A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate حسب Geethakumari, Anupriya M

"…Gaussian accelerated molecular dynamics (GaMD) simulations of the predicted alpha-helical synthetic Mpro cleavage sequences revealed a dynamic nature of the cleavage sequences, which is critical for their efficient cleavage, and a relatively short end-to-end distances, which is required for high BRET. Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 حسب Joan B Soriano (6458528)

"…Deaths due to chronic respiratory diseases numbered 3 914 196 (95% UI 3 790 578–4 044 819) in 2017, an increase of 18·0% since 1990, while total DALYs increased by 13·3%. …"

Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021 حسب Sirota, Sarah Brooke

"…The global all-age incidence rate of URIs decreased by 10·1% (–12·0 to –8·1) from 1990 to 2019. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

State of Global Financial Crime In-­depth Analysis on GCC Countries حسب Odeh, Layan Mazen

احصل على النص الكامل

Effects of the addition of a high energy density fuel, adamantane to diesel on its cetane number, sooting propensity, and soot nanostructural properties حسب Al Zaabi, Alanood

"…Soot particles, released during diesel combustion, adversely affect human health and the environment. Some studies suggest blending diesel with oxygenated fuels to reduce soot emissions, though it also reduces fuel economy and may produce new pollutants such as aldehydes. …"
احصل على النص الكامل

An Evaluation of Short-Term Effects of Different Soil Management Systems on Soil Physical, Structural and Hydraulic Properties and an Estimation and Optimization of Water Infiltrat... حسب Merheb, Caroline

"…However, the addition of organic matter enhanced such qualities with some limitations. The advantage of tilled layers over undisturbed soils is the better conductivity of water due to larger and better sorted pores. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis حسب Meritxell Espino‐Guarch (22565774)

"…Decreased proteolysis in LAT2KO animals was associated with increased mTORC1 translocation to the lysosome (mTORC1‐Lamp1 colocalization in fasted LAT2KO muscles was 1.23‐fold, <i>p</i> < 0.0001). …"

Energy saving potential analysis applying factory scale energy audit – A case study of food production حسب Derar, Al Momani

"…The results of a preliminary energy audit carried out at a sizable industrial facility in Jordan that creates some of the most well-known foods in the Middle East are presented in this study. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains حسب Riachi, Naji J.

"…These results are consistent with the hypothesis that the rats' resistance to MPTP neurotoxicity is to some extent a property of their unique brain endothelium which has high MAO activity.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Oxandrolone Treatment in Adults with Severe Thermal Injury حسب Btaiche, Imad F.

"…However, most data on oxandrolone use in adult patients with severe thermal injury are derived from single-center studies, many of which enrolled a relatively small number of subjects and some of which had a poor design. Multicenter, prospective, randomized studies are needed to better define the optimal oxandrolone dosage and to confirm the efficacy and safety of this drug in adult patients with severe thermal injury.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling حسب Khalifeh, Mohamad Rabieh

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Hypertension in Childhood Nephrotic Syndrome حسب Ibrahim F. Shatat (14150601)

"…Others are associated with chronic and more sustained HTN such as renal fibrosis, decreased GFR, and progression of chronic kidney disease. …"

Epibenthic communities from offshore platforms in the Arabian Gulf are structured by platform age and depth حسب Felipe Torquato (14158845)

"…The lowest number of functional groups occurred in the early ages (2–3 years old), and some groups either increased or decreased their frequency and abundance along the years. …"

Cost-benefit analysis for the installation of cogeneration CSP technology in Cyprus حسب Poullikkas, Andreas

"…The results indicate that the electricity unit cost or benefit for both cases of electricity purchasing tariff are decreased or increased with the increase of the capacity factor and the capacity size of the plant. …"
احصل على النص الكامل

Developing a Stochastic Model to Predict Cost Overrun due to the Causes of Projects Delay in Oil Fields Construction Industry حسب ALKHOORI, KHALID ABDUL MAJEED

"…Finally, the author recommended some areas of the current study that can be developed such as mapping the causes of projects delay to other impacts, such as time overrun success criteria and to increase the number of projects delay in the regression model.…"
احصل على النص الكامل

Studying coral reef patterns in UAE waters using panel data analysis and multinomial logit and probit models حسب Ben Romdhane, Haifa

"…Furthermore, results demonstrated that the probability of severe damage increases with decreasing water oxygenation and with increasing temperature, light, salinity, acidity and nutrient levels. …"
احصل على النص الكامل

Transfusion of Plasma from Young Exercise mice ameliorates Aging-associated Cognitive Impairments on Learning and Memory through activation of Autophagy حسب Khoury, Reine

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The anti-cancer activity of 2 himachalene-6-OL extracted from daucus carota SSP. carota. (c2014) حسب Najm, Paul I.

احصل على النص الكامل
احصل على النص الكامل

Antecedents and consequences on employee turnover intention in the hospitality industry in Lebanon حسب Baajour, Maya

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of structural remodeling (retraction and recoil) of the pipeline embolization device on aneurysm occlusion rate حسب Jou, L.-D.

"…RESULTS: Structural changes of the device have been observed, and it was found that the Pipeline Embolization Device influences the vessel curvature in some cases. On average, it increases its diameter by 0.23 mm and decreases its length by 2.88 mm within 6 months of initial deployment. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل