Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments حسب Gunjan Dagar (9339276)

"…Bi-specific chimeric antigen receptors may contribute to mitigating tumor antigen escape, but their efficacy could be limited in cases where certain tumor cells do not express the targeted antigens. …"

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity حسب Vijay Gupta (209146)

"…The purified scFvs showed specific activity towards α-syn fibrils and oligomers in comparison to monomers and recognized intracellular inclusions in human post-mortem brain tissue of Lewy body disease cases, but not aged controls. In vitro studies indicated scFvs inhibit the seeding of α-syn aggregation in a time-dependent manner, decreased α-syn seed-induced toxicity in a cell model of PD, and reduced the production of insoluble α-syn phosphorylated at Ser-129 (pS129-α-syn). …"

Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31 حسب Jonathan D. J. Labonne (18090841)

"…Using another affected member, DGDP289B, with a microdeletion at Xp22.31, in this family, we performed the genomic and clinical delineation with six published and nine unreported cases. We propose HDHD1 and PNPLA4 for X-linked intellectual disability in this region, since their high transcript levels in the human brain substantiate their role in intellectual functioning.…"

Ozone and ozone/hydrogen peroxide treatment to remove gemfibrozil and ibuprofen from treated sewage effluent: Factors influencing bromate formation حسب Hajar Farzaneh (18526782)

"…Bromate formation was decreased to 0.012 mg/L when the pH was increased to 9. …"

Understanding the Mechanism of Diabetes Mellitus in LRBA-Deficient Patient حسب Iman Hawari (12561958)

"…To our knowledge, all reported cases of diabetic patients with LRBA mutation were compiled in this research. …"

Psychological and Coping Strategies Related to Home Isolation and Social Distancing in Children and Adolescents During the COVID-19 Pandemic: Cross-sectional Study حسب Abduljaleel Abdullatif Zainel (18055382)

"…<h3>Background</h3><p dir="ltr">In December 2019, a novel coronavirus called SARS-CoV-2 was identified as the cause of a cluster of pneumonia cases in Wuhan, China. It rapidly spread due to human-to-human transmission, resulting in a global pandemic. …"

Automatic image quality evaluation in digital radiography using for‐processing and for‐presentation images حسب Ioannis A. Tsalafoutas (14776939)

"…The expected positive effect that increasing IAK and decreasing tube potential should have on IQ was clearly exhibited in two IQ metrics only, the signal difference‐to‐noise‐ratio (SDNR) and the detectability index (d’), for both image types. …"

Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas حسب Abu Saleh Md Moin (6189512)

"…</p><p dir="ltr"><br></p><h3>Results: </h3><p dir="ltr">CPHN cell frequency decreased 84% (islets) and 42% (clusters) from fetal to infant life. …"

Examining time-to-transport decisions in Emergency Medical Services حسب Hassan Farhat (9000509)

"…</p><h3>Methods</h3><p dir="ltr">We conducted a comprehensive time-to-event analysis of HMCAS electronic patient care record system data from January to February 2023, representing 93,712 emergency cases attended to, using R Studio to understand the time from when an ambulance is dispatched until it is available for the subsequent call. …"

Peripheral inflammatory and metabolic markers as potential biomarkers in treatment-resistant schizophrenia: Insights from a Qatari Cohort حسب Mohamed Adil Shah Khoodoruth (14589828)

"…The Random Forest model, a supervised machine learning algorithm, efficiently differentiated between cases and controls and between TRS and NTRS, with accuracies of 86.87 % and 88.41 %, respectively. …"

Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature حسب Henry C. Ezechukwu (13253406)

"…Decidual vasculopathy (3.2%), infarction (3.2%), chronic histiocytic intervillositis (6.0%), thrombi vasculopathy (5.1%) were also observed in most of the MVM and FVM reported cases. The results indicated that SARS-CoV-2 induces placenta inflammation, and placenta susceptibility to SARS-CoV-2 decreases across the pregnancy window. …"

Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study حسب Rajesh, Sharma

"…Between 1990 and 2019, deaths due to 17 of the 29 cancers either doubled or more, and 20 of the 29 cancers underwent an increase of 150% or more in terms of new cases. Tracheal, bronchus, and lung cancer (both sexes), breast cancer (among females), colon and rectum cancer (both sexes), stomach cancer (both sexes) and prostate cancer (among males) were among top-5 cancers in most Asian countries in terms of ASIR and ASMR in 2019 and cancers of liver, stomach, hodgkin lymphoma and esophageal cancer posted the most significant decreases in age-standardized rates between 1990 and 2019. …"
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Appropriateness of gentamicin therapeutic drug monitoring at a Middle Eastern tertiary hospital setting: a retrospective evaluation and quality audit حسب Fatima Khalifa Al-Sulaiti (14152056)

"…Inappropriate sampling time relative to the last dose was captured in 31% (<i>n</i> = 18) of the cases. Although 27.6% (<i>n</i> = 16) of gentamicin concentrations were non-therapeutic, continuing gentamicin dosing without adjustment was the most frequent post-analytical action (69.8%, <i>n</i> = 37). …"

Immunoprofile of childhood diabetes حسب Meritxell Espino-Guarch (15430868)

"…Associated with these findings, anti-inflammatory Treg cytokines including IL-10 were decreased in T2D patients and elevated plasma levels of IL-17, which contributes to the insulin resistance and inflammation were observed.…"

The investigation of treatment design parameters on carbon integration networks حسب Sabla Y. Alnouri (6331652)

"…Additionally, the optimal diameter of the treatment column was more responsive to changes in solvent temperature for cases with low net capture targets (below 10%), while its sensitivity decreased for higher capture targets (above 10%).…"