Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... حسب Michael, Brauer

"…For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Characterizing the Effect of Arginine Deprivation on Autophagic Response in Breast Cancer cells حسب Haidar, Fatemah

"…In this project, we first inspected ASS-1 expression in human breast cancer patients and found that it decreases progressively with tumorigenesis and metastasis. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Intravitreal adalimumab in active noninfectious uveitis حسب Hamam, Rola N.

"…Seven out of 12 eyes had improvement of ≥2 ETDRS lines. Three out of three eyes had resolution of anterior chamber cells. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Investigating the Role of Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) in Inflammatory Bowel Disease: Expression in Clinical Samples and Insights from In Vitro Models حسب Mezher, Nawal

"…Using Caco-2 and HT-29 intestinal epithelial cell lines stimulated with Tumor Necrosis Factor-α (TNF-α) or Dextran Sodium Sulfate (DSS) as in vitro models of inflammation, we observed upregulation of ACSS2 protein expression. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling حسب Fostok, Sabreen

"…Background: The expression of connexin 43 (Cx43) is disrupted in breast cancer, and re-expression of this protein in human breast cancer cell lines leads to decreased proliferation and invasiveness, suggesting a tumor suppressive role. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Run Rules-Based EWMA Charts for Efficient Monitoring of Profile Parameters حسب Ali Yeganeh (16624998)

"…., intercept, slope and average residual between sample and reference lines) by integrating them with run rules in order to quickly detect various magnitudes of shifts in profile parameters. …"

Breast cancer cells and bone marrow mesenchymal stromal cells حسب Faour, Wissam H.

"…Co-cultures with either MG-63 cells or MSCs induced OPG and MMP-2 in both tumor cell lines. Interestingly, conditioned medium from co-cultures of MSCs and MDA-MB-231 cells significantly decreased the proliferation of activated T lymphocytes which was reversed by addition of anti-OPG antibodies to the co-cultures. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes حسب Shadi Nejat (19457212)

"…Three DNAJB3 knockout (KO) lines were generated (KO 30, 44 and 47), using CRISPR-Cas9. …"

Intravitreal bevacizumab (Avastin) treatment of retinal angiomatous proliferation حسب Ghazi, Nicola G.

"…Results: Twelve eyes (92.3%) had stable or improved BCVA, and 8 eyes (61.5%) had at least 2 lines of vision improvement. The average BCVA improved from 20/203 at baseline to 20/113 at 12 weeks (P = 0.001). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

PSA-activated proaerolysin as a prostate specific cancer therapy حسب Abi-Habib, Ralph

"…Activity toward proaerolysin was decreased 10-100 fold for each of the proteases tested except PSA, which showed a 4-fold increase in activity against the modified protein. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The mechanism of action of kefir and its effect on the motility of breast and colorectal cancer cells. (c2013) حسب Khoury, Nathalie El

"…In this study, we aim to determine a possible mechanism of action of kefir and to study its effect on the motility of colorectal and breast cancer cell lines. Results from the reverse-transcription PCR experiment have shown that kefir decreases the expression of TGF-α and TGF-β1 in HT-29 cells in a dose dependent manner. …"
احصل على النص الكامل
احصل على النص الكامل

ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder حسب Sara Cuvertino (18892069)

"…<i>ACTB</i> mRNA expression levels in lymphoblastic lines and fibroblasts derived from affected individuals were decreased in comparison to those in control cells. …"

An Investigation into the factors influencing Arabic speaking students’ proficiency in the Arabic language in Dubai British School حسب AL AHMAD, ALAAEDDIN MEHY

"…However, those Arabic-speaking students attending non-Arabic schools become less proficient in the Arabic language and continually fall behind their peers in Arabic schools. This is despite the fact that both groups of students are native Arabic speakers, and that both groups of students attend Arabic classes that use the same curriculum and textbooks. …"
احصل على النص الكامل

Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death حسب Tohme, Sara

"…Scavenging ROS using NAC significantly decreases cell death but has minimal effect on autophagy activation, suggesting that the accumulation of ROS is downstream of autophagy activation but upstream of cell death. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion حسب Khoury, Nathalie

"…Kefir's anti‑cancer potential was tested on CRC cell lines, Caco‑2 and HT‑29, through cytotoxicity, proliferation, and apoptotic assays. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin study حسب Brit Mollenhauer (482499)

"…The use of common reference CSF samples decreased the differences in α‐synuclein concentration between detection methods and technologies. …"

Composite hydrogels from carrageenan-cl-carboxymethyl chitosan–PVA incorporated ZiF-8 as dressing material for wound healing applications حسب Tooba Yasin (19131382)

"…It was found that increasing ZiF-8 decreases the swelling in different media and increases degradation in PBS media. …"