Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibr... by Faour, Wissam

“…The eicosanoid didn't potentiate IL-1β-induced COX-2 expression nor did it activate COX-2 gene expression in quiescent cells. …”
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The development of psychological and associated mental health disorders after road traffic crashes and other injuries by Anthony Joseph (3383735)

“…<p dir="ltr">Injury contributes approximately 12% of the world’s burden of injury and there is increasing evidence that injury results in the new onset of a range of psychiatric disorders. …”

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes by Shadi Nejat (19457212)

“…However, we did not observe the same changes in the other KO lines. …”

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing by Mohamad Saad (214545)

“…However, the 9p21 locus did not replicate. Six suggestive (<i>P</i><10−5) new loci/genes with plausible biological function were identified (eg, <i>CORO7</i>, <i>RBM47</i>, <i>PDE4D</i>). …”

Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled trials by Huzaifa Ahmad Cheema (16328980)

“…TXA was associated with a beneficial effect in our secondary outcomes including decline in hemoglobin levels and the need for additional uterotonic agents. TXA increased the risk of non-thromboembolic adverse events but, based on limited data, did not increase the incidence of thromboembolic events. …”

The Effects of the COVID-19 Pandemic on Undergraduate Students’ Stress and Anxiety in a University in the UAE by Alfalasi, Khulood

“…This study argues and claims that the COVID-19 pandemic did not have a direct impact as an epidemic on student academic stress. …”
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Hyperaminoacidaemia at postprandial levels does not modulate glucose metabolism in type 2 diabetes mellitus by Bassil, M.

“…Whereas phosphorylation of AKTSer473, AKTThr308 mTORSer2448 and rpS6Ser235/236 increased (p < 0.05) with elevated amino acids, that of IRS-1Ser636/639 and IRS-1Ser1101 did not change. …”
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Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors by Gaur, Puja

“…Although many primary cell lines failed to grow, CNDT96 ALDH+ cells formed spheres in anchorage-independent conditions, whereas ALDH- cells did not. CNDT2.5 ALDH+ cells formed spheres, whereas ALDH- cells did not. …”
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Do high energy-efficient buildings increase overheating risk in cold climates? Causes and mitigation measures required under recent and future climates by Mutasim Baba, Fuad

“…While without adequate ventilation, the overheating risk in high-energy-efficient buildings can be higher than old buildings, where decreasing wall and window U-values and infiltration rate has a greater contribution to the increase of indoor temperature, while decreasing window SHGC has a lower contribution to the decrease in indoor temperature compared to the case with adequate ventilation. …”
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Risk factors for stoma outlet obstruction: systematic review and meta-analysis by Ali Toffaha (18111886)

“…Although age was assessed as a potential risk factor, it did not show a statistically significant association with SOO (OR 1.69, 95% CI 0.44–6.54).…”

Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials by Derek K., Chu

“…With moderate- to high-certainty evidence, group 5 TCS improved 6—among the best for 3; group 4 TCS and delgocitinib improved 4—among the best for 2; ruxolitinib improved 4—among the best for 1; group 1 TCS improved 3—among the best for 2. These interventions did not increase harm. Crisaborole and difamilast were intermediately effective, but with uncertain harm. …”
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Postprandial hyperaminoacidaemia overcomes insulin resistance of protein anabolism in men with type 2 diabetes by Bassil, M.

“…Results In Hyper-2 vs Hyper-1 clamps, leucine flux (2.99 ± 0.16 vs 2.62 ± 0.06 μmol kg [fat-free mass (FFM)]−1 min−1), rates of synthesis (2.31 ± 0.15 vs 1.98 ± 0.06) and breakdown (2.38 ± 0.16 vs 2.00 ± 0.07) were higher (p < 0.05), but leucine oxidation and net balance did not differ. In Hyper-3 vs Hyper-2 clamps, leucine flux and synthesis and oxidation rates increased markedly as did net balance (0.84 ± 0.09 vs −0.07 ± 0.04 μmol [kg FFM]−1 min−1, p < 0.0001). …”
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A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells by Abou-Ghazal, Mohamed K.

“…The p-STAT3 inhibitor WP1066 enhanced CD3+ (which contained Tregs) but not CD8+ T cell cytotoxicity against human A375 melanoma cells, indicating that this p-STAT3 blockade agent did not directly activate CD8+ T cells. Furthermore, the p-STAT3 inhibitor did not enhance the cytotoxicity of CD3+CD25− T cells (from which Tregs were excluded), indicating that the enhanced cytotoxicity of WP1066 is secondary to its inhibition of Tregs. …”
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Pharmacist-driven antimicrobial stewardship interventions in patients with COVID-19: a scoping review by Z. G. Nasr (17785694)

“…Studies that reported antimicrobial stewardship (AMS) interventions performed by pharmacists in COVID-19 patients were included. Articles that did not report outcomes or did not mention pharmacists in the intervention were excluded. …”

Outcomes of drain versus no drain in total knee arthroplasty: a retrospective cohort study by Anas Albasha (17765964)

“…The aim of this study is to compare the outcomes of patients who received suction drains versus those who did not, focusing on blood loss, blood transfusion need, and length of hospital stay.…”

Behavior of FRP-RC Columns Using BFRP Ties under Concentric Loading by Obeidat, Khaled

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Gaining or Losing Team Ball Possession: The Dynamics of Momentum Perception and Strategic Choice in Football Coaches by Walid Briki (688845)

“…Nonetheless, both variables displayed asymmetrical effects, in the sense that: (1) the strength of positive PM appeared to be easier to decrease than to increase; and (2) the greater the positive PM (or the negative PM), the lesser (or the greater) the coaches’ tendency to make a change in the organization of their teams. …”

Effect of consanguinity on birth weight for gestational age in a developing country by Wakim, Gerard

“…No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. …”
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Validation of a modified obstetric comorbidity index for prediction of postpartum adverse events including fetal morbidity - a retrospective cohort study from Qatar by Fouad Chaalan (22457797)

“…Around 5% of the babies had fetal distress in labour and low UA pH. For every 1 unit increase in OBCMI score, the odds of SMM increased by 44% (OR 1.44 95% CI 1.30–1.59; <i>p</i> < 0.001; AUC 0.66), and CFM increased by 28% (OR 1.28 95% CI 1.15–1.42; <i>p</i> < 0.001; AUC 0.61). …”

Comfort Assessment of a Fully/Semi-enclosed Courtyard: Case Study of Bahrain Low Rise Villa Housing Model by Al Awadhi, Maryam Hasan

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