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1801
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1802
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1803
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
منشور في 2021"…We find that SCFFBW7-mediated ubiquitylation of FBW7 occurs preferentially on K404 and K412, but is not sufficient for its proteasomal degradation, and in addition requires TRIP12-mediated branched K11-linked ubiquitylation. TRIP12 inactivation causes FBW7 protein accumulation and increased proteasomal degradation of the SCFFBW7 substrate Myeloid Leukemia 1 (MCL1), and sensitizes cancer cells to anti-tubulin chemotherapy. …"
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1804
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1805
A fine-grained XML structural comparison approach
منشور في 2007احصل على النص الكامل
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conferenceObject -
1806
The effect of self-reported flossing behavior on cardiovascular disease events and mortality Findings from the 2009-2016 National Health and Nutrition Examination Surveys
منشور في 2025"…BackgroundThere is increasing evidence suggesting that daily oral hygiene self-care measures may alleviate cardiovascular disease (CVD) risk. …"
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article -
1807
Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline
منشور في 2022"…Currently, there are no disease-modifying therapies or definitive clinical diagnostic and prognostic tools for dementia, and the mechanisms underpinning the link between T2DM and cognitive dysfunction remain equivocal. …"
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1808
An exploration of intelligence management opportunities for organizations in the UAE: Possible challenges for culture
منشور في 2017"…Effective national culture is positively Linked to business intelligence. Besides, business intelligence enables organizations in the UAE To gain useful insights on consumer behavior. …"
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1809
Synthesis of graphene oxide nanofluid based micro-nano scale surfaces for high-performance nucleate boiling thermal management systems
منشور في 2021"…The highest CHF of 1850 kW/m2 has been observed for GO over the plane surface, increasing 2.31 times. M surface with deionized water resulted in the highest average HTC of 64.36 kW/m<sup>2</sup>.K, increasing 3.47 times. …"
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1810
Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue
منشور في 2014"…This expression pattern was concomitant with increased inflammatory response in the adipose tissue as monitored by increased levels of Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), and RANTES (P < 0.05). …"
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1811
Unravelling the predictors of late cancer presentation and diagnosis in Jordan: a cross-sectional study of patients with lung and colorectal cancers
منشور في 2023"…The results of backward multivariate logistic regression analyses showed that female gender and not seeking a medical advice when feeling ill combined was associated with an almost three times increased likelihood of reporting a late presentation with cancer (adjusted OR 2.97, 95% CI 1.19 to 7.43). …"
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article -
1812
Tumor protease-activated fusion toxins
منشور في 2003"…In this study, we demonstrate that DTU2GMCSF is highly potent against AML cell lines in vitro and is not toxic to normal cells both in vitro and in vivo. …"
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masterThesis -
1813
Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
منشور في 2023"…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. However, the role of PRMT5 in breast cancer remains underexplored. …"
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1814
Inositol 1,4,5-Trisphosphate Receptors in Hypertension
منشور في 2018"…This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca<sup>2+</sup> signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP<sub>3</sub>R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. …"
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1815
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
منشور في 2021"…SNG treatment increased Bax/Bcl-2 ratio, which contributed to a leaky mitochondrial membrane leading to cytochrome c release accompanied by caspase activation. …"
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1816
A possible culprit for refractory angina
منشور في 2015"…</p><p>This may implicate lipoprotein(a) as having a causal role in refractory angina, but the findings still need to be confirmed by testing a control group of patients who have coronary heart disease but not refractory angina.</p><p>An increased lipoprotein(a) level is known to be highly heritable, and is believed to promote hardening of the arteries by trapping cholesterol in the inner linings of blood vessels, promoting clot formation, recruiting inflammatory cells, or binding pro-inflammatory phospholipids.…"
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1817
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1818
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1819
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1820
