Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... by Muhanad Alhujaily (11630107)

“…Spliceosomal gene expression correlated positively with Glo1 in human tumor cell lines and tumors. In clinical chemotherapy of breast cancer, increased expression of Glo1 was associated with decreased patient survival, with hazard ratio (HR) = 1.82 (logrank p < 0.001, n = 683) where upper quartile survival of patients was decreased by 64% with high Glo1 expression.…”

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications by Fang Yu (156838)

“…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.…”

Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study by Obaidullah Zafar (17910572)

“…These findings highlight the need for individualized IV iron therapy as a first-line treatment in young healthy patients to improve outcomes and optimize healthcare resources.…”

Breaking the barriers towards large-scale microalgae-based bio-hydrogen production by Isra Koko (22631396)

“…A CSTR nutrient-recovery line on digested <i>Scenedesmus</i> recovered 68 % N and 72 % P via struvite, reducing synthetic fertilizer ∼35 %; flue-gas CO₂ (12 % v/v) lifted biomass 22 % and reduced carbon-supplement cost 86 %. …”

Clinical characteristics and outcome of children with acute cryptorchid testicular torsion: A single-center, retrospective case series study by Zlatan Zvizdic (9212371)

“…Preoperative color Doppler ultrasonography revealed absent or decreased testicular blood flow in the affected testes in 7/8 of patients. …”

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome by Abu Saleh Md Moin (6189512)

“…These protein panels target biological processes involved in vessel damage, platelet degranulation, the coagulation cascade and the acute phase response [1], with greater protein changes dependent on the COVID-19 severity. …”

Coping mechanisms among Lebanese first-time college students by Doumit, Rita

“…Strategies xiv used varied with the type of situation. A greater proportion of overall strategies used included active and internal coping strategies which were focused on resolving the issue or problem. …”
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A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country by Nancy Zaghloul (14147865)

“…The trend among SGLT2is suggests greater preference for empagliflozin over dapagliflozin.…”

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells by Ali Alhoshani (3720718)

“…</p><h3>Methods</h3><p dir="ltr">Breast cancer cell lines with different molecular subtypes (MDA-MB-231, MCF7, and SKBR-3) were treated with different concentrations of VCX for indicated time points. …”

Crystallization properties of arsenic doped GST alloys by Vinod E. Madhavan (8136774)

“…Optical band gap (E_opt) values of the as-deposited films show a clear increasing trend; 0.6 eV for GST to 0.76 eV for (GST)_0.85As_0.15. The decreases in E_opt for the samples annealed at higher temperatures shows significant optical contrast between the as-deposited and annealed samples. …”

Application of Fe₃O₄ magnetite nanoparticles grafted in silica (SiO₂) for oil recovery from oil in water emulsions by Wamda Faisal Elmobarak (17058024)

“…Demulsification process best fits the combined Langmuir-Freundlich (L-F) isotherm with highest adsorption capacity (Q_max) of 186.0 ± 5 mg_oil/g_MD compared to 86.0 ± 5 mg_oil/g_MD for Fe₃O₄, which is 1.1 folds greater than Q_max reported in the literature for other demulsifiers.…”

Masked phenomenon: renal and cardiovascular complications; review and updates by Elmukhtar Habas (14777677)

“…The masked phenomenon (MP) (MHTN and MUHTN) increases susceptibility to end-organ damage (a two-fold greater risk for cardiovascular events and kidney dysfunction). …”

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients by Esraa K. Al-Amleh (16023071)

“…With regards to the treatment effect on hematological parameters, notably in CML patients in later stages, the combination therapy (HU + IM) raised lymphocyte count, indicating a greater response to the treatment. When compared to single medicines, the combination treatment reduced the proportion of neutrophils to normal reference ranges. …”

Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer by Adviti Naik (673163)

“…Silencing LDHC in breast cancer cell lines (MDA-MB-468, BT-549, HCC-1954) enhanced early T cell activation and cytolytic activity. …”

The relationship between Determinants of Risk Governance assurance and efficacy of the Public projects in the Government of Dubai from the perspective of Internal Audit Function by MUBARAK, ALIA MARJAN

“…These mega-projects may include the construction of major buildings, roads, railway lines and airports. The success of these public initiatives may create the course for the government to decrease its reliance on other sectors. …”
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Fractionation and phytochemical composition of an ethanolic extract of Ziziphus nummularia leaves: antioxidant and anticancerous properties in human triple negative breast cancer c... by Rola Abdallah (22484130)

“…F6 decreased MDA-MB-231 viability more than crude ZNE or its other fractions. …”

Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery by Stephen L. Atkin (6684368)

“…<h3>Background: </h3><p dir="ltr">Early metabolic responses following bariatric surgery appear greater than expected given the initial weight loss and coincide with improvement in diabetes. …”

Understanding the phenomenon of saltwater intrusion sourced from desalination plants at coastal aquifers by Farhat Abbas (5480)

“…Column Peclet numbers from the two analyses were identical for potassium ions but those for bromide ions were c. 60% greater from the two-region model than from the convective–diffusion equation. …”

Comparative study of the parameters affecting the performance of microchannels' heat exchangers: Latest advances review by Muhammad Asim (2235472)

“…Apart from this, investigating the inlet/outlet arrangement through finite volume method for D‐, I‐, N‐, S‐, U‐, and V‐type arrangements, it is evident that the V‐type sink has overall greater performance. In terms of gravity, it is observed that it has no effect on the performance of microchannel heat exchangers. …”

Mixed siliciclastic-carbonate-evaporite sedimentation in an arid eolian landscape: The Khor Al Adaid tide-dominated coastal embayment, Qatar by John M., Rivers

“…The overall landward increase in salinity is accompanied by a decrease in the diversity of benthic fauna and their skeletal remains. …”
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