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161
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The effects of Ramadan fasting on clinical and biochemical markers among hemodialysis patients: A prospective cohort study
Published 2019“…Diabetes was independently associated with increased IDWG by 0.48 kg (0.25, 0.72). …”
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165
NKX6.1 transcription factor: a crucial regulator of pancreatic β cell development, identity, and proliferation
Published 2020“…<p dir="ltr">Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progressive reduction in insulin-producing β cell mass. …”
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166
Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose
Published 2021“…Endothelial-to-mesenchymal-transition (EndMT) appears to play a role in diabetes-associated fibrotic conditions. Here, we investigate whether EndMT is implicated in the diabetic retinopathy fibrotic process and evaluate the possibility that resveratrol could counteract EndMT by inhibiting high glucose (HG)-induced increases in ROS. …”
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167
DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases
Published 2018“…Multivariate logistic regression analysis showed that DUSP1 and hsCRP are independently associated with CVD in the studied population, as reflected by 2-fold and 1.5-fold increased risks with increased levels of DUSP1 and hsCRP, respectively. …”
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168
12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
Published 2013“…Treatment of REC with HETE also increased ROS generation and expression of NOX2 and pVEGF-R2 and decreased pSHP1 expression. …”
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169
Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
Published 2024“…Recent studies have also shown <i>RFX6</i> variants to be linked with type 2 diabetes. Despite RFX6’s known function in islet development, its specific role in diabetes pathogenesis remains unclear. …”
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170
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Challenges in child and adolescent health across the Arab Gulf countries—Focus on metabolic health
Published 2025“…The combination of an increasing youth population combined with rapid modernisation, increasing per capita income and the paradigm shift towards unhealthy and affluent lifestyles has created a significant burden of non‐communicable diseases (NCDs), especially obesity and diabetes. …”
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Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
Published 2023“…<p dir="ltr">Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering blood glucose levels effectively via increasing the glomerular excretion of glucose. …”
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173
Successful use of MiniMed 780G during pregnancy
Published 2023“…<h3>Background</h3><p dir="ltr">Pregnancy in the setting of type 1 diabetes (T1D) is associated with increased morbidity and mortality. …”
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174
DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression
Published 2015“…Nevertheless, DNAJB3 expression pattern in diabetic subjects and its mode of action are not yet known. …”
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A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country
Published 2022“…The trend among SGLT2is suggests greater preference for empagliflozin over dapagliflozin.…”
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177
Emerging Glycation-Based Therapeutics—Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
Published 2022“…<div><p>The abnormal accumulation of methylglyoxal (MG) leading to increased glycation of protein and DNA has emerged as an important metabolic stress, dicarbonyl stress, linked to aging, and disease. …”
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178
Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone
Published 2020“…A similar increase in DNAJB3 mRNA was also observed in HepG2 cells. …”
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179
Association of Differing Qatari Genotypes with Vitamin D Metabolites
Published 2020“…This may be of specific importance in vitamin D replacement strategies with the Q2 genotype requiring less, and the other genotypes requiring more to increase 1,25(OH)2D. Whilst overall the group was vitamin D deficient, total 25(OH)D was higher in diabetes, but 1,25(OH)2D, 24,25(OH)2D, and 3epi-25(OH)D were lower in diabetes that did not affect the relationship to genotype.…”
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Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal
Published 2019“…<p dir="ltr">Metabolic dysfunction of endothelial cells in hyperglycemia contributes to the development of vascular complications of diabetes where increased reactive glycating agent, methylglyoxal (MG), is involved. …”