Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 by Nasser, Selim

“…PrAgU2/LF was cytotoxic to five out of nine AML cell lines. Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. …”
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Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of... by Saeid Safiri (3713035)

“…Age-standardised death rate decreased by 15.7% (8.6 to 21.0), during the period 1990–2019. …”

Clustering records in information retrieval systems. (c1995) by Al-Saffar, Maisaa

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A Comparative study of DAB and Arbitration as methods of resolving Construction Disputes by AL KHAWAJA, DANA JAMAL

“…It is concluded that while the cost of international arbitration may be 15% of a project’s value and may take years to resolve, DAB takes less time. Although time limits increase efficiency relative to arbitration, the ICC rules set time limits for the tribunal’s formation and for submission of rejoinders, but not for the issuance of an award. …”
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Effect of heating rate on the pyrolysis of camel manure by Prakash Parthasarathy (10159511)

“…At the same time, the increase in heating rates improved the char yield from 22.50 to 31.51%. …”

Unsustainability in emergent systems by Haddad, Marc

“…In this paper we present a detailed case study of the passenger road transport system in the Greater Beirut Area (GBA) where we identify the root causes of the major problems facing the system today and over the long-term. …”
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Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shehaby, Wassim N.

“…Flow cytometric analysis indicated that both fractions induced sub-G1 phase accumulation and increased apoptotic cell death. Western blot revealed the activation of caspase-3, PARP cleavage, and a considerable increase in Bax and p53 levels, and a decrease in Bcl-2 level. …”
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Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance by Ajaz A. Bhat (12984701)

“…<p>Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. …”

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications by Pramod Darvin (153341)

“…PD-L1 promoter was significantly hypomethylated in MCF-7 tumorspheres, but not from BT-549 tumorspheres, compared with their cell line counterparts. The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”

Types of PMO and their roles in the UAE Oil & Gas Production Companies by Mohamed, Walid Ramadan Ibrahim

“…Some researchers argued that this failure might be due to the increase in the concurrent projects number in big organizations which were increasing the project management complexity while competing, and in the same time depleting the organization resources. …”
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Spatiotemporal mapping of groundwater salinity in Al-Batinah, Oman by Ammar, Abulibdeh

“…A salinity map was created to track the changes in groundwater salinity over time in the study area. The results show that water salinity increases over time due to the increase in urbanization and over-pumping of water from these wells. …”
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Modifying cellulose fibres with carbon dots: a promising approach for the development of antimicrobial fibres by Radha, Remya

“…Cytotoxicity assays on human cell lines showed no toxicity towards cells at concentrations of up to 100 µg ml−1 but exhibited increased toxicity at concentrations exceeding 1000 µg ml−1. …”
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Unraveling the future productivity burden of cardiovascular disease in Qatar: Investigating the modifiable risk factors control in type 2 diabetes by Dina Abushanab (10696501)

“…The financial value of PALYs was determined based on the gross domestic product (GDP) per full-time worker (i.e. US$80,573). The base-case model estimated the productivity burden of CVD, and interventional scenarios were simulated to assess potential gains resulting from improved control of modifiable risk factors, including reduced incidence of T2D, lower systolic blood pressure (SBP), decreased number of smokers, and reduced total cholesterol. …”

YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm by Prabu Selvam (22330264)

“…Compared to the standard YOLOv11 model, the proposed YOLO-DefXpert attained an improvement of 9.3% and 13.2% in mAP50 and mAP95, an 11.25% increase in frames per second, and a 69.85MB decrease in model size. …”

The Impact of Labor Migration on Couple and Family Relationships and Dynamics: The Lebanese Women's Perspective by Arab, Nabila

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Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia by Luisa Tomasello (702932)

“…Furthermore, we demonstrated that the increased expression of β-catenin in PTPRG-negative CML cell lines correlates with DNA (cytosine-5)-methyl transferase 1 (DNMT1) over-expression, which is responsible for PTPRG promoter hypermethylation, while its inhibition or down-regulation correlates with PTPRG re-expression. …”

Spatiotemporal mapping of groundwater salinity in Al-Batinah, Oman by Ammar Abulibdeh (15785928)

“…A salinity map was created to track the changes in groundwater salinity over time in the study area. The results show that water salinity increases over time due to the increase in urbanization and over-pumping of water from these wells. …”

What drives cryptocurrency pump and dump schemes: Coin versus market factors? by Lanouar Charfeddine (10705000)

“…Furthermore, the study employs count time-series models to examine market-based factors. …”

Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans by Kirti S. Prabhu (4246144)

“…In addition to cell lines, we assessed the impact of BTZ in an in vivo setting using Caenorhabditis elegans (C. elegans). …”

The present and future disease burden of hepatitis C virus infections with today's treatment paradigm – volume 3 by Mokhbat, J. E.

“…The total number, morbidity and mortality attributed to viraemic hepatitis C virus (HCV) infections change over time making it difficult to compare reported estimates from different years. …”
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