Old subjects with sepsis in the emergency department: trend analysis of case fatality rate by Andrea Fabbri (356760)

“…The relative proportion of subjects ≥80 years (overall, 52.9% of cases) and classified as high-risk did not change along the years. CFR decreased only in low-risk subjects (from 13.3 to 5.2%; P < 0.001), and particularly in those aged ≥80 (from 18.2 to 6.6%; P = 0.003), but not in high-risk individuals (from 69.9 to 64.2%; P = 0.713).…”

Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery by Stephen L. Atkin (6684368)

“…<h3>Background: </h3><p dir="ltr">Early metabolic responses following bariatric surgery appear greater than expected given the initial weight loss and coincide with improvement in diabetes. …”

Understanding the phenomenon of saltwater intrusion sourced from desalination plants at coastal aquifers by Farhat Abbas (5480)

“…Column Peclet numbers from the two analyses were identical for potassium ions but those for bromide ions were c. 60% greater from the two-region model than from the convective–diffusion equation. …”

Comparative study of the parameters affecting the performance of microchannels' heat exchangers: Latest advances review by Muhammad Asim (2235472)

“…Apart from this, investigating the inlet/outlet arrangement through finite volume method for D‐, I‐, N‐, S‐, U‐, and V‐type arrangements, it is evident that the V‐type sink has overall greater performance. In terms of gravity, it is observed that it has no effect on the performance of microchannel heat exchangers. …”

Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12 by Kripa S Keyan (10644815)

“…<p dir="ltr">Transforming growth factor β (TGFβ) pathway is a master regulator of cell proliferation, differentiation, and death. …”

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Michael, Brauer

“…For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. …”
Get full text
Get full text
Get full text

Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma by Abou-Ghazal, Mohamed

“…In addition, WP1066 decreased the level of c-Myc and survivin in melanoma cells in a dose- and time-dependent manner. …”
Get full text
Get full text
Get full text

The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women by Thozhukat Sathyapalan (704787)

“…Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT₄) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT₃ correlated with TSH in both studies (<i>p</i> = 0.03) but not with either fT₃ or fT₄. fT₃ levels did not differ between the SPI and SP preparations.…”

Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analy... by Hmwe Hmwe, Kyu

“…The most pronounced decline was in children younger than 5 years, with a 79·2% (72·4–84·6) decrease in diarrhoeal deaths. Global YLLs also decreased substantially, from 186 million (147–221) in 1990 to 51·4 million (39·9–65·9) in 2021. …”
Get full text
Get full text
Get full text

Risk factors for stoma outlet obstruction: systematic review and meta-analysis by Ali Toffaha (18111886)

“…<h3 dir="ltr">Introduction</h3><p dir="ltr">Stoma outlet obstruction (SOO) is a serious postoperative complication that can lead to significant morbidity, including prolonged hospitalization, increased healthcare costs, and reduced quality of life. …”

Association between clinical laboratory indicators and WOMAC scores in Qatar Biobank participants: The impact of testosterone and fibrinogen on pain, stiffness, and functional limi... by Ovelia Masoud (22282864)

“…This study explored the relationship between clinical laboratory profiles and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores for pain, stiffness, and physical functional limitation in healthy individuals in Qatar.…”

Anti-xa guided enoxaparin thromboprophylaxis is associated with less thromboembolism than fixed dose dalteparin in trauma patients admitted to intensive care by Ahmad Kloub (16855149)

“…VTE incidence after protocol implementation decreased from 4 to 1.3% (OR 0.31; 95% CI 0.1–0.9, P = 0.03) without increasing the bleeding rate. …”

The impact of metformin therapy for gestational diabetes on fetal growth in women with risk factors for fetal growth restriction- a registry-based study from Qatar by Komal Rafique (17075074)

“…However, the centiles were higher in those who took metformin compared to those who did not. Regardless of risk factor status, women taking metformin had higher risk of LFD (p=0.001), but no difference in risk of macrosomia.…”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…Similarly, KO 47 mice also showed a slower rate of glucose clearance in GTT that was consistent with decreased mRNA expression of the GLUT4 gene in WAT but not in the muscle. …”

Monitoring the Athlete Match Response: Can External Load Variables Predict Post-match Acute and Residual Fatigue in Soccer? A Systematic Review with Meta-analysis by Karim Hader (2548618)

“…For every 100-m run above 5.5 m·s⁻¹, CK activity measured 24 h post-match increased by 30% and CMJPPO decreased by 0.5%. Conversely, the total distance covered did not present any evidence of a clear relationship with any fatigue-related marker at any time-point.…”

The role of IT governance in enhancing the competitiveness of for-profit private schools' business by Jasim, Alaa H

Get full text

The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global B... by Saeid Safiri (3713035)

Targeting acute myeloid leukemia cells with novel photosensitive ruthenium-based metal-organic compounds. (c2015) by Azar, Daniel Fadi

Get full text
Get full text

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis by Meritxell Espino‐Guarch (22565774)

“…Further, chronic Gln accumulation and decreased proteolysis were found to induce the early onset of an age‐related muscle phenotype.…”

Urban Geometry: The Effect of Height Diversity and Buildings Configuration on Thermal Performance and Cooling Load at Urban Scale. A Case Study in Dubai / UAE by SHAREEF, SUNDUS LUAY

“…The variation along the short direction of the urban block has a greater positive effect and the saving in cooling energy consumption reaches 4.6 %. …”
Get full text