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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
Published 2019“…PD-L1 promoter was significantly hypomethylated in MCF-7 tumorspheres, but not from BT-549 tumorspheres, compared with their cell line counterparts. The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”
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102
Cost-effectiveness of novel treatment of hepatitis C virus in Lebanese patients
Published 2018“…Sensitivity analysis showed that a 25% decrease in the cost of dual drug option resulted in a decrease of incremental cost to 16,982 euro per QALY gained at first year of treatment with DAAs upon early HCV diagnosis. …”
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103
Exploring urban growth–climate change–flood risk nexus in fast growing cities
Published 2022“…To this end, this study overviews the main stages of Doha’s urban growth and influencing climatic factors during this period. …”
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104
The Photocatalytic Degradation of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Presence of Silver–Titanium Based Catalysts
Published 2020“…Byproducts of degradation were evaluated using Gas chromatography/mass spectrometry (GC–MS), resulting in 2,3,7-trichlorodibenzo-p-dioxin, a lower chlorinated congener and less toxic, as the main degradation product. Enzyme Linked Immunosorbent Assay (ELISA) was used to evaluate the relative toxicity of the degradation byproducts were a decrease in optical density indicated that some products of degradation could be potentially more toxic than the parent TCDD. …”
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105
Effect of StarD13 on colorectal cancer proliferation, motility and invasion
Published 2014“…Colon cancer is a cancer of the epithelial cells lining the colon. It is mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. …”
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106
What drives cryptocurrency pump and dump schemes: Coin versus market factors?
Published 2024“…These include lower market capitalization, lower trading volume, greater social media popularity, increased developer activity, and fewer exchanges trading them. …”
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107
Effect of dietary protein level on gentamicininduced nephrotoxicity in rats and on the circadian rhythms of food ingestion
Published 2006“…In a second study, rats were fed the same diets, however, the treatment given was a sham injection. …”
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108
Thermodynamic analysis of a novel integrated geothermal based power generation-quadruple effect absorption cooling-hydrogen liquefaction system
Published 2012“…Moreover, increasing the temperature of geothermal source degrades the performance of the quadruple effect absorption system (QEAS), but at the same time it affects the liquefaction production rate of hydrogen gas in a positive way. …”
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109
An empirical evaluation of the technology cycle time indicator as ameasure of the pace of technological progress in superconductortechnology
Published 1999“…This study found the trend in TCT changed abruptly from gradually increasing (slowing in cycle time) to steadily decreasing (speeding up in cycle time) following the discovery of high-temperature superconductors. …”
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110
Intravitreal bevacizumab (Avastin) treatment of retinal angiomatous proliferation
Published 2008“…Six eyes underwent fluorescein angiography at the 12-week follow-up visit; 3 (50%) of these eyes had decreased leakage compared with baseline. Both stabilization of vision and improved CMT were maintained for at least 8 weeks after a single injection in almost all eyes. …”
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111
Distribution and predictors of emergency department charges
Published 2016“…Results: Findings revealed that the professional fee (40.9 %) followed by facility fee (26.1 %) accounted for the majority of the ED charges. While greater than 80 % of visit charges went to physician and facility fee for low acuity cases, these contributed to only 52 and 54 % of the high acuity presentations where ancillary services and solutions’ contribution to the total charges increased. …”
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112
Do interleukin-6 and macrophage-migration inhibitory factor play a role during sex-associated susceptibility in murine cysticercosis?
Published 2002“…However, in wild-type strains, females have twice as many parasites as males. At the same time, there is a decrease of 80% in testosterone and dihydrotestosterone serum levels, and a 100-fold increase in the levels of estradiol in infected male mice. …”
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113
Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
Published 2021“…Observation procedures: SD-OCT and ImageJ. Main outcome measure: mean reflectivity of retinal and choroid layers. …”
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114
Exploring Sustainable Strategies for Shelter Design at Refugee Camps: The Case of Domiz 1 Refugee Camp in Iraq
Published 2017“…As a result, the proposed strategy provides an opportunity for personalization and deepens the refugees’ sense of belonging and dignity. Furthermore, a 42% decrease in cooling loads, and 31% decrease in heating loads was achieved by using the proposed wall panel, the sunspace during winter, and the roof canopy during winter, in comparison to the baseline case, the UNHCR tent.…”
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Anti-angiogenic effect of nano-formulated water soluble kaempferol and combretastatin in an in vivo chick chorioallantoic membrane model and HUVEC cells
Published 2023“…Morphometric analysis of CAM showed that treatment with nano-formulated water-soluble kaempferol and combretastatin caused a substantial decrease in density, vessel network, branch points, and nets of CAM blood vessels. …”
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116
Priority-Driven Area Optimization in High-Level Synthesis
Published 2011“…The aim of the priority function is to guide the simulated annealing process into finding the best solution while at the same time incurring the least possible execution time. …”
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117
The Effect of the Variation of the Modulus of Subgrade Reaction on the Design of Large Shallow Foundations
Published 2022“…The effect of the variability of ks along the same raft on steel reinforcements is investigated while taking into consideration other aspects such as mat rigidity and soil/rock modulus values. …”
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Communication Network for Ultrasonic Acoustic Water Leakage Detectors
Published 2020“…The authors also studied the potential of using the recent Terahertz imaging technology for the same application. Acoustic detectors were found the most suitable technology for the atmosphere in UAE, where the levels of humidity and, consequently, soil moisture are high, because both of GPRs and IR cameras operational capability to detect leaks tend to decrease sharply as soil moisture increases. …”
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120
Combined bronchodilators (tiotropium plus olodaterol) for patients with chronic obstructive pulmonary disease
Published 2015“…The combination of olodaterol and tiotropium provided additional improvements in lung function greater than monotherapy with each drug alone. Several well-designed randomized trials confirmed that the synergistic effect of both drugs in combination was able to improve lung function and health-related quality of life without a significant increase in adverse effects. …”
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