Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors by Noura Aldous (15429873)

“…Recent studies have also shown <i>RFX6</i> variants to be linked with type 2 diabetes. Despite RFX6’s known function in islet development, its specific role in diabetes pathogenesis remains unclear. …”

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1 by Bushra Memon (4792767)

Challenges in child and adolescent health across the Arab Gulf countries—Focus on metabolic health by Basma Haris (12040355)

“…The combination of an increasing youth population combined with rapid modernisation, increasing per capita income and the paradigm shift towards unhealthy and affluent lifestyles has created a significant burden of non‐communicable diseases (NCDs), especially obesity and diabetes. …”

Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors by Najlaa A. Al Thani (17788493)

“…<p dir="ltr">Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering blood glucose levels effectively via increasing the glomerular excretion of glucose. …”

Successful use of MiniMed 780G during pregnancy by Khaled Ahmed Baagar (17032266)

“…<h3>Background</h3><p dir="ltr">Pregnancy in the setting of type 1 diabetes (T1D) is associated with increased morbidity and mortality. …”

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression by Mohamed Abu-Farha (25322)

“…Nevertheless, DNAJB3 expression pattern in diabetic subjects and its mode of action are not yet known. …”

A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country by Nancy Zaghloul (14147865)

“…The trend among SGLT2is suggests greater preference for empagliflozin over dapagliflozin.…”

Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors by Naila Rabbani (291722)

“…<div><p>The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. …”

Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone by Abdoulaye Diane (14152749)

“…A similar increase in DNAJB3 mRNA was also observed in HepG2 cells. …”

Association of Differing Qatari Genotypes with Vitamin D Metabolites by Youssra Dakroury (9991407)

“…This may be of specific importance in vitamin D replacement strategies with the Q2 genotype requiring less, and the other genotypes requiring more to increase 1,25(OH)2D. Whilst overall the group was vitamin D deficient, total 25(OH)D was higher in diabetes, but 1,25(OH)2D, 24,25(OH)2D, and 3epi-25(OH)D were lower in diabetes that did not affect the relationship to genotype.…”

Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal by Zehra Irshad (18614869)

“…<p dir="ltr">Metabolic dysfunction of endothelial cells in hyperglycemia contributes to the development of vascular complications of diabetes where increased reactive glycating agent, methylglyoxal (MG), is involved. …”

Driving and hypoglycemia by Stephen Beer (5480411)

“…Unfortunately most diabetes medication can cause hypoglycemia. Hypoglycemia has been associated with cardiac arrhythmia, a decreased ability to drive and driving mishap. …”

The promise of tirzepatide: A narrative review of metabolic benefits by Sara Sokary (17337724)

“…<p>Obesity and type 2 diabetes mellites (T2DM) are intertwined epidemics that continue to pose significant challenges to global public health. …”

PDX1⁻/NKX6.1⁺ progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells by Bushra Memon (4792767)

“…<h3>Aim</h3><p dir="ltr">Beta cell replacement strategies are a promising alternative for diabetes treatment. Human pluripotent stem cells (hPSCs) serve as a scalable source for producing insulin-secreting cells for transplantation therapy. …”

Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula by Oyelola A. Adegboye (4287826)

Sense and Learn: Recent Advances in Wearable Sensing and Machine Learning for Blood Glucose Monitoring and Trend-Detection by Ahmad Yaser Alhaddad (7017434)

“…There is an increasing demand for non-invasive blood glucose monitoring and trends detection amongst people with diabetes and healthy individuals, especially athletes. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…<p dir="ltr">Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of DNAJB3 mRNA and protein in subjects with obesity, which was concomitant with increased metabolic stress. …”

DNAJB3 attenuates ER stress through direct interaction with AKT by Zeyaul Islam (5867387)

“…<p dir="ltr">Metabolic stress involved in several dysregulation disorders such as type 2 diabetes mellitus (T2DM) results in down regulation of several heat shock proteins (HSPs) including DNAJB3. …”

Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar by Dalal Al‐Sharshani (19479814)

“…<h3>Background</h3><p dir="ltr">Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD).…”

"Development of Authentic Annual and Seasonal Lightning Thunderstorms Day Maps for Saudi Arabia" by Shwehdi, M. H.

“…The southern region in general, and especially the cities of Abha, Taif and Al-Baha, has shown greater numbers of thunderstorm days all year round. …”
Get full text