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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic...
منشور في 2021"…Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. …"
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An investigation into links between UAE STI Policy and the Federal Universities STEM Majors’ Enrolments, Graduates and Research Development: an evidence-based exploration of the im...
منشور في 2020"…Zayed University-Dubai had greater STEM majors’ enrolments compared to Zayed University-Abu Dhabi. …"
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The Photocatalytic Degradation of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Presence of Silver–Titanium Based Catalysts
منشور في 2020"…Byproducts of degradation were evaluated using Gas chromatography/mass spectrometry (GC–MS), resulting in 2,3,7-trichlorodibenzo-p-dioxin, a lower chlorinated congener and less toxic, as the main degradation product. Enzyme Linked Immunosorbent Assay (ELISA) was used to evaluate the relative toxicity of the degradation byproducts were a decrease in optical density indicated that some products of degradation could be potentially more toxic than the parent TCDD. …"
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A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor
منشور في 2022"…<p dir="ltr">The main protease, M<sup>pro</sup>, is critical for SARS-CoV-2 replication and an appealing target for designing anti-SARS-CoV-2 agents. …"
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Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31
منشور في 2020"…RT-qPCR assays revealed that LRRK2 transcripts were dramatically reduced in our microdeletion patient DGDP289A compared to his healthy grandfather with no deletion. The decreased expression of LRRK2 may affect protein–protein interactions between LRRK2 and its binding partners, of which eight have previously been linked to intellectual disability. …"
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Cost-effectiveness of novel treatment of hepatitis C virus in Lebanese patients
منشور في 2018"…Sensitivity analysis showed that a 25% decrease in the cost of dual drug option resulted in a decrease of incremental cost to 16,982 euro per QALY gained at first year of treatment with DAAs upon early HCV diagnosis. …"
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Simulation Study of Thermal Effects of Vegetation Covered Sand dune mounds within the Landscape around Urban Structures in the UAE
منشور في 2012"…This research topic aims to study the effects of vegetation in the shape of sand dune formations to help reduce effects of urban heat island in Dubai, as well as, link back to the cities original typography. Computer simulation was chosen as the major methodology in this research and ENVI-met software was applied as the main simulation tool. …"
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DLC2/StarD13 plays a role of a tumor suppressor in astrocytoma
منشور في 2012"…This was found to be mainly through cell cycle arrest independently of apoptosis. …"
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Predictors of Disordered Eating in Young Males
منشور في 2017"…Therefore, the latter pathway was removed from the model. The link between media pressure, strategies to decrease body weight and emotional eating was partially mediated by depressive symptomatology. …"
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Investigating the moderating role of Export PromotionProgrammes using evidence from North-Africa
منشور في 2017"…The study considers the influence of procedural, informational, environmental and functional barriers on export propensity, to uncover the moderating role of trade missions, trade shows and export seminars and workshops on such relationships. To examine these links, five main hypotheses are proposed and tested through a non-linear partial least squares structural equation modelling on a sample of 128 Algerian SMEs. …"
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Effects of natural organic matter on aggregation kinetics of boron nanoparticles in monovalent and divalent electrolytes
منشور في 2010"…However, the attachment efficiency kept increasing in the presence of CaCl2 and alginate with the increase in the electrolyte concentration and was greater than unity at >4 mM CaCl2. …"
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Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults
منشور في 2022"…Objective: According to the World Health Organization (WHO), depression is the main cause of disability worldwide and high risk was noticed in Saudi Arabia. …"
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Reliability of high strain ionomeric polymer transducers fabricated using the direct assembly process
منشور في 2007"…This is enhanced in this study by using a PUU linking polymer that has good adhesion properties to gold. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Methods: An alert was built into the pharmacy computer system, which warned pharmacists about a potassium level greater than 5.1 mEq/L when processing an order that could increase potassium. …"
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Surgical Strategies for Synchronous Colorectal Liver Metastases in 156 Consecutive Patients
منشور في 2015"…Surgical resection of all tumor sites is the only treatment that enables prolonged survival, but the synchronous presentation of CLM has been associated with poor outcomes.1 Preoperative chemotherapy is widely used in these patients to provide early treatment of metastatic disease, to improve patient selection for surgical resection,2 and 3 and to decrease the recurrence rate after surgery.4 The traditional surgical strategy for patients with resectable synchronous CLM includes resection of the primary tumor followed by chemotherapy and then liver resection. …"
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article