Investigating The Efficacy of Ruxolitinib and CHIR-99021 in Targeting Pediatric Neuroblastoma Stem Cells حسب Al Sayyed, Fatima

"…In this study, we investigate the efficacy of two small molecules Ruxolitinib, a JAK/STAT inhibitor, and CHIR-99021, a GSK-3 inhibitor, in targeting pediatric neuroblastoma stem cells by testing them on human MYC-N amplified, IMR-32, and non-MYC-N amplified, SK-N-SH, cell lines. Treating neuroblastoma cells with Ruxolitinib and CHIR-99021 resulted in significant reduction in cellular proliferation, viability, apoptosis and tumorsphere formation capacity in both IMR-32 and SK-N-SH cell lines. …"
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Effectiveness of communication processes in Agile Project Management Approach in the UAE Utility Sector حسب AFIFI, MUTASIM ABDALLA HASSAN

"…Team members should have a voice in the agile project management process, maintain open lines of communication with stakeholders, and discuss problems in a timely manner to increase tolerance and acceptance.…"
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Reduction of laboratory utilization in the intensive care unit حسب Diab, Khalil

"…The number of iSTAT laboratory tests per patient-day decreased from 7.37 to an average of 1.16 (P < .001) over the same time period. …"
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Evapotranspiration and water availability response to climate change in the Middle East and North Africa حسب Salah Basem Ajjur (14150967)

"…Outcomes reveal that the MENA region is indeed vulnerable to a surge in temperature, which can increase evapotranspiration losses and decrease water availability. Under the shared socioeconomic pathway (SSP2-4.5), the potential evapotranspiration (PET) has been projected to increase throughout the MENA region by up to 0.37 mm per year during the middle of the twenty-first century (2021–2050) and by up to 0.51 mm per year during the end of the twenty-first century (2071–2100). …"

Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis حسب George Nitzburg (18614989)

"…Second, we examined symptom queries preceding queries on the 12-step program at time lags of 0-7 days, 7-14 days, and 14-30 days, where the probability of asking about a medical symptom was greater in the 30-day time window preceding 12-step program information-seeking as compared to all previous times that the symptom was queried.…"

Guidelines for the pharmacological treatment of peripheral neuropathic pain حسب Riachi, N.

"…The expert panel recommended pregabalin, gabapentin and secondary amine tricyclic antidepressants (nortriptyline and desipramine) as first-line treatments for peripheral NeP. Serotonin-norepinephrine reuptake inhibitor antidepressants, tramadol and controlled-release opioid analgesics were recommended as second-line treatments. …"
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Can Leadership-coaching Mind-set Substitute that of Crisis Management in Higher Education? حسب Chaika, Oksana

"…The term ‘crisis management’ includes the three stages, i.e. pre-crisis, crisis per se, and post-crisis management in higher education. …"
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Kefir induces cell-cycle arrest and apoptosis in HTLV-1-negative malignant T-lymphocytes حسب Rizk, Sandra

"…The percent reduction in proliferation was very significant, and was dose-, and time-dependent. In both cell lines, kefir exhibited its antiproliferative effect by downregulating TGF-α and upregulating TGF-β1 mRNA expression. …"
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Targeting acute myeloid leukemia cells with novel photosensitive ruthenium-based metal-organic compounds. (c2015) حسب Azar, Daniel Fadi

"…Furthermore, we have attempted to examine the photochemical potential of our metal-organic compound model by combining L-II and L-III in the same metal complex, thus generating four final complexes with differing net charges (from +2 to -4), and examining their activities on a panel of AML cell lines with or without exposure to blue light. Of the four final complexes Ru-II3, Ru-II2-III, Ru-II-III2 and Ru-III3, only Ru-II3 and Ru-II2-III have shown significant activity against all tested cell lines in the dark, whereas photo-activation against ML2 has shown a marked increase of potency of all four complexes, even those shown to be biologically inert in the dark, reaching IC50 values in the nM range. …"
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The July war and its effects on Lebanon’s power-sharing حسب Fakhoury, Tamirace

"…On a broader scale, this article helps shed light on the dilemma of power-sharing systems on stormy seas when external conflicts overlap with internal conflict lines.…"
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Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute... حسب Farhat, Mirna

"…Finally, while IMC/LF treatment did not affect the expression of any of the proteases tested (uPAR, MMP2, and MMP9), treatment with IMC/FP59 did affect their expression with significant cytotoxic responses seen only in cells whose uPAR expression was not affected at any time point post-treatment. In this study, we showed for the first time the potency of IMC PrAg variant on AML cell lines, its mode of action, as well as its mechanism of cell death.…"
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance حسب Zouhaier Farhani (22330693)

"…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…"

Anticancer and antioxidant effects of tragopogon porrifolius extract. (c2011) حسب Tenkerian, Clara A.

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Phenotypic and Proteomic characterization of Clinical Candida albicans isolates resistant to Fluconazole حسب Geukgeuzian, Giovanni

"…The azole fluconazole is the first line of defense in hospital treatment. Azoles function by inhibiting Erg11 an enzyme involved in the synthesis of ergosterol, the main sterol found in fungi. …"
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Epidemiological and clinical characteristics of fall-related injuries: a retrospective study حسب Ahammed Mekkodathil (4578838)

"…</p> <h2>Results</h2> <p>A total of 4040 patients with fall-related injuries were identified in the study duration which corresponds to the rate of 2.34 per 10,000 population. Although the rate of fall-related injuries decreased over the years, the average number of patients per year remained high accounting for 32% of the hospitalized patients with moderate to severe injuries. …"

Organizational Strategy and Employee Productivity in Oil and Gas Industry: The Case of the United Arab Emirates حسب Al-Ansari, Haima Ali Al-Mulla

"…Owing to the advent of globalization, there is an increasing demand for improved productivity and increased efficiency from employees. …"
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The Anti-Tumor Effect of Flaxseed Lignan Derivatives on Different Acute Myeloid Leukemia Cancer Cells حسب Tannous, Stephanie

"…Cytotoxicity assays, using WST-1, revealed dose- and time- dependent effects in various AML cell lines with the most prominent cytotoxicity exhibited by ENL. …"
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Application of Fe₃O₄ magnetite nanoparticles grafted in silica (SiO₂) for oil recovery from oil in water emulsions حسب Wamda Faisal Elmobarak (17058024)

"…Using an MD_dose as low as 10 mg/L attained a %_hdem in the range of 93% - 4.3% for O/W mixtures with C_oil < 2000 mg/L, which slightly decreased to ~90% for higher concentrations. The reported %R_oil(p-value <0.05) was >90 ± 0.1 for tests carried out with pH 7 and C_sur0.1 g/L and declined at higher pH and Csur to % 86.5 due to the increase in emulsion stability. …"

Are wars detrimental to the environment? Evidence from air pollution and land use حسب Marrouch, Walid

"…We find that, although wars decrease per capita CO2 emissions, they increase CO2 intensity. …"
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Formation of Bromate in Pet Bottle Water حسب Sharif, Haifa

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