Genomic Landscape And Structural Impact Of Biotinidase (BTD) Variants In A Middle Eastern Population by BalaSubramani Gattu Linga (19325617)

“…MD simulations indicated that H323R, D444H, and P497S exhibited greater structural flexibility (increased RMSD/RMSF and PCA trace values), whereas R209C and D444H demonstrated reduced compactness (higher radius of gyration). …”

Visible Light Photocatalytic Activity of Ag/WO₃ Nanoparticles and its Antibacterial Activity Under Ambient Light and in The Dark by Maha Matalkeh (17148358)

“…HRTEM, XPS analysis shows that the photocatalyst has a large sheet-like morphology with well-dispersed small metallic Ag particles (<3 nm) on the WO₃ nanoparticle's surface, with most particles near the edges. …”

Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy by Olfa Khalifa (10914452)

“…<div><p>Non-alcoholic fatty liver disease (NAFLD) is a common liver lesion that is untreatable with medications. Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently emerged as a potential NAFLD pharmacotherapy. …”

An efficient failure-resilient mutual exclusion algorithm for distributed systems leveraging a novel zero-message overlay structure by Mouna Rabhi (17086969)

“…<p>In this paper, we provide a novel failure-resilient token-based mutual exclusion (ME) algorithm for distributed systems. Like a few other solutions in the literature, the proposed solution leverages a logical tree as its underlying topology. …”

Evaluation of high-temperature reverse osmosis for recycling boiler blowdown in industrial applications by Joel Minier-Matar (17052378)

“…The membrane rejection decreased from 97 % at 35°C to 92 % at 60°C; due to the increase in the diffusivities of ions at higher temperatures; however, the permeate quality met the boilers feedwater specifications. …”

Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments by Gunjan Dagar (9339276)

“…CAR-T therapy has achieved FDA approval for treating blood cancers like B-cell acute lymphoblastic leukemia, large B-cell lymphoma, and multiple myeloma by targeting CD-19 and B-cell maturation antigens. …”

Zirconium Silicate/IL/Mxene-based composite membranes for high-temperature fuel cell applications by Edwin, Reeves Nayagam

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Pavement Crack Assessment Using Satellite Remote Sensing and Deep Learning Model by Al Adab, Maryam

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Two-surgeon technique of parenchymal transection contributes to reduced transfusion rate in patients undergoing major hepatectomy by Palavecino, Martin

“…Despite these improvements, blood transfusion is still reported in more than one third of patients who undergo liver resection.4, 5, 6 and 7 These high rates of blood transfusion are likely associated with patient and tumor factors. …”
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Mixed siliciclastic-carbonate-evaporite sedimentation in an arid eolian landscape: The Khor Al Adaid tide-dominated coastal embayment, Qatar by John M., Rivers

“…The overall landward increase in salinity is accompanied by a decrease in the diversity of benthic fauna and their skeletal remains. …”
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Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function by Muge Sarper (3855454)

“…Conversely, knock-down of MMP-8 in N-1089 reduced adhesion and increased migration. Expression of MMP-8 WT in β6-1089 led to greater localisation of α6β4 to HD and reduced retraction fibre formation, this being reversed by MMP-8 knock-down in N-1089. …”

Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021 by Stein Emil, Vollset

“…We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050. …”
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Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 by Hmwe Hmwe Kyu (8674014)

“…Age-standardised incidence and mortality rates were 1·17 times (95% UI 1·16–1·18) and 1·31 times (95% UI 1·23–1·41) greater in males than in females in 2019. Between 1990 and 2019, LRI incidence and mortality rates declined at different rates across age groups and an increase in LRI episodes and deaths was estimated among all adult age groups, with males aged 70 years and older having the highest increase in LRI episodes (126·0% [95% UI 121·4–131·1]) and deaths (100·0% [83·4–115·9]). …”

Clinical characteristics and treatment outcomes of coats disease in a Saudi Arabian population by Al-Qahtani, Abdullah

“…Results: The most common presenting complaint was decreased visual acuity followed by strabismus and then leukocoria. …”
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From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease by Ahmad Raza (18205961)

“…This review focuses on the potential mechanisms associated with these two diseases, like insulin resistance, inflammation, oxidative damage, mitochondrial injury, and cell death. …”

Association Between Three-Months Vitamin D Supplementation and Depressive Symptomatology incidence among Saudi Arabian Adults by Khaddaj, Rashel

“…After three-months supplementation of 50,000IU, vitamin D levels increased to 51.41 ±11.27ng/ml in the supplemented group and to24.95 ±6.45ng/ml in placebo group (p=0.00). PHQ-9 scores decreased from 12.53 ±5.33 to 4.92 ±2.44 in vitamin D group (p <0.001), and from 12.46 ±4.66 to 8.96±3.75in the control group (p<0.001), indicating enhancement in depressive symptomatology. …”
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The effect of microbiome therapy on COVID-19-induced gut dysbiosis: A narrative and systematic review by Mahmoud Yousef (9900837)

“…Further, bidirectional communication between the gastrointestinal tract and vital organs like the lung, heart, brain, and liver can exacerbate the disease severity and cause further inflammation and dysbiosis. …”

Novel proteins implicated in lipid metabolism disorders by Nature Research (16552612)

“…After feeding, its expression is decreased, promoting the uptake of dietary lipids in fat tissue. …”

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis by Meritxell Espino‐Guarch (22565774)

“…Decreased proteolysis in LAT2KO animals was associated with increased mTORC1 translocation to the lysosome (mTORC1‐Lamp1 colocalization in fasted LAT2KO muscles was 1.23‐fold, <i>p</i> < 0.0001). …”

Biomarkers show promise for treatment of heart valve disease by Nature Research (16552612)

“…They are also comparing the levels of valve tissue markers with microRNAs and toll-like receptors, proteins involved in the immune system, in experimentally produced aortic stenosis in rabbits.…”