a sedentary lifestyle are risk factors for the disease. …”

Analysis of Diabetes Apps to Assess Privacy-Related Permissions: Systematic Search of Apps by José Javier Flors-Sidro (18518946)

“…<h3>Background</h3><p dir="ltr">Mobile health has become a major vehicle of support for people living with diabetes. Accordingly, the availability of mobile apps for diabetes has been steadily increasing. …”

Prevalence and risk factors of poor indoor air quality and sick house syndrome symptoms in Dubai by ALI, MUNA IBRAHIM

“…None covered a sample including the different nationalities living in UAE. That is important in revealing more realistic results reflecting the present IEQ and SHS in UAE housing. …”
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The effects of Social Determinants of Health on Type 2 Diabetes Outcomes (A1C) by Awad, Nathalie

“…Diabetes duration of 5-10 years increased the odds of having uncontrolled A1C by more than 3 folds. …”
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Early feeding practices and associated factors in Sudan: a cross-sectional analysis from multiple Indicator cluster survey by Manar E. Abdel-Rahman (5593553)

“…The sample includes women who had a live birth in the two years before the survey and their self-report on early breastfeeding practices, namely early initiation and prelacteal feeding. …”

Predictors of malnutrition among older residents in Qatari long-term care facilities: a retrospective study by Al Anoud Ali H. Z. AlFehaidi (21633416)

“…<h3>Background</h3><p dir="ltr">Malnutrition is a prevalent issue among older adults in long-term care facilities and is associated with adverse health outcomes and increased healthcare costs. Identifying the predictors of malnutrition in this population is crucial for developing effective intervention strategies. …”