Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Michael, Brauer

“…For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. …”
Get full text
Get full text
Get full text

Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Stud... by Robert C Reiner (5147636)

“…Findings The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1–65·8), 17·4% (7·7–28·4), and 59·5% (34·2–86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. …”

Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 by Hmwe Hmwe Kyu (8674014)

“…During the same period, LRI episodes and deaths in children younger than 15 years were estimated to have decreased, and the greatest decline was observed for LRI deaths in males younger than 5 years (–70·7% [–77·2 to –61·8]). …”

Human recombinant arginase I(Co)-PEG5000 [HuArgI(Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells by Bekdash, Amira

“…In this study, we target arginine auxotrophy of AML cell lines using human arginase I cobalt-PEG5000. HuArgI(Co)-PEG5000 was cytotoxic to all AML cell lines tested. …”
Get full text
Get full text
Get full text

The mechanisms of resistance of anthrax lethal toxin (LeTx)-induced cytotoxicity in AML cells. (c2018) by Abou Harb, Monica

“…Our results indicate that vertical inhibition by SCH772984 rendered the resistant cell lines sensitive to the inhibition of the MAPK-pathway and showed an increased cytotoxic effect once used in combination with anthrax lethal toxin compared to the use of anthrax lethal toxin alone.…”
Get full text
Get full text
Get full text

Potential mechanisms of human recombinant arginase I (Co)-PEG5000 [HuArgI (CO) - PRG5000] induced cytotoxicity in glioblastoma cells. (c2018) by El Jawhari, Yassmine

“…Cytotoxicity of [HuArgI (Co)-PEG5000] was tested on two GBM cell lines, namely A172 and U251. Both cell lines showed increased sensitivity at longer incubation periods of [HuArgI (Co)-PEG5000] treatment with IC50 values in the pM range, a result attributable to the arginine auxotrophy expressed in those two cell lines. …”
Get full text
Get full text
Get full text

Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans by Kirti S. Prabhu (4246144)

“…In addition to cell lines, we assessed the impact of BTZ in an in vivo setting using Caenorhabditis elegans (C. elegans). …”

Modifying cellulose fibres with carbon dots: a promising approach for the development of antimicrobial fibres by Radha, Remya

“…Cytotoxicity assays on human cell lines showed no toxicity towards cells at concentrations of up to 100 µg ml−1 but exhibited increased toxicity at concentrations exceeding 1000 µg ml−1. …”
Get full text

Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 by Natalia V, Bhattacharjee

“…Additionally, the distribution of livebirths across the globe is shifting, with a greater proportion occurring in the lowest-income countries. …”
Get full text
Get full text
Get full text

The Anti-Proliferative and Pro-apoptotic Effect of Topotecan in Combination With Thymoquinone in Acute Myelogenous Leukemia by Rizk, Sandra

“…Topotecan (a novel topoisomerase I inhibitor and a water-soluble camptothecin analog) is active against numerous human tumor cell lines, and has shown promising antineoplastic activity in solid tumors and acute leukemia. …”
Get full text
Get full text
Get full text

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF) 1 by Nasser, Selim

“…PrAgU2/LF was cytotoxic to five out of nine AML cell lines. Cytotoxicity of PrAgU2/LF appeared to be nonapoptotic and was associated with MAPK activation and urokinase activity because all the PrAgU2/LF-sensitive cell lines showed both uPAR expression and high levels of MEK1/2 phosphorylation. …”
Get full text
Get full text
Get full text
Get full text

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia by Shilpa Kuttikrishnan (3520079)

“…Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID. …”

Water-pipe smoking promotes epithelial–mesenchymal transition and invasion of human breast cancer cells via ERK1/ERK2 pathways by Khaled W. Sadek (14153196)

“…Two breast cancer cell lines, MCF7 and BT20, were used in this investigation. …”

Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy by Nassiba Taib (14557385)

“…</p><h2>Methods</h2><p dir="ltr">We compared the effect of DAC in primary 1076 Col and metastatic 1872 Col cell lines isolated and generated from patients’ tumor tissues. …”

The Candida albicans Hwp2 is necessary for proper adhesion, biofilm formation and oxidative stress tolerance by Dimassi, Hani I.

“…It appears that Hwp2 is necessary for proper oxidative stress tolerance, adhesion and biofilm formation as an hwp2 null is more susceptible to increasing doses of hydrogen peroxide, unable to adhere efficiently to epithelial and endothelial cell lines and unable to form wild type biofilm levels.…”
Get full text
Get full text
Get full text

Kefir inhibits proliferation and induces apoptosis of epithelial colorectal adenocarcinoma cells. (c2011) by Hayek, Stephanie E.

Get full text
Get full text

Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells by Khoury, Oula

“…We tested and characterized the activity of HuArgI (Co)-PEG5000 on a panel of 9 GBM cell lines and on human fetal glial cells (SVG-p12). HuArgI (Co)-PEG5000 was cytotoxic to all GBM cells tested. …”
Get full text
Get full text
Get full text

INTEGRATING TRADITIONAL AND UNCONVENTIONAL CSR THEORIES AND MODELS – A THEORETICAL by Rajeev, Dr. Bhavana

“…The surge in financial scandals, widening gaps in social inequality, increasing political and financial muscle by MNC’s, global uncertainties as well as environmental degradation has put the spotlight on firms to strengthen their involvement and be sensitive to socially responsible activities. …”
Get full text

Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells by Zgheib, Perla

“…Upon treatment, a pronounced decrease in cancer cell motility was observed in the 4 cell lines. The treatment also led to a decrease in cancer cell invasion and an increased cell adhesion. …”
Get full text
Get full text
Get full text
Get full text

The impact of political alliances on voter prejudice in post conflict countries by Ouaiss, Makram E.

“…Scholars of conflict resolution have studied ways to reduce prejudice in society for years, believing that prejudice leads to or increases the likelihood of conflict. The primary focus has been on schools, universities and communities. …”
Get full text
Get full text
Get full text